Heterogeneity of Neutrophils and Immunological Function in Neonatal Sepsis: Analysis of Molecular Subtypes Based on Hypoxia-Glycolysis-Lactylation [0.03%]
新生儿败血症中性粒细胞的异质性和免疫功能：基于缺氧-糖酵解-乳酸化的分子亚型分析
Huabin Wang,Ru Yang,Nan Chen et al.
Huabin Wang et al.
Objective: Hypoxia-glycolysis-lactylation (HGL) may play a crucial role in neonatal sepsis (NS). This study aims to identify HGL marker genes in NS and explore immune microenvironment among NS subtypes. Materials and Methods: The gene expre...
The Histone Deacetylase Activator ITSA-1 Improves the Prognosis of Cardiac Arrest Rats by Alleviating Systemic Inflammatory Responses Following Cardiopulmonary Resuscitation [0.03%]
组蛋白去乙酰化酶激活剂ITSA-1通过缓解心肺复苏后的全身炎症反应改善心脏骤停大鼠的预后
Chenyu Zhang,Hongyan Wei,Qiang Zhang et al.
Chenyu Zhang et al.
Objective: To investigate whether the histone deacetylase (HDAC) activator ITSA-1 can ameliorate systemic inflammation after cardiac arrest (CA), thereby enhancing cardiac function and neurological outcomes in rats. Materials and Methods: S...
Comparative Analysis of Salivary and Serum Inflammatory Mediator Profiles in Patients With Rheumatoid Arthritis and Periodontitis [0.03%]
类风湿性关节炎和牙周病患者的唾液和血清炎症介质谱的比较分析
Carina Fei,Kaja Eriksson,Guozhong Fei et al.
Carina Fei et al.
Background: Periodontitis (PD) and rheumatoid arthritis (RA) are chronic inflammatory conditions, characterized by dysregulated immune response and excessive production of inflammatory mediators. The oral disease PD is triggered by periodon...
Neutrophil-to-Lymphocyte Ratio as a Potential Predictive Marker for Epileptic Seizures: Unveiling the "V"-Shaped Link [0.03%]
中性粒细胞与淋巴细胞比值作为癫痫发作潜在预测标志物：“V”型关联的揭示
Xianmei Wang,Yang Zhang,Yi Ye et al.
Xianmei Wang et al.
Objective: The neutrophil-to-lymphocyte ratio (NLR) is an important marker of inflammation. An increased NLR has been detected in the blood of patients with epilepsy. However, the correlation between varying NLRs and epileptic seizures (ESs...
The Chronobiological and Neuroprotective Mechanisms of Resveratrol in Improving Sleep [0.03%]
白藜芦醇改善睡眠的chrono生物学和神经保护机制
Wenwen Zhu,Ailin Gong,Bin Zhang et al.
Wenwen Zhu et al.
According to statistics, more than one-third of the global population currently experiences sleep problems, and about 10% of adults have been diagnosed with insomnia, a proportion that is increasing annually. Most currently used insomnia me...
Therapeutic Potential of Arginine-Loaded Red Blood Cell Nanovesicles Targeting Obese Asthma [0.03%]
精氨酸加载的红细胞纳米囊泡在肥胖哮喘中的治疗潜力
Quoc Quang Luu,Taejune Kim,Thi Bich Tra Cao et al.
Quoc Quang Luu et al.
Purpose: The role of the gut microbiomes has been emphasized in the pathogenesis of obese asthma (OA). However, the molecular mechanism of airway dysfunction underlying OA has not yet been fully elucidated. The effects of microbiomes on arg...
Baotian Wang,Fan Wang,Li Yang et al.
Baotian Wang et al.
Background: Cerebral palsy (CP) is a debilitating condition characterized by abnormal movement or posture beginning early in development. Recent evidence has shown that immunological abnormalities are associated with an increased risk of CP...
Interleukins-27 Aggravates Liver Injury by Impairing the Antimicrobial Response of Macrophages via the Promotion of Mitochondrial Dysfunction in the Context of Sepsis [0.03%]
白细胞介素27通过促进脓毒症中巨噬细胞的线粒体功能障碍而加重肝脏损伤的一项机制研究
Yuehua You,Yuyan Li,Lin Ye et al.
Yuehua You et al.
Background and Aims: Plasma interleukin (IL)-27 is an important mediator of acute hepatic injury (AHI) associated with sepsis. Mitochondria contribute to the proper regulation of macrophage phagocytosis. In this study, we investigated the e...
Aeroallergen Sensitization Patterns and Related Factors in Children With Allergic Rhinitis in Guangzhou [0.03%]
广州过敏性鼻炎儿童气传过敏原致敏特点及其相关因素分析
Qingxiang Zeng,Chao Yang,Jinyuan Li et al.
Qingxiang Zeng et al.
Background: Certain patterns of children's serum immunoglobulin E (IgE) sensitivity to aeroallergens may offer useful clinical insight into forecasting the course and prognosis of allergic rhinitis (AR). The study aimed to investigate the c...
Taohong Siwu Decoction Combined With the LncRNA H19/miR-675-5p Axis Repairs Limb Ischemia-Reperfusion Injury Through the Regulation of the Wnt3a/Ca2+ Signaling Pathway [0.03%]
桃红四物汤联合LncRNA H19/miR-675-5p轴通过调节Wnt3a/Ca2+信号通路修复肢体缺血再灌注损伤
Fuping Zhu,Hui Liu,Yinsheng Cao et al.
Fuping Zhu et al.
Background: Taohong Siwu decoction (THSWT) has shown therapeutic effects on ischemia/reperfusion injury (IRI). This study tended to investigate the role of THSWT combined with the long non-coding RNA (LncRNA) H19 (H19)/miR-675-5p axis in im...