Nomograms Based on Blood-Based Biomarkers for Predicting Prognosis in Locally Advanced Nasopharyngeal Carcinoma Patients [0.03%]
基于血液标志物的局部晚期鼻咽癌患者预后预测列线图模型
Sisi Wang,Yuhua Feng,Jie Ling et al.
Sisi Wang et al.
Purpose: This study aimed to investigate the prognostic significance of the platelet-to-platelet distribution width ratio (P/PDW), systemic inflammation response index (SIRI), and systemic immune inflammation index (SII) in patients with lo...
Unveiling the Role of GRK2: From Immune Regulation to Cancer Therapeutics [0.03%]
G蛋白偶联受体激酶2(GRK2)的免疫调控及抗癌作用研究进展
Xizhuang Gao,Dehuai Jing,Yaowen Zhang et al.
Xizhuang Gao et al.
G protein-coupled receptors (GPCRs) represent humans' most prominent family of membrane proteins. In contrast, G protein-coupled receptor kinases (GRKs) play a pivotal role in the rapid desensitization of GPCRs. GRK2 is a particularly signi...
Deciphering the Interplay Among Inflammatory Bowel Disease, Gut Microbiota, and Inflammatory Biomarkers in the Risk of Colorectal Cancer [0.03%]
炎症性肠病、肠道微生物组和炎症生物标志物在结直肠癌风险中的相互作用机制解析
Chenyu Luo,Bowen Tian,Yueyang Zhou et al.
Chenyu Luo et al.
Background: Patients with inflammatory bowel disease (IBD) have an elevated colorectal cancer (CRC) risk, though the etiology remains unclear. This study aimed to elucidate the interplay among IBD, gut microbiota (GM), inflammatory biomarke...
Causal Associations of Inflammatory Cytokines With Osteosarcopenia: Insights From Mendelian Randomization and Single Cell Analysis [0.03%]
炎症细胞因子与骨肌减少症的因果关系：来自孟德尔随机化和单细胞分析的见解
Zugui Wu,Jiyong Yang,Yue Zhu et al.
Zugui Wu et al.
Background: Osteosarcopenia, the coexistence of osteoporosis and sarcopenia, poses significant challenges in aging populations due to its dual impact on bone and muscle health. Inflammation, mediated by specific cytokines, is thought to pla...
Faecalibacterium prausnitzii Colonization Attenuates Gut Inflammation and Epithelial Damage in a DSS-Induced Colitis Mice Model [0.03%]
Faecalibacterium prausnitzii定植可减轻DSS诱导的小鼠结肠炎的肠道炎症和上皮细胞损伤
Meng-Chuan Liu,Yu-An Shu,Yu-Chin Wang et al.
Meng-Chuan Liu et al.
Background: Reduction of Faecalibacterium prausnitzii abundance is related to inflammatory bowel diseases (IBDs), and supplement of it exists protective effects. Aim: This study aimed to establish a F. prausnitzii-colonized mouse model and ...
Identification of Crohn's Disease-Related Biomarkers and Pan-Cancer Analysis Based on Machine Learning [0.03%]
基于机器学习的克罗恩病相关生物标志物识别及泛癌分析
Tangyu Yuan,Jiayin Xing,Pengtao Liu
Tangyu Yuan
Background: In recent years, the incidence of Crohn's disease (CD) has shown a significant global increase, with numerous studies demonstrating its correlation with various cancers. This study aims to identify novel biomarkers for diagnosin...
Electroacupuncture Improves Ovarian Function in Rats With Tripterygium Glycoside-Induced Diminished Ovarian Reserve by Promoting the Polarization of M2 Macrophages and Inhibiting Inflammatory Responses [0.03%]
电针通过促进M2型巨噬细胞极化和抑制炎症反应改善雷公藤内酯醇致减卵泡妇女卵巢功能失调研究
Jia Luo,Yantong Qin,Yaoyao Zhu et al.
Jia Luo et al.
Immunoinflammatory responses and macrophage polarisation are crucial for maintaining ovarian function. Moreover, electroacupuncture (EA) has been shown to protect ovarian function. However, the mechanisms by which EA improves ovarian functi...
Mdivi-1 Attenuates Sepsis-Associated Acute Lung Injury by Inhibiting M1 Alveolar Macrophage Polarization and Pyroptosis [0.03%]
Mdivi-1通过抑制M1肺泡巨噬细胞极化和焦亡减轻脓毒症相关急性肺损伤
Xiaoyu Zhang,Hui Fan,Li Su et al.
Xiaoyu Zhang et al.
Background: Dynamin-related protein 1 (DRP1)-dependent mitochondrial fission is a novel target for mitigating inflammatory diseases. This study aims to explore the effects of the DRP1 inhibitor Mdivi-1 on sepsis-induced acute lung injury (A...
Exploring the Relationship Between Immune Cells and Scoliosis by Mendelian Randomization, Colocalization Analysis, and SMR [0.03%]
利用孟德尔随机化、共定位分析和SMR探索免疫细胞与脊柱侧弯的关系
Chaofan Qin,Zhengjian Yan,Qingshuai Yu et al.
Chaofan Qin et al.
Background: Scoliosis is a condition that can have severe consequences for millions of individuals on an annual basis. Current research in this field is increasingly focusing on the role of the immune system in the development of the diseas...
Strain-Dependent Differences in Inflammatory/Immune Activity in Cutaneous Wound Tissue Repair in Rats: The Significance of Body Mass/Proneness to Obesity [0.03%]
大鼠不同品系皮肤伤口组织修复炎性／免疫活性差异及体重／易肥胖倾向的影响意义
Jelena B Kulas,Aleksandra D Popov Aleksandrov,Dusanka D Popovic et al.
Jelena B Kulas et al.
Inflammatory/immune cells and mediators are substantial for wound healing because they orchestrate biological activities in this complex process. Among factors that affect wound healing, obesity, and metabolic diseases are among the most si...