Segment 2 from influenza A(H1N1) 2009 pandemic viruses confers temperature-sensitive haemagglutinin yield on candidate vaccine virus growth in eggs that can be epistatically complemented by PB2 701D [0.03%]
来自A（H1N1）大流行病毒的节段2使鸡胚中候选疫苗病毒产生温度敏感血凝素，可通过PB2 701D表型上互补
Saira Hussain,Matthew L Turnbull,Rute M Pinto et al.
Saira Hussain et al.
Candidate vaccine viruses (CVVs) for seasonal influenza A virus are made by reassortment of the antigenic virus with an egg-adapted strain, typically A/Puerto Rico/8/34 (PR8). Many 2009 A(H1N1) pandemic (pdm09) high-growth reassortants (HGR...
Amino acids at the exposed C-terminus of the S coat protein of cowpea mosaic virus play different roles in particle formation and viral systemic movement [0.03%]
豆荚病毒S衣壳蛋白暴露的C端氨基酸残基在颗粒形成和病毒系统传播中发挥不同的作用
Yulia Meshcheriakova,George P Lomonossoff
Yulia Meshcheriakova
The icosahedral capsid of cowpea mosaic virus is formed by 60 copies of the large (L) and small (S) coat protein subunits. The 24-amino-acid C-terminal peptide of the S coat protein can undergo proteolytic cleavage without affecting particl...
Whole-genome-based characterization of three human Rotavirus C strains isolated from gastroenteritis outbreaks in Western India and a provisional intra-genotypic lineage classification system [0.03%]
基于全基因组的轮状病毒C三种毒株的特征描述及暂时的系分类系统
Madhuri S Joshi,Atul M Walimbe,Sanmati P Dilpak et al.
Madhuri S Joshi et al.
The number of whole-genome sequences of human rotavirus C (RVC) strains available in public databases is recently increasing. Thus far from India only a single whole genome of human RVC of a sporadic case was available. In this study, nearl...
The broad-spectrum antiviral drug arbidol inhibits foot-and-mouth disease virus genome replication [0.03%]
抗病毒药物阿比多尔抑制口蹄疫病毒基因组复制
Morgan R Herod,Oluwapelumi O Adeyemi,Joseph Ward et al.
Morgan R Herod et al.
Arbidol (ARB, also known as umifenovir) is used clinically in several countries as an anti-influenza virus drug. ARB inhibits multiple enveloped viruses in vitro and the primary mode of action is inhibition of virus entry and/or fusion of v...
HIV-1 restriction by endogenous APOBEC3G in the myeloid cell line THP-1 [0.03%]
髓样细胞系THP-1中内源性APOBEC3G对HIV-1的限制作用
Terumasa Ikeda,Amy M Molan,Matthew C Jarvis et al.
Terumasa Ikeda et al.
HIV-1 replication in CD4-positive T lymphocytes requires counteraction of multiple different innate antiviral mechanisms. Macrophage cells are also thought to provide a reservoir for HIV-1 replication but less is known in this cell type abo...
Mutations in the DI-DII linker of the NDV fusion protein conferred hemagglutinin-neuraminidase-independent cell fusion promotion [0.03%]
NDV融合蛋白DI-DII连接肽区的突变可促进血凝素-神经氨酸酶非依赖性细胞膜融合效应
Miaomiao Chi,Wenyan Xie,Ying Liu et al.
Miaomiao Chi et al.
Newcastle disease (ND), which is caused by Newcastle disease virus (NDV), is a highly contagious disease in chickens and is a great threat to the poultry industry. Fusion of the viral and target cell membranes is a prerequisite for NDV's en...
Whole-genome characterization of G12 rotavirus strains detected in Mozambique reveals a co-infection with a GXP[14] strain of possible animal origin [0.03%]
莫桑比克检测到的G12轮状病毒全基因组特征揭示与可能来源于动物的GXP[14]株共感染
Amy Strydom,Lithabiso Motanyane,Martin M Nyaga et al.
Amy Strydom et al.
A high prevalence of G12 rotavirus strains has previously been reported in southern Mozambique. In this study, the full genomes of five Mozambican G12 strains were determined directly from stool using an Illumina Miseq platform. One sample ...
Fine-tuning expression of begomoviral movement and nuclear shuttle proteins confers cell-to-cell movement to mastreviral replicons in Nicotiana benthamiana leaves [0.03%]
在细小病毒Rep转基因植物中的嫁接病毒表达系统的建立与运用
Andrew G Diamos,John M Crawford,Hugh S Mason
Andrew G Diamos
Geminiviruses are a group of small plant viruses responsible for devastating crop damage worldwide. The emergence of agricultural diseases caused by geminiviruses is attributed in part to their high rates of recombination, leading to comple...
Tmprss2 knock-out mice are resistant to H10 influenza A virus pathogenesis [0.03%]
Tmprss2敲除小鼠对H10流感病毒无病理效应
Ruth L O Lambertz,Ingo Gerhauser,Inga Nehlmeier et al.
Ruth L O Lambertz et al.
The surface protein haemagglutinin (HA) of influenza A viruses (IAV) needs to be cleaved by a host protease to become functional. Here, we investigated if IAV of the H10 subtype also requires TMPRSS2 for replication and pathogenesis in mice...
Virus-like particles in a new vaccination approach against infectious laryngotracheitis [0.03%]
新型疫苗接种方案利用病毒样颗粒对抗传染性喉气管炎
Julia Schädler,Brigitte Sigrist,Simone M Meier et al.
Julia Schädler et al.
Gallid alphaherpesvirus 1 (syn. infectious laryngotracheitis virus; ILTV) is the causative agent of infectious laryngotracheitis, a respiratory disease of chickens causing substantial economic losses in the poultry industry every year. Curr...