Diaphorina citri densovirus is a persistently infecting virus with a hybrid genome organization and unique transcription strategy [0.03%]
柑橘黄伪粉虱小DNA病毒的基因组组织和转录策略独特
Jared C Nigg,Bryce W Falk
Jared C Nigg
Diaphorina citri densovirus (DcDV) is an ambisense densovirus with a 5071 nt genome. Phylogenetic analysis places DcDV in an intermediate position between those in the Ambidensovirus and Iteradensovirus genera, a finding that is consistent ...
Influenza A/H4N2 mallard infection experiments further indicate zanamivir as less prone to induce environmental resistance development than oseltamivir [0.03%]
禽流感A/H4N2感染试验进一步表明，zanamivir诱导环境抗性发展的倾向小于oseltamivir
Viktoria Tepper,Marie Nykvist,Anna Gillman et al.
Viktoria Tepper et al.
Neuraminidase inhibitors (NAIs) are the gold standard treatment for influenza A virus (IAV). Oseltamivir is mostly used, followed by zanamivir (ZA). NAIs are not readily degraded in conventional wastewater treatment plants and can be detect...
In vitro detection of haematogenous prions in white-tailed deer orally dosed with low concentrations of chronic wasting disease [0.03%]
口服低剂量慢性消耗性疾病白尾鹿的体外血液检测白尾deer感染朊病毒
Erin E McNulty,Amy V Nalls,Randy Xun et al.
Erin E McNulty et al.
Infectivity associated with prion disease has been demonstrated in blood throughout the course of disease, yet the ability to detect blood-borne prions by in vitro methods remains challenging. We capitalized on longitudinal pathogenesis stu...
Holly R Hughes,Scott Adkins,Sergey Alkhovskiy et al.
Holly R Hughes et al.
Peribunyaviruses are enveloped and possess three distinct, single-stranded, negative-sense RNA segments comprising 11.2-12.5 kb in total. The family includes globally distributed viruses in the genera Orthobunyavirus, Herbevirus, Pacuvirus ...
Valentina D&#x;Arienzo,Andrea Magri,James M Harris et al.
Valentina D&#x;Arienzo et al.
Hepatitis B virus (HBV) is the prototype member of the family Hepadnaviridae and replicates via episomal copies of a covalently closed circular DNA (cccDNA) genome of approximately 3.2 kb. The chromatinization of this small viral genome, wi...
Effect of Wolbachia w AlbB on a positive-sense RNA negev-like virus: a novel virus persistently infecting Aedes albopictus mosquitoes and cells [0.03%]
沃尔巴克氏体wAlbB对正链RNA病毒Negev-like病毒的效应：一种新型持续感染蚊虫和细胞病毒的研究
Cameron Bishop,Rhys Parry,Sassan Asgari
Cameron Bishop
The Aedes aegypti mosquito is the primary vector of several medically important arboviruses. The endosymbiotic bacterium, Wolbachia pipientis, has emerged as a means of blocking transmission of arboviruses such as dengue and Zika viruses. O...
Specific diagnostic method for St. Louis encephalitis virus using a non-structural protein as the antigen [0.03%]
一种以非结构蛋白作为抗原的圣路易斯脑炎病毒的诊断方法
Milagros Belén Simari,Sandra Elizabeth Goñi,Victoria Celina Luppo et al.
Milagros Belén Simari et al.
St. Louis encephalitis virus (SLEV) is a mosquito-borne re-emerging flavivirus in Argentina. It is currently necessary to develop specific serological tests that can efficiently discriminate the flaviviruses that circulate in our country. T...
mTORC1 restricts hepatitis C virus RNA replication through ULK1-mediated suppression of miR-122 and facilitates post-replication events [0.03%]
mTORC1通过ULK1介导的miR-122抑制限制HCV RNA复制并促进复制后的事件
Manish Kumar Johri,Hiren Vasantrai Lashkari,Divya Gupta et al.
Manish Kumar Johri et al.
The mechanistic target of rapamycin (mTOR), an important kinase that assimilates several upstream signals, associates into two functional complexes, mTORC1 and mTORC2. In this study, we demonstrate that HCV infection activates mTORC1 that f...
Phenotypic analysis of mutations at residue 146 provides insights into the relationship between NS5A hyperphosphorylation and hepatitis C virus genome replication [0.03%]
针对146位点突变的表型分析揭示了NS5A超磷酸化与HCV基因组复制之间的关系
Niluka Goonawardane,Chunhong Yin,Mark Harris
Niluka Goonawardane
The hepatitis C virus genotype 2a isolate, JFH-1, exhibits much more efficient genome replication than other isolates. Although basic replication mechanisms must be conserved, this raises the question of whether the regulation of replicatio...
Nucleolin (NCL) inhibits the growth of peste des petits ruminants virus [0.03%]
核蛋白核糖体结合蛋白核小体(NCL)抑制小反刍兽疫病毒的增殖
Dandan Dong,Shiqiang Zhu,Qiuhong Miao et al.
Dandan Dong et al.
Peste des petits ruminants (PPR) is a highly contagious disease of small ruminants that is caused by peste des petits ruminants virus (PPRV). To date, the molecular mechanism of PPRV infection is still unclear. It is well known that host pr...