The Vitamin D3 Analog Calcipotriol Attenuates Pancreatic Cancer Malignancy via Downregulating Thrombospondin 1 in Pancreatic Stellate Cells [0.03%]
维生素D3类似物Calcipotriol通过下调胰星状细胞中血小板反应蛋白-1来抑制胰腺癌恶性进展
Yang Wu,Chun Zhang,Matthias Ilmer et al.
Yang Wu et al.
Pancreatic ductal adenocarcinoma (PDAC) exhibits pronounced desmoplasia, primarily attributed to the activation of pancreatic stellate cells (PSCs) from a quiescent state (quiescent PSCs [qPSCs]) to an activated form (activated PSCs [aPSCs]...
Association Between Sleep and Cardiovascular-Kidney-Metabolic Syndrome: Mediation Analysis of Inflammatory Biomarkers [0.03%]
睡眠与心血管-肾脏-代谢综合征的关系：炎症生物标志物的中介分析
Minjie Hu,Ying Xu,Jiao Ming et al.
Minjie Hu et al.
Background and aims: Sleep disturbances are linked to individual cardiometabolic diseases, but their association with the emerging cardiovascular-kidney-metabolic (CKM) syndrome, a constellation of interrelated conditions...
Identification and Experimental Verification Reveal SLC2A3 Associated With Prognosis and Immune Infiltration in Colon Adenocarcinoma [0.03%]
鉴定与实验验证揭示SLC2A3与结肠腺癌预后和免疫浸润相关性
Zhenyuan Zhao,Kun Ju,Jiajun Lv et al.
Zhenyuan Zhao et al.
Colon adenocarcinoma (COAD) exhibits marked molecular heterogeneity that limits accurate prognostic prediction and therapeutic stratification. Parthanatos, a poly (ADP-ribose) polymerase-1 (PARP1)-dependent form of regulated cell death, has...
Yu Chen,Yaqing Guo,Zibo Zhao et al.
Yu Chen et al.
Atrophy of skeletal muscles, caused by multiple factors, including ageing, disuse, trauma and systemic diseases, is a major pathological condition that affects physical performance and systemic health by the loss of muscle function; in effe...
Rougan Tongluo Decoction Initiates Neuroprotection Against Cerebral Ischemia by Activating the Endogenous SLC6A8-Creatine-EARS2 Mitochondrial Pathway [0.03%]
当归通络汤通过激活内源性SLC6A8-磷酸肌酸-EARS2线粒体信号通路发挥缺血脑神经保护作用
Changze Ou,Zheng-Ping Bai,Guo-Heng Hu et al.
Changze Ou et al.
Objective: The traditional Chinese medicine formula Rougan Tongluo Decoction (RGTL) was widely used to treat neurological injury after cerebral ischemia, though its specific underlying mechanisms remain unknown. This stud...
The Role of the C3a-C3aR Pathway in Diseases: Latest Research Advances [0.03%]
补体C3a-C3aR通路在疾病中的作用：最新研究进展
Xiangwei Bo,Mi Wang,Yang Liu et al.
Xiangwei Bo et al.
C3a is a key active factor in the complement system, capable of participating in various physiological and pathological processes by binding to its C3a receptor (C3aR). The C3a-C3aR pathway not only plays an important role in immune regulat...
The Nonlinear Relationship Between the Aggregate Index of Systemic Inflammation and Serum Neurofilament Light Chain Levels in U.S. Adults: A Cross-Sectional Study [0.03%]
美国成年人系统性炎症综合指数与血清神经丝轻链水平之间非线性关系的横断面研究
Jun Wei,Yang Liu,Jun Zhang
Jun Wei
Background: Systemic inflammation is linked to chronic diseases. This study examines the relationship between the aggregate index of systemic inflammation (AISI) and serum neurofilament light chain (sNfL), a marker of neu...
FGFR2 is a Candidate Immune-Associated Marker of Diabetic Foot Ulcer That Promotes Keratinocyte Function by Activating the PI3K/Akt and MAPK Pathways [0.03%]
FGFR2是糖尿病足溃疡免疫相关标志物候选者，通过激活PI3K/Akt和MAPK通路促进角质形成细胞功能
Hailan Chen,Hongfei Sang,Yi Shi et al.
Hailan Chen et al.
Objective: Diabetic foot ulcer (DFU) is a serious complication of diabetes. This study aims to screen DFU-associated immune-related genes (IRGs) and investigate their potential functional mechanisms and clinical relevance...