Ralf G Dietzgen,Dàohóng Jiāng,Jens H Kuhn et al.
Ralf G Dietzgen et al.
The family Artoviridae was created in 2018 for the established monospecific genus Peropuvirus and six new species of invertebrate viruses that had all been discovered by high-throughput sequencing. Artoviruses have negative-sense RNA genome...
Efficacy of glecaprevir and pibrentasvir treatment for genotype 1b hepatitis C virus drug resistance-associated variants in humanized mice [0.03%]
用于人类化小鼠基因1b型丙肝病毒耐药相关变异株感染的 glecaprevir和pibrentasvir治疗疗效研究
Mitsutaka Osawa,Takuro Uchida,Michio Imamura et al.
Mitsutaka Osawa et al.
Combination therapy with glecaprevir (GLE) and pibrentasvir (PIB) has high efficacy for pan-genotypic hepatitis C virus (HCV)-infected patients. However, the efficacy for patients who acquired potent NS5A inhibitor resistance-associated var...
Sheli R Radoshitzky,Michael J Buchmeier,Rémi N Charrel et al.
Sheli R Radoshitzky et al.
Members of the family Arenaviridae produce enveloped virions containing genomes consisting of two or three single-stranded RNA segments totalling about 10.5 kb. Arenaviruses can infect mammals, including humans and other primates, snakes, a...
Joseph Bujarski,Donato Gallitelli,Fernando García-Arenal et al.
Joseph Bujarski et al.
Bromoviridae is a family of plant viruses with tri-segmented, positive-sense, single-stranded RNA genomes of about 8 kb in total. Genomic RNAs are packaged in separate virions that may also contain subgenomic, defective or satellite RNAs. V...
Evaluation of the role of respiratory syncytial virus surface glycoproteins F and G on viral stability and replication: implications for future vaccine design [0.03%]
评估呼吸道合胞病毒表面糖蛋白F和G对病毒稳定性和复制的作用：对未来疫苗设计的意义
Darby M DeFord,Jenna M Nosek,Katelyn R Castiglia et al.
Darby M DeFord et al.
Respiratory syncytial virus (RSV) remains a leading cause of infant mortality worldwide and exhaustive international efforts are underway to develop a vaccine. However, vaccine development has been hindered by a legacy of vaccine-enhanced d...
Rodrigo A Valverde,Mahmoud E Khalifa,Ryo Okada et al.
Rodrigo A Valverde et al.
The family Endornaviridae includes viruses with linear, single-stranded, positive-sense RNA genomes that range from 9.7 to 17.6 kb and have been reported infecting plants, fungi and oomycetes. The family consists of two genera, Alphaendorna...
Identification of Marek's disease virus genes associated with virulence of US strains [0.03%]
美国毒株传染性的马立克氏病病毒基因鉴定
John R Dunn,Alexis Black Pyrkosz,Alec Steep et al.
John R Dunn et al.
Marek's disease virus (MDV) is the most well-cited example of vaccine-driven virulence evolution. MDV induces a lymphoproliferative disease in chickens, which is currently controlled by widespread vaccination of flocks. Unfortunately, Marek...
Roles of YIGL sequence of Ebola virus VP40 on genome replication and particle production [0.03%]
埃博拉病毒VP40的YIGL序列对基因组复制和颗粒生成的作用
Shuzo Urata,Takeshi Ishikawa,Jiro Yasuda
Shuzo Urata
Ebola virus (EBOV) VP40 is a major driving force of nascent virion production and a negative regulator of genome replication/transcription. Here, we showed that the YIGL sequence at the C-terminus of EBOV VP40 is important for virus-like pa...
Rift Valley fever virus minigenome system for investigating the role of L protein residues in viral transcription and replication [0.03%]
研究L蛋白残基在病毒转录和复制中作用的裂谷热病毒迷你基因系统
Hanna Jérôme,Martin Rudolf,Michaela Lelke et al.
Hanna Jérôme et al.
Replicon systems are important tools for investigating viral RNA synthesis. We have developed an ambisense minigenome system for Rift Valley fever virus (RVFV) with the aim to analyse the effects of L gene mutations on viral transcription v...
The virome of an endangered stingless bee suffering from annual mortality in southern Brazil [0.03%]
巴西南部一种濒临灭绝的土生蜜蜂在每年濒危时期病毒基因组的研究
Lílian Caesar,Samuel Paulo Cibulski,Cláudio Wageck Canal et al.
Lílian Caesar et al.
Meliponiculture - the management of stingless bee colonies - is an expanding activity in Brazil with economic, social and environmental potential. However, unlike in apiculture, the pathogens that impact on meliponiculture remain largely un...