Understanding Human Cerebral Malaria through a Blood Transcriptomic Signature: Evidences for Erythrocyte Alteration, Immune/Inflammatory Dysregulation, and Brain Dysfunction [0.03%]
通过血液转录组学特征了解人类脑型疟疾：红细胞改变、免疫/炎症失调和大脑功能障碍的证据
Sandrine Cabantous,Belco Poudiougou,Aurélie Bergon et al.
Sandrine Cabantous et al.
Background: Cerebral malaria (CM), a reversible encephalopathy affecting young children, is a medical emergency requiring rapid clinical assessment and treatment. However, understanding of the genes/proteins and the biolo...
Significance of Omega-3 Fatty Acids in the Prophylaxis and Treatment after Spinal Cord Injury in Rodent Models [0.03%]
Omega-3脂肪酸在啮齿动物脊髓损伤预防和治疗中的意义
Piotr Wojdasiewicz,Łukasz A Poniatowski,Paweł Turczyn et al.
Piotr Wojdasiewicz et al.
Polyunsaturated fatty acids (ω-3 acids, PUFAs) are essential components of cell membranes in all mammals. A multifactorial beneficial influence of ω-3 fatty acids on the health of humans and other mammals has been observed for many years....
Mast Cell Deficiency Protects Mice from Surgery-Induced Neuroinflammation [0.03%]
肥大细胞缺乏保护小鼠免受手术引起的神经炎症
Xiang Zhang,Hongquan Dong,Fei Wang et al.
Xiang Zhang et al.
Neuroinflammation plays a key role in the occurrence and development of neurodegenerative diseases. Microglia, the resident immune cells in the brain, have been recognized to contribute to neuroinflammation. Previous studies have shown that...
Aplysin Retards Pancreatic Necrosis and Inflammatory Responses in NOD Mice by Stabilizing Intestinal Barriers and Regulating Gut Microbial Composition [0.03%]
Aplysin通过稳定肠道屏障和调节肠道微生物组成来延缓NOD小鼠的胰腺坏死和炎症反应
Ying Liu,Xinyue Cui,Ming-Qing Gao et al.
Ying Liu et al.
Aplysin is a brominated sesquiterpene with an isoprene skeleton and has biological activities. The purpose of this study is to investigate the inhibitory effect of aplysin on spontaneous pancreatic necrosis in nonobese diabetic (NOD) mice a...
Neutrophil Extracellular Traps: Signaling Properties and Disease Relevance [0.03%]
中性粒细胞外 traps：信号属性和疾病相关性
Tiewei Li,Zhengyan Zhang,Xiaojuan Li et al.
Tiewei Li et al.
Neutrophil extracellular traps (NETs) are characterized as extracellular DNA fibers comprised of histone and cytoplasmic granule proteins. NETs were first described as a form of innate response against pathogen invasion, which can capture p...
Mi Zhou,Kan Ze,Liang Hua et al.
Mi Zhou et al.
Background: Cyr61 is considered a novel proinflammatory factor. Gouty arthritis (GA) is a self-limited inflammatory reaction caused by monosodium urate (MSU) crystals. In this study, we assessed the role of Cyr61 in the i...
Overexpression of CXCL14 Alleviates Ventilator-Induced Lung Injury through the Downregulation of PKM2-Mediated Cytokine Production [0.03%]
CXCL14的过表达通过下调PKM2介导的细胞因子生成减轻呼吸机引起的肺损伤
Rui Zhu,Yan-Qing Lei,Dong-Chi Zhao
Rui Zhu
Ventilator-induced lung injury (VILI) is one of the most common complications of mechanical ventilation (MV), which strongly impacts the outcome of ventilated patients. Current evidences indicated that inflammation is a major contributor to...
Yingying Chen,Dan Lu,Alexey Churov et al.
Yingying Chen et al.
Natural killer cells (NK cells) play an important role in innate immunity. NK cells recognize self and nonself depending on the balance of activating receptors and inhibitory receptors. After binding to their ligands, NK cell receptors trig...
Understanding the Role of Exercise in Nonalcoholic Fatty Liver Disease: ERS-Linked Molecular Pathways [0.03%]
理解运动在非酒精性脂肪肝疾病中的作用：与ERS相关的分子通路
Yong Zou,Zhengtang Qi
Yong Zou
Nonalcoholic fatty liver disease (NAFLD) is globally prevalent and characterized by abnormal lipid accumulation in the liver, frequently accompanied by insulin resistance (IR), enhanced hepatic inflammation, and apoptosis. Recent studies sh...
Soluble IL-2 Receptor in Dermatomyositis: Its Associations with Skin Ulcers and Disease Activity [0.03%]
皮肤溃疡和疾病活动度在皮肌炎中的可溶性白介素2受体
Linrong He,Xiaoming Shu,Xia Liu et al.
Linrong He et al.
Objective: To investigate the role of soluble interleukin-2R (sIL-2R) in idiopathic inflammatory myopathies (IIM). Methods: Serum sIL-2...