Co-presence of classical scrapie but not classical Bovine Spongiform Encephalopathy in transmissions from Dutch sheep with atypical scrapie [0.03%]
荷兰羊不典型 Scrapie 感染传代中出现经典羊瘙痒病但没有出现经典牛海绵状脑病
Lucien J van Keulen,Corry H Dolstra,Ruth Bossers-de Vries et al.
Lucien J van Keulen et al.
Two cases of atypical scrapie (AS) from Dutch sheep were passaged to WT mice and ovine and bovine prion protein (PrP) transgenic mice. Both AS isolates failed to transmit to WT mice but were successfully transmitted to ovine PrP transgenic ...
Endogenized polinton-like viruses in the dinoflagellate Oxyrrhis marina uncover novel PolB fusion [0.03%]
衣藻类真核生物Oxyrrhis marina中内源化Polintons样病毒发现新的PolB融合形式
Ronie Haro,Lucie Gallot-Lavallée,John M Archibald et al.
Ronie Haro et al.
Marine viruses are ubiquitous entities that impact the biology of a large fraction of prokaryotic and eukaryotic diversity. Dinoflagellates are heterotrophic, mixotrophic and photosynthetic eukaryotes known for their large and complex nucle...
Significant diversity of human anelloviruses revealed by novel viral sequences identified in human metagenomic data [0.03%]
利用人类元基因组数据揭示新型人环状病毒断片及人类环状病毒的多样性
Shaokun Pan,Xingyue Zhao,Qi Shi et al.
Shaokun Pan et al.
Human torque teno viruses are emerging infectious agents distributed globally and have increasingly been reported to be associated with human diseases. To identify potential anelloviral sequences in available metagenomic data, an in silico ...
Broadly neutralizing human monoclonal antibodies against BK polyomavirus genotypes [0.03%]
针对BK多瘤病毒基因型的广谱中和人源单克隆抗体
J Andrew Duty,Thomas A Kraus,Madhu Kumar et al.
J Andrew Duty et al.
BK polyomavirus (BKV) causes polyomavirus-associated nephropathy (BKV-nephropathy) and polyomavirus-associated haemorrhagic cystitis following kidney transplantation and allogeneic haematopoietic stem cell transplantation. BKV strains consi...
Identification and characterization of candidate inhibitors of the SARS-CoV-2 nsp14 3'-5' exoribonuclease [0.03%]
SARS-CoV-2 nsp14 3'-5'外切酶候选抑制剂的鉴定与表征
Victoria Easton,Martin J McPhillie,Igor Andrade Santos et al.
Victoria Easton et al.
Coronaviruses such as SARS-CoV-2 possess the largest positive-sense RNA virus genomes (30 kb). This poses a fidelity problem as the inherent lack of proof-reading capacity of the viral RNA-dependent RNA polymerase results in a high level of...
Repurposing of the bisbenzimide antibiotic Ridinilazole as an antiviral compound against human cytomegalovirus [0.03%]
将抗生素Ridinilazole再利用作为人巨细胞病毒的抗病毒化合物
Hayden Pinto,Katie A Latham,Steve Goodbourn et al.
Hayden Pinto et al.
Novel antiviral drugs targeting DNA viruses are desirable. Previous studies from our laboratory and others have demonstrated that DNA binding bisbenzimide compounds are capable of inhibiting replication of diverse DNA viruses, such as a her...
Thorough characterization of a new curvulavirid from a Japanese strain of Cryphonectria nitschkei [0.03%]
日本Cryphonectria nitschkei分离物中一种新的曲绿藻病毒的全面表征
Sabitree Shahi,Sakae Hisano,Wasiatus Sa&#x;diyah et al.
Sabitree Shahi et al.
A new curvulavirid was isolated from a Japanese strain of the filamentous ascomycete Cryphonectria nitschkei and thoroughly characterized. The virus termed Cryphonectria nitschkei curvulavirus 1 (CnCvV1) has a bi-segmented dsRNA genome. CnC...
Coordinated interactions among Nipah virus N, P and M proteins drive formation of distinct inclusion bodies [0.03%]
Nipah病毒N、P和M蛋白之间的协调作用驱动不同类型包涵体的形成
Mitsuki Yasukochi,Mika Hosogi,Yuki Kitai et al.
Mitsuki Yasukochi et al.
Nipah virus (NiV), a highly pathogenic zoonotic paramyxovirus, forms two distinct types of membrane-less organelles called inclusion bodies (IBs): cytosolic IBs, which serve as sites of viral RNA synthesis, and those beneath the plasma memb...
Small RNA-mediated regulation of cross-kingdom gene expression in sugar beet genotypes resistant and susceptible to rhizomania [0.03%]
糖 Beet抗 Rhizomania 基因型中的 Small RNA 介导的跨界基因表达调控
Evan M Long,Rajtilak Majumdar,Carl A Strausbaugh et al.
Evan M Long et al.
Rhizomania in sugar beet causes significant yield and sucrose loss worldwide. The disease is caused by Beet necrotic yellow vein virus (BNYVV) and vectored by the plasmodiophorid, Polymyxa betae. Resistance to rhizomania in commercial culti...
Development of enterovirus transencapsidation assays as tools to understand viral entry [0.03%]
肠病毒转衣壳测定方法的发展作为了解病毒进入的工具
Philippa K Hall,Natasha Cassani,Eero V Hietanen et al.
Philippa K Hall et al.
Enteroviruses (EVs) are globally important human and animal pathogens that cause a diverse spectrum of diseases, ranging from febrile illness to paralysis. Despite decades of research, parts of the EV lifecycle remain poorly understood. Rep...