In Vitro, In Vivo, and In Silico Investigation of Synbiotic-Mediated Activation of PPAR- α Curtails Nonalcoholic Steatohepatitis (NASH) in Wistar Rats by Inhibiting PNPLA3/SREBP1-c Lead Inflammatory Injury of Hepatic Cells [0.03%]
共生介导的PPAR-α活化通过抑制PNPLA3/SREBP1-c减轻Wistar大鼠非酒精性脂肪性肝炎(NASH)导致的肝脏炎症损伤的体外、体内及计算机模拟研究
Dixa Sharma,Dhara Patel,Palash Mandal
Dixa Sharma
Nonalcoholic steatohepatitis (NASH) is an inflammation of the liver and a menace to human health. To treat NASH various pharmaceutical products have been used, but their prohibitive side effects limit their effectiveness. NASH, a multihit h...
Selenium Nanoparticles Decorated With Stevioside Potentially Attenuate Fructose Palmitate Induced Lipid Accumulation in HepG2 Cells [0.03%]
装饰有甜菊糖的硒纳米粒子可以潜在减轻果糖棕榈酸引起的HepG2细胞脂质积聚
Shuai Li,Hui Yang,Wenjun Zhou et al.
Shuai Li et al.
The excessive accumulation of lipid droplets within hepatocytes stands as a hallmark characteristic of metabolic-associated fatty liver disease (MAFLD). Selenium (Se) nanoparticles (NPs) have garnered considerable attention for their notabl...
Herbal Medicine Extracts Improve Motor Function by Anti-Inflammatory Activity in hSOD1G93A Animal Model [0.03%]
通过抗炎活性改善hSOD1G93A动物模型的运动功能的草药提取物研究
Eun Jin Yang,Sun Hwa Lee
Eun Jin Yang
Amyotrophic lateral sclerosis (ALS) is a multicomplex neurodegenerative disorder characterized by motor neuron death, muscle atrophy, and respiratory failure. Owing to its multicomplex mechanisms and multifactorial nature in the skeletal mu...
Inhibition of SIK1 Alleviates the Pathologies of Psoriasis by Disrupting IL-17 Signaling [0.03%]
SIK1抑制通过干扰IL-17信号缓解银屑病的病理变化
Dongxuan Huang,Huimin Sun,Lianhui Su et al.
Dongxuan Huang et al.
Psoriasis is an inflammatory skin disease mediated by multiple immune cells, including T cells, macrophages, and dendritic cells, which exhibit complex pathologies and limited clinical treatment. Here, we found that salt-inducible kinase 1 ...
Elevated Type 2 Inflammatory Factors, Th2/Th1 Balanced Status, and Exosomes as a Marker of Severity in Chronic Actinic Dermatitis [0.03%]
慢性光性皮炎中II型炎症因子升高、Th2/Th1平衡状态和外泌体作为严重程度的标志物
Tang Jun-Ting,Tu Ying,Nong Xiang et al.
Tang Jun-Ting et al.
Background: Chronic actinic dermatitis (CAD) is a skin inflammation triggered by light exposure, occurring at the exposed site and potentially causing widespread inflammation throughout the body. While we hypothesize that severe CAD could p...
NLRP3 Inflammasome Activation Is Involved in Geniposide-Induced Hepatotoxicity [0.03%]
木犀草苷致肝毒性涉及NLRP3炎性小体的激活
Yixuan Liu,Baoyue Liu,Mingzhu Shi et al.
Yixuan Liu et al.
Background: Geniposide, a prominent iridoid glycoside derived from Gardenia jasminoides J. Ellis, has garnered attention due to its association with hepatotoxicity despite its well-documented pharmacological efficacy in preclinical and clin...
Trapa natans L. Extract Attenuates Inflammation and Oxidative Damage in Cisplatin-Induced Cardiotoxicity in Rats by Promoting M2 Macrophage Polarization [0.03%]
Trapaea latifolia L. 提取物通过促进 M2 型巨噬细胞极化减轻顺铂诱导大鼠心肌毒性的炎症和氧化损伤
Vesna Matovic,Biljana Ljujic,Ivana Radojevic et al.
Vesna Matovic et al.
Background: Trapa natans L. fruits and leaf extracts have a broad range of immunomodulatory, anti-inflammatory, and antioxidant effects; however, their effects on cardiac protection have not been investigated. Objective: The study aims to t...
METTL3/miR-192-5p/SCD1 Axis Regulates Lipid Metabolism to Affect T Cell Differentiation in Asthma [0.03%]
METTL3/miR-192-5p/SCD1轴通过调节脂质代谢影响哮喘中T细胞分化
Zhengrong Chen,Dingwei Yan,Suyu Guo et al.
Zhengrong Chen et al.
Background: This study aimed to explore the mechanisms underlying T-cell differentiation in asthma. Methods and Results: Flow cytometry was performed to detect Th cells. LC-MS/MS was performed to assess lipid metabolism. HE staining was per...
Modified Gegen Qinlian Decoction Ameliorates DSS-Induced Colitis in Mice via the Modulation of NF- κ B and Nrf2/HO-1 Pathways [0.03%]
Modified Gegen Qinlian Decoction改善DSS诱导的小鼠结肠炎通过调节NF-κB和Nrf2/HO-1通路
Jinke Huang,Jiaqi Zhang,Zhihong Liu et al.
Jinke Huang et al.
Background: This study aims to reveal the potential molecular mechanisms of modified Gegen Qinlian decoction (MGQD) in relieving ulcerative colitis (UC). Methods: C57BL/6J mice were used to establish experimental colitis via dextran sodium ...
Characteristics of Pediatric Allergic Rhinitis With Different Disease Severity [0.03%]
不同疾病严重程度的儿童过敏性鼻炎临床特点分析
Yinhui Zeng,Ting Lin,Wanhua Xie et al.
Yinhui Zeng et al.
Background: Although numerous studies have focused on diagnostic biomarkers to help identify allergic rhinitis (AR), data on the characteristics of pediatric AR with different severity is limited. We aimed to compare the characteristics of ...