Single-Cell Transcriptomics Uncover EEF1A1-Driven Ubiquitination Dysregulation in T Cell Exhaustion and SLE Pathogenesis via STAT1-Mediated Th1/Th2 Imbalance [0.03%]
单细胞转录组揭示EIF1AK483I介导的T细胞衰竭和SLE发病机制中STAT1调节的泛素化异常及Th1/Th2失衡
Lu Xing,Tao Wu,Hongyan Xu et al.
Lu Xing et al.
Background: Systemic lupus erythematosus (SLE) is a complex autoimmune disorder marked by immune dysregulation and multiorgan involvement. This study investigates the role of the ubiquitination-related gene EEF1A1 in SLE ...
Nonlinear Association Between the C-Reactive Protein-Triglyceride-Glucose Index and Rheumatoid Arthritis Risk: The Mediating Role of Body Mass Index [0.03%]
C-反应蛋白-甘油三酯-血糖指数与类风湿性关节炎风险的非线性关联：体重指数的介导作用
Haiping Xie,Qinwen Liu,Xuefeng Xu et al.
Haiping Xie et al.
Background: Rheumatoid arthritis (RA) is a growing public health concern with rising incidence worldwide. The C-reactive protein-triglyceride-glucose index (CTI), a composite marker of inflammation and insulin resistance,...
TRIM14 Inhibition Suppresses Microglial Polarization and Pyroptosis Through the NF-κB/NLRP3 Pathway to Enhance Spinal Cord Injury Repair [0.03%]
抑制TRIM14通过NF-κB/NLRP3信号通路抑制小胶质细胞极化和焦亡以促进脊髓损伤修复
Xin Lin,Yuan Xia,Xiu Yang et al.
Xin Lin et al.
Spinal cord injury (SCI) triggers severe neuroinflammation, impeding recovery. While microglial M1 polarization and pyroptosis are key drivers, their upstream regulators are incompletely understood. This study investigated the role of the u...
Shengqing Jiangzhuo Capsule Alleviates Intestinal Inflammation in Chronic Kidney Disease by Downregulating CHAC1 to Inactivate the HIF-1 Pathway [0.03%]
圣清降浊胶囊通过下调CHAC1抑制HIF-1信号通路从而改善慢性肾脏病肠黏膜炎症
Zhibin Li,Jian Wang,Yanna Lin et al.
Zhibin Li et al.
Background: Chronic kidney disease (CKD) imposes significant global health burdens. Shengqing Jiangzhuo (SQJZ) capsule possesses potential to alleviate CKD via gut-kidney axis, with the specific role and mechanisms involv...
RETRACTION: ET-1 Promotes Differentiation of Periodontal Ligament Stem Cells Into Osteoblasts Through ETR, MAPK, and Wnt/β-Catenin Signaling Pathways Under Inflammatory Microenvironment [0.03%]
撤稿：ET-1通过ETR、MAPK和Wnt/β-catenin信号通路促进牙周炎微环境下牙周膜干细胞向成骨细胞分化
Mediators Of Inflammation
Mediators Of Inflammation
[This retracts the article DOI: 10.1155/2016/8467849.]. Copyright © 2025 Mediators of Inflammation published by John Wiley & Sons Ltd.
Comprehensive Analysis of the PANoptosis-Related Genes in Stroke Based on Single-Cell RNA-Seq and Spatial Transcriptomics [0.03%]
基于单细胞RNA测序和空间转录组学的中风相关PANoptosis基因综合分析
Wenya Bai,Huan Jiang,Guilin Zhou et al.
Wenya Bai et al.
Background: PANoptosis is implicated in immunoinflammatory diseases, but its role in cerebral ischemia-reperfusion injury (CIRI) remains unclear. Methods:...
Circ_0058051 Targeted miR-129-5P Regulates Autophagy-Related Gene ATG7 to Promote the Inflammation of Gout [0.03%]
circ_0058051通过靶向miR-129-5p调节自噬相关基因ATG7促进痛风炎症发生
Jianwei Guo,Tianyi Lei,Yi Jiang et al.
Jianwei Guo et al.
Gout is a common autoinflammatory disease that clinically manifests as recurrent joint redness, swelling, and pain, but the molecular mechanism of recurrent gouty inflammation remains unclear. Circular RNAs (circRNAs) might exert their func...
Novel Machine Learning Approaches Revolutionize Pancreatic Malignancy Prognosis: Exploring Programed Cell Death [0.03%]
新型机器学习方法通过探索程序性细胞死亡手段革新胰腺恶性肿瘤预后判断
Na Xu,Xiaye Miao,Jiali Jiang et al.
Na Xu et al.
Pancreatic ductal adenocarcinoma (PDAC) remains a highly aggressive malignancy with a poor prognosis and limited effective treatment options. Our study comprehensively explores the complex role of programed cell death (PCD) mechanisms in PD...
A Multitrait Analysis of Genome-Wide Association Study Reveals the Shared Genetic Architecture Between Inflammatory Bowel Disease and Ankylosing Spondylitis [0.03%]
多性状的全基因组关联研究分析揭示了克罗恩病和强直性脊柱炎之间的共享遗传结构
Hongyan Li,Dadong Tang,Yanling Liu et al.
Hongyan Li et al.
Background: Clinical evidence indicates that inflammatory bowel disease (IBD) and ankylosing spondylitis (AS) often co-occur, but their genetic mechanisms remain unclear. Our objective is to explore the genetic relationsh...
Influence of Fusobacterium nucleatum on Tumor Necrosis Factor Alpha Therapy in Ulcerative Colitis [0.03%]
福斯杆菌核素对溃疡性结肠炎肿瘤坏死因子α治疗的影响
Bilge Şenyüz,Nalan Gülşen Ünal,Başak Doğanavşargil Yakut et al.
Bilge Şenyüz et al.
Inflammatory bowel disease (IBD), including ulcerative colitis (UC), involves chronic gastrointestinal inflammation, with tumor necrosis factor alpha (TNF-α) playing a key role. Anti-TNF therapy is widely used, but not all UC patients resp...