Efficacy and Safety of JAK Inhibitors in Lichen Planus: A Systematic Review of the Available Clinical Evidence [0.03%]
Janus激酶抑制剂治疗扁平苔藓的疗效和安全性：现有临床证据的系统评价
Wiktoria Bajek,Anna Gwóźdź,Aleksandra Kozik et al.
Wiktoria Bajek et al.
Background: Lichen planus (LP) is a chronic, immune-mediated inflammatory disorder affecting the skin, mucous membranes, hair, and nails. Conventional therapies such as corticosteroids and systemic immunosuppressants ofte...
Deletion of Circadian Rhythms Gene BMAL1 Impairs the Intestinal Epithelial Barrier and Exacerbates Intestinal Inflammation by Inducing Pyroptosis [0.03%]
节律基因BMAL1缺失通过诱导细胞焦亡损害肠上皮屏障并加重肠道炎症反应
Xin Zhou,Jie Ji,Wenhua Li et al.
Xin Zhou et al.
The circadian clock plays a crucial role in the pathogenesis of various inflammatory and autoimmune diseases, including ulcerative colitis (UC). Deletion of the core transcription factor BMAL1 exacerbated the severity of colitis. However, t...
MitoQ Ameliorates Diabetic Cardiomyopathy by Inhibiting the mtROS-TXNIP-NLRP3 Pathway [0.03%]
线粒体靶向抗氧化剂MitoQ改善糖尿病心肌病的作用及机制研究
Shaohuan Qian,Junjie Leng,Zhuoya Yao et al.
Shaohuan Qian et al.
Purpose: To determine whether mitoquinone mesylate (MitoQ) could treat diabetic cardiomyopathy (DCM) by inhibiting the mitochondrial reactive oxygen species (mtROS)/thioredoxin (TRX)-interacting protein (TXNIP)/NOD-like r...
Development of a Predictive Model for Transfusion-Related Acute Lung Injury Based on Neutrophil Extracellular Traps (NETs) [0.03%]
基于中性粒细胞胞外陷阱（NETs）的输血相关急性肺损伤预测模型的研究开发
Qiong Wang,Zhenyang Li,Junliang Shao et al.
Qiong Wang et al.
Background: Patients receiving massive transfusion after acute hemorrhage are at risk for transfusion-related acute lung injury (TRALI), a severe complication. Neutrophil extracellular traps (NETs) play a key role in acut...
Multicenter Study
Mediators of inflammation. 2026;2026(1):e7778073. DOI:10.1155/mi/7778073 2026
Phenotypic Aging and Sexual Dimorphism in C57BL/6J, SAMR1, and SAMP8 Mice: A Comparative Study [0.03%]
C57BL/6J、SAMR1和SAMP8小鼠表型衰老及性别二态性的比较研究
Luiz Adriano Damasceno Queiroz,Renata Spalutto Fontes,Mariana de Araujo Oliveira et al.
Luiz Adriano Damasceno Queiroz et al.
Aging research increasingly relies on animal models to study the multifactorial processes of senescence. This study aimed to compare the physiological and metabolic parameters of C57BL/6J mice, a reference strain for biomedical research, wi...
Comparative Study
Mediators of inflammation. 2026;2026(1):e1198691. DOI:10.1155/mi/1198691 2026
Combination of High-Fat Diet and Chronic Unpredictable Stress Synergistically Induces Osteoarthritis-Like Changes in Temporomandibular Joints in Rats [0.03%]
高脂饮食与慢性不可预测应激协同诱导大鼠下颌关节发生骨关节炎样改变
Xi Wang,Ting Hao,Ye-Hua Gan
Xi Wang
Objectives: High-fat diet (HFD) and chronic unpredictable stress (CUS) are potential risk factors for temporomandibular joint osteoarthritis (TMJOA). This study aimed to investigate whether the combination of HFD and CUS ...
Immunometabolic Dysregulation in Preeclampsia: Emerging Roles of Inflammation, Insulin Resistance, Uric Acid, and the Gut Microbiome [0.03%]
免疫代谢失调在子痫前期的作用：炎症、胰岛素抵抗、尿酸和肠道微生物群的新兴角色
Nurshad Ali
Nurshad Ali
Preeclampsia is a major cause of maternal and perinatal morbidity around the world. It is increasingly recognized as a disorder of systemic immunometabolic dysregulation rather than isolated placental dysfunction. Increasing evidence links ...
Biomarkers in QuantiFERON Supernatants May Help Distinguish Latent Tuberculosis Infection From Active Tuberculosis: Preliminary Report [0.03%]
定量福分 supernatant 中的生物标志物可帮助区分潜伏性结核感染和活动性结核：初步报告
Dagmara Borkowska-Tatar,Anna Zabost,Michał Czopowicz et al.
Dagmara Borkowska-Tatar et al.
Background: Latent tuberculosis infection (LTBI) is an important public health problem and a major source of future active tuberculosis (ATB) cases. In this preliminary study, we sought to identify host biomarkers that co...
Macrophage-Myocyte Cross Talk Induces M1 Polarization and Inflammatory Cytokine Production During Cancer Cachexia [0.03%]
巨噬细胞与肌细胞的相互作用在癌症恶病质期间诱导M1极化和炎症细胞因子产生
Se-Eun Bae,Miyong Yun,Min Ju Kang et al.
Se-Eun Bae et al.
Cancer cachexia (CC) significantly reduces survival in patients with cancer, and intramuscular inflammation plays an important role in disease progression. Macrophages, as key mediators of the innate immune response, contribute to muscle in...
Revealing the Correlation Between NLRP3 Inflammasome-Related Genes and Intervertebral Disc Degeneration Based Multiomic Analysis and Experimental Validation [0.03%]
基于多组学分析和实验验证揭示NLRP3炎症小体相关基因与椎间盘退变的相关性
Yongliang Fu,Xiangyu Wang,Guangwei Sun et al.
Yongliang Fu et al.
Purpose: NLRP3 inflammasome plays a pivotal role in the pathogenesis of intervertebral disc (IVD) degeneration (IDD). This study aimed to identify NLRP3 inflammasome-related biomarkers in IDD and analyze their functions. ...