Machine Learning and Mendelian Randomization Reveal Molecular Mechanisms and Causal Relationships of Immune-Related Biomarkers in Periodontitis [0.03%]
机器学习和梅涅尔随机化揭示牙周炎相关免疫标志物的分子机制和因果关系
Yuan Li,Bolun Zhang,Dengke Li et al.
Yuan Li et al.
This study aimed to investigate the molecular mechanisms of periodontitis and identify key immune-related biomarkers using machine learning and Mendelian randomization (MR). Differentially expressed gene (DEG) analysis was performed on peri...
Irisin Alleviates Cognitive Impairment by Inhibiting AhR/NF- κ B-NLRP3-Mediated Pyroptosis of Hippocampal Neurons in Chronic Kidney Disease [0.03%]
Irisin通过抑制AhR/NF-κB-NLRP3介导的海马神经元焦亡改善慢性肾脏病小鼠认知障碍
Jialing Zhang,Xingtong Dong,Qi Pang et al.
Jialing Zhang et al.
Introduction: Cognitive impairment is a vital complication of chronic kidney disease (CKD). The effect of irisin on CKD-induced cognitive impairment remains unclear. In the present study, we aimed to investigate the role of Irisin in mitiga...
Luteolin Alleviates the TNF- α-Induced Inflammatory Response of Human Microvascular Endothelial Cells via the Akt/MAPK/NF- κ B Pathway [0.03%]
黄酮类化合物山柰酚通过akt/mapk/nf- κ b信号通路缓解人微血管内皮细胞炎性反应
Qing-Yu Lu,Li Guo,Qi-Yun Zhang et al.
Qing-Yu Lu et al.
Endothelial dysfunction and pathological alterations are pivotal in the pathogenesis of cardiovascular disease. To date, effective interventions for these endothelial changes are lacking. Tumor necrosis factor-alpha (TNF-α) is known to sig...
Lactobacillus reuteri Alleviates Hyperoxia-Induced BPD by Activating IL-22/STAT3 Signaling Pathway in Neonatal Mice [0.03%]
罗伊氏乳杆菌通过激活IL-22/STAT3信号通路缓解新生小鼠BPD
Meiyu Zhang,Decai Li,Liujuan Sun et al.
Meiyu Zhang et al.
Bronchopulmonary dysplasia (BPD) is the most common chronic respiratory disease in preterm infants. Little is known about the regulatory effect of lung Lactobacillus and its mechanism in BPD. This study explored the effect of L. reuteri on ...
Peptide BG From Bitter Gourd (Momordica Charantia) Improves Adjuvant-Induced Arthritis by Modulating the Necroptosis/Neutrophil Extracellular Traps/Inflammation Axis and the Gut Microbiota [0.03%]
苦瓜(Momordica charantia)多肽BG通过调节坏死性凋亡/中性粒细胞胞外诱捕网/炎症轴和肠道微生物群改善弗式完全佐剂诱导的类风湿关节炎
Wenyan Han,Yanan Xu,Suyila Qimuge et al.
Wenyan Han et al.
Background: BG is a novel bioactive peptide derived from bitter gourd (Momordica charantia), known for its anti-inflammatory and immunomodulatory properties. In the present study, our objective is to investigate the functional roles and mec...
ATG16L1 Depletion-Mediated Activation of the TRAF1 Signaling in Macrophages Aggravates Liver Fibrosis [0.03%]
ATG16L1缺失通过激活巨噬细胞中的TRAF1信号加重肝纤维化
Yufeng Pan,Yi Wei,Xinyu Zhan et al.
Yufeng Pan et al.
Background: Hepatic macrophages play an indispensable role in liver pathophysiology, serving as key orchestrators of both liver injury and repair processes. ATG16L1 (autophagy-related 16 like 1) has emerged as a novel and critical autophagy...
Predictive Value of IL-6 and Lymphocyte Subsets for Death in Children With Influenza-Associated Encephalopathy A Retrospective Study [0.03%]
IL-6和淋巴细胞亚群预测儿童流感相关性脑病死亡的回顾性研究
Ruiyang Sun,Xue Zhang,Jiapu Hou et al.
Ruiyang Sun et al.
Objective: This study aims to investigate the predictive value of interleukin-6 (IL-6) and lymphocyte subsets for death in children with influenza-associated encephalopathy (IAE). Patients: This study included 76 children with IAE who were ...
Cell-Specific Regulation of Inflammatory Cytokines and Acute-Phase Proteins by the Glucocorticoid Receptor [0.03%]
糖皮质激素受体对炎性细胞因子和急性期蛋白的特异性调控作用
Rebecca Winkler,Hong Lu
Rebecca Winkler
Background: Literature and data mining found abnormal induction of chemokine (C-X-C motif) ligand 1 (CXCL1) and CXCL8 and down-regulation of CXCL2 in inflammatory liver diseases. This study was performed to understand the...
rTMS and TENS Relieve Neuropathic Pain in CCI Model Rats by Modulating Central Nervous System TRPV1 and Neuroinflammation [0.03%]
rTMS和TENS通过调节中枢神经系统TRPV1和神经炎症缓解CCI模型大鼠的神经痛
Zhangyu Xu,Quanzhen Zhong,Fei Xing et al.
Zhangyu Xu et al.
Background: Repetitive transcranial magnetic stimulation (rTMS) of the prefrontal cortex (PFC) and transcutaneous electrical nerve stimulation (TENS) have both been demonstrated as effective at alleviating neuropathic pain (NP). However, th...
The Expression Profiles and Clinical Significance of Mixed Lineage Kinases in Glioma [0.03%]
混合谱系激酶在胶质瘤中的表达及临床意义分析
Jin Huang,Yuankun Liu,Gaosong Wang et al.
Jin Huang et al.
Mixed lineage kinases (MLKs), comprising seven members: MLK1-4, dual leucine zipper kinase (DLK), leucine zipper kinase (LZK), and sterile alpha motif and leucine zipper containing kinase (ZAK), belong to the mitogen-activated protein kinas...