Paeoniflorin Alleviates LPS-Induced Inflammation and Acute Myocardial Injury by Inhibiting PI3K/Akt/ERK-Mediated HIF-1α and TLR4/MyD88/NF-κB Inflammatory Signaling [0.03%]
芍药苷通过抑制PI3K/Akt/ERK介导的HIF-1α和TLR4/MyD88/NF-κB炎症信号缓解LPS诱导的炎症及急性心肌损伤
Xiaowu Guo,Zhiguang Han,Jiahuan Sun et al.
Xiaowu Guo et al.
Sepsis-induced myocardial injury (SIMI) greatly increases the mortality rate of sepsis. Although paeoniflorin (PF) has been proven to improve survival in sepsis, the detailed mechanism of PF on SIMI remains elusive. In this study, network p...
The Role of Sterile Inflammation in Thrombosis: Consequences for Cardiovascular Disease and COVID-19 [0.03%]
无菌性炎症在血栓形成中的作用及其对心血管疾病和新冠肺炎的影响
Gausal Azam Khan,Mashael Huwaikem,Kaustav Chowdhury et al.
Gausal Azam Khan et al.
Sterile inflammation (SI) is an inflammatory response triggered by the release of damage-associated molecular patterns (DAMPs) from dying cells, distinct from normal inflammation in its origin from tissue injury and necrosis rather than mic...
Impact of New Inflammation/Nutrition-Based Indicators on Prognosis in Elderly Patients With Colorectal Cancer [0.03%]
新型炎症/营养基于指标对老年结直肠癌患者预后的影响
Wenda Xu,Chen Qin,Hanyu Yang et al.
Wenda Xu et al.
Objective: This study aimed to investigate the impact of new inflammation/nutrition-based indicators-the modified cachexia index (mCXI) on the prognosis of elderly patients with colorectal cancer and develop a nomogram mo...
Association of Immune Cells, Inflammatory Cytokines, and Lung Cancer: A Mediating Mendelian Randomization Study [0.03%]
免疫细胞、炎症细胞因子与肺癌相关性研究：一种中介梅伦德尔随机化研究方法
Lang Li,Ying Zhu,Chenchong Zhao et al.
Lang Li et al.
Background: Lung cancer oncogenesis involves interactions between immune cells and inflammatory cytokines. However, their causal relationships and mediating mechanism remain unclear. ...
Clinical Use of Nomogram Based on Machine Learning for Diagnosis Prediction of Acute Respiratory Distress Syndrome in Patients With Acute Pancreatitis [0.03%]
基于机器学习的急性胰腺炎患者急性呼吸窘迫综合征诊断预测列线图的临床应用
Hongjie Hu,Yuxin Wang,Yaqin Song et al.
Hongjie Hu et al.
Background: This study focused on utilizing machine learning techniques to construct a predictive nomograph for early identification of acute pancreatitis (AP) patients at risk of developing acute respiratory distress syn...
Lutein Alleviate Acute Lung Injury Induced by Limb Ischemia-Reperfusion Through PPAR-γ/PI3K/AKT/NLRP3 Signaling [0.03%]
叶黄素通过PPAR-γ/PI3K/AKT/NLRP3信号通路缓解肢体缺血再灌注诱导的急性肺损伤
Chao Nie,Zhen Liu,Liang Zhang et al.
Chao Nie et al.
The detachment of cardiogenic emboli, the formation of arterial thrombosis, and the use of tourniquets in emergency situations of massive hemorrhage can all lead to acute limb ischemia. In order to save the limb, blood flow must be rapidly ...
Multiple Signaling Axes (TNF-α/IL1β/IL8, TLR4/MYD88/NF-κB, and TGF-β1/ROS) Associated With Coronary Collateral Circulation of Coronary Chronic Total Occlusion in Geriatric Patients [0.03%]
老年人冠脉慢性完全闭塞侧支循环的多个信号轴（TNF-α/IL1β/IL8、TLR4/MYD88/NF-κB及TGF-β1/ROS）研究
Yongjuan Zhao,Hualan Zhou,Ying Chen et al.
Yongjuan Zhao et al.
The multiple signaling axes might be concerned with the poor coronary collateral circulation (CCC). This research aimed to investigate the relationship between the poor CCC and multiple signaling axes (tumor necrosis factor-α [TNF-α]/inte...
LncRNA NEAT1 Knockdown Alleviates Macrophage Ferroptosis and Atherosclerosis by Suppressing STAT3 Activation [0.03%]
lncRNA NEAT1敲低通过抑制STAT3激活缓解巨噬细胞铁死亡和动脉粥样硬化
Di Wang,Maomao Zhang,Huiqi Xie et al.
Di Wang et al.
Background: This study aimed to investigate the role and mechanism of long noncoding RNA nuclear-enriched abundant transcript 1 (NEAT1) in macrophage ferroptosis during atherosclerosis (AS). ...
Chronic Inflammation in Primary Myelofibrosis: In-Depth Insights Into Pathogenesis and Promising Anti-Inflammatory Therapeutic Strategies [0.03%]
原发性骨髓纤维化慢性炎症的发病机制及有前景的抗炎治疗策略深层次见解
Meng Chen,Chengyulong Zheng,Ying Zhang et al.
Meng Chen et al.
Primary myelofibrosis (PMF) is a clonal myeloproliferative neoplasm (MPN) stemming from hematopoietic stem and progenitor cells (HSPCs), frequently associated with mutations in Janus kinase signal transducer (JAK2), calreticulin (CALR), or ...
Neutrophil-Fibroblast Crosstalk Drives Immunofibrosis in Sequelae of Pelvic Inflammatory Disease Through Neutrophil Extracellular Traps [0.03%]
中性粒细胞纤维母细胞的相互作用通过NET介导慢性盆腔炎性疾病免疫相关纤维化的发生发展关系
Chunxiao Dang,Jinxing Liu,Xiao Yu et al.
Chunxiao Dang et al.
Background: Due to the complex pathogenesis of sequelae of pelvic inflammatory disease (SPID), targeted therapeutic agents are still lacking. Here, we investigated the interactions between neutrophils and uterine fibrobla...