Unveiling Epigenetic Molecular Mechanisms in Bone Fracture Risk: Insights From 731 Immune Cells, 1400 Metabolites, and Critical Genetic Pathways [0.03%]
揭开骨折风险的表观遗传分子机制：来自731种免疫细胞、1400种代谢物和关键遗传途径的新见解
Xiaomin Wan,Wuchao Lu,Jizhao Xue et al.
Xiaomin Wan et al.
Background: The aging population and advancements in medical science have heightened the focus on fractures, which affect over 150 million individuals annually, with substantial health and economic consequences. ...
Genetic Correlations and Causal Relationships Among Allergic Diseases: A Comprehensive Mendelian Randomization Study With Multiomic Mediation Analysis [0.03%]
过敏性疾病之间的遗传相关性和因果关系：全面的孟德尔随机化研究及其多组学中介分析
Ping-An Zhang,Jie-Lin Wang,Shi-Yan Fu et al.
Ping-An Zhang et al.
Background: Allergic diseases, including allergic asthma (AA), allergic rhinitis (AR), atopic dermatitis (AD), and allergic conjunctivitis (AC), often coexist. However, the specific inflammatory mediators driving their sh...
Allicin Attenuates Sepsis-Induced Acute Kidney Injury by Inhibiting Pyroptosis Through Negative Regulation of the PI3K/AKT Pathway [0.03%]
大蒜素通过抑制PI3K / AKT途径的阳性调节来抑制败血症引起的急性肾脏损伤中的细胞焦亡作用 attenuates sepsis-induced acute kidney injury by inhibiting pyroptosis through negative regulation of the PI3K/AKT pathway
Yanlei Zheng,Shi Li,Li Zhu et al.
Yanlei Zheng et al.
Pyroptosis is a critical mechanism leading to sepsis-induced acute kidney injury (S-AKI). Allicin, an organosulfur compound extracted from garlic bulbs, protects against S-AKI through its anti-pyroptotic role, but the underlying pathophysio...
Integrative Single-Cell and Spatial Transcriptomics Reveals the Crosstalk of CTHRC1+ CAF and MMP7+ Epithelial Axis as a Potential Therapeutic Target and Predicts Poor Clinical Outcomes in Colorectal Cancer [0.03%]
整合单细胞和空间转录组学揭示CTHRC1+CAF和MMP7+上皮轴的相互作用是结直肠癌潜在治疗靶点并预示不良临床结局
Yang Yang,Song Huang,Hanyu Zhou et al.
Yang Yang et al.
Background: Colorectal cancer (CRC) progression is heavily influenced by the tumor microenvironment (TME), where cancer-associated fibroblasts (CAFs) are key players. However, the heterogeneity, plasticity, and functional...
Pan-Immune-Inflammation Value: Related to Perforation Diameter and Pulmonary Artery Pressure in Ventricular Septal Rupture Patients [0.03%]
泛免疫炎症评分与室间隔穿孔直径及肺动脉压的关系
Xinlong Di,Zebin Lin,Qingwang Hou et al.
Xinlong Di et al.
Objective: This study investigated the relationship between the pan-immune-inflammation value (PIV) and the perforation diameter in patients with ventricular septal rupture (VSR), as well as the changes in pulmonary arter...
EZH2-Mediated Epigenetic Modifications Induce Pyroptosis in Dental Pulp Endothelial Cells via Activation of NLRP6 Inflammasome During Pulpitis Development [0.03%]
组蛋白甲基化酶EZH2通过激活NLRP6炎性小体诱导牙髓内皮细胞pyroptosis参与牙髓炎发生发展
Weilin Zhou,Weili Huang,Hongjing You et al.
Weilin Zhou et al.
Objectives: Recent studies suggest that alleviating pyroptosis may be an effective strategy for treating inflammation. This research explores the changes in cellular composition and pyroptotic pathways in dental pulp tiss...
The IRE1α Pathway Links Endoplasmic Reticulum Stress to Atherosclerosis-Related Inflammation and Lipid Accumulation [0.03%]
IRE1α通路连接内质网应激与动脉粥样硬化相关炎症和脂质蓄积
Mariam Bagheri Ekta,Natalia Elizova,Stanislav Antonov et al.
Mariam Bagheri Ekta et al.
Endoplasmic reticulum stress (ER stress) is closely related to the pathogenesis of atherosclerosis through various mechanisms, including inflammatory responses and foam cell formation. However, the mechanisms by which ER stress contributes ...
Signaling Through SCFA Receptors Gpr43 and Gpr109a Drives Pro-Inflammatory M1 Macrophage Polarization in Periodontitis [0.03%]
可通过SCFA受体Gpr43和Gpr109a信号驱动牙周炎中的促炎M1巨噬细胞极化现象
Kun Liu,Ruolin Wang,Lingxue Kong et al.
Kun Liu et al.
Background: This study investigated the link between an imbalance in microbiota-derived short-chain fatty acids (SCFAs) and dysregulated host immunity in periodontitis, focusing on the metabolic reprograming of inflammato...
Meta-Analysis
Mediators of inflammation. 2026;2026(1):e3542645. DOI:10.1155/mi/3542645 2026
The Inflammatory Nexus of Bronchopulmonary Dysplasia: From Molecular Pathways to Precision Therapeutics [0.03%]
支气管肺发育不良的炎症网络：从分子途径到精准治疗
Fei Wang,Heng Zhang,Ou Jiang et al.
Fei Wang et al.
Bronchopulmonary dysplasia (BPD) is a common and serious complication among preterm infants, particularly those born at extremely low gestational ages. It is primarily characterized by impaired alveolar and vascular development. Inflammatio...
Correction to "Phosphorylation at Ser 727 Increases STAT3 Interaction with PKCε Regulating Neuron-Glia Crosstalk via IL-6-Mediated Hyperalgesia In Vivo and In Vitro" [0.03%]
关于“Ser727磷酸化通过体内和体外IL-6介导的痛觉过敏调节PKCε与STAT3相互作用”的更正通知
Published Erratum
Mediators of inflammation. 2026;2026(1):e9757469. DOI:10.1155/mi/9757469 2026