Nicola F Fletcher,Luke W Meredith,Emma L Tidswell et al.
Nicola F Fletcher et al.
Some free fatty acids derived from milk and vegetable oils are known to have potent antiviral and antibacterial properties. However, therapeutic applications of short- to medium-chain fatty acids are limited by physical characteristics such...
In vivo comparison of a laboratory-adapted and clinical-isolate-based recombinant human respiratory syncytial virus [0.03%]
实验室适应和临床分离的人呼吸道合胞病毒重组病毒的体内比较研究
Laurine C Rijsbergen,Linda J Rennick,Brigitta M Laksono et al.
Laurine C Rijsbergen et al.
Human respiratory syncytial virus (HRSV) is the leading cause of severe respiratory tract disease in infants. Most HRSV infections remain restricted to the upper respiratory tract (URT), but in a small percentage of patients the infection s...
Antiviral and virucidal effects of curcumin on transmissible gastroenteritis virus in vitro [0.03%]
姜黄素对传染性胃肠炎病毒的抗病毒和灭活作用
Yaoming Li,Jing Wang,Yinchuan Liu et al.
Yaoming Li et al.
Emerging coronaviruses represent serious threats to human and animal health worldwide, and no approved therapeutics are currently available. Here, we used Transmissible gastroenteritis virus (TGEV) as the alpha-coronavirus model, and invest...
The 3A protein of coxsackievirus B3 acts as a viral suppressor of RNA interference [0.03%]
柯萨奇病毒B3的3CD蛋白是一种病毒性RNA干扰抑制因子
Jingfang Mu,Haobo Zhang,Tao Li et al.
Jingfang Mu et al.
RNA interference (RNAi) is a potent antiviral defence mechanism in eukaryotes, and numerous viruses have been found to encode viral suppressors of RNAi (VSRs). Coxsackievirus B3 (CVB3) belongs to the genus Enterovirus in the family Picornav...
Andrew E Firth
Andrew E Firth
Identification of the full complement of genes in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a crucial step towards gaining a fuller understanding of its molecular biology. However, short and/or overlapping genes can be...
Hantavirus infection in type I interferon receptor-deficient (A129) mice [0.03%]
I型干扰素受体缺陷(A129)小鼠中的汉坦病毒天然感染
Stuart D Dowall,Victoria A Graham,Marilyn Aram et al.
Stuart D Dowall et al.
Type I interferon receptor knockout mice (strain A129) were assessed as a disease model of hantavirus infection. A range of infection routes (intramuscular, intraperitoneal and intranasal) were assessed using minimally passaged Seoul virus ...
Bat-borne polyomaviruses in Europe reveal an evolutionary history of intrahost divergence with horseshoe bats distributed across the African and Eurasian continents [0.03%]
揭示欧洲蝙蝠的痘病毒进化历史：跨非洲和欧亚大陆分布的蹄兔科蝙蝠体内宿主内部分化
Márton Z Vidovszky,Zhizhou Tan,Michael J Carr et al.
Márton Z Vidovszky et al.
Polyomaviruses (PyVs) are small, circular dsDNA viruses carried by diverse vertebrates, including bats. Although previous studies have reported several horseshoe bat PyVs collected in Zambia and China, it is still unclear how PyVs evolved i...
High-efficiency nonhomologous insertion of a foreign gene into the herpes simplex virus genome [0.03%]
高效非同源插入外源基因到单纯疱疹病毒基因组中
Yue Gong,Yanwei Bi,Zhihua Li et al.
Yue Gong et al.
Efficient, accurate and convenient foreign-gene insertion strategies are crucial for the high-throughput and rapid construction of large DNA viral vectors, but relatively inefficient and labour-intensive methods have limited the application...
Absence of classical and atypical (H- and L-) BSE infectivity in the blood of bovines in the clinical end stage of disease as confirmed by intraspecies blood transfusion [0.03%]
绵羊水泡性口炎病毒的基因组变异及其对毒力的影响
Anne Balkema-Buschmann,Ute Ziegler,Grit Priemer et al.
Anne Balkema-Buschmann et al.
While the presence of bovine spongiform encephalopathy (BSE) infectivity in the blood of clinically affected sheep has been proven by intraspecies blood-transfusion experiments, this question has remained open in the case of BSE-affected ca...
Mutations in the cytoplasmic domain of dengue virus NS4A affect virus fitness and interactions with other non-structural proteins [0.03%]
登革病毒NS4A胞质区的突变影响病毒的适应度及其与其他非结构蛋白的相互作用
Min Jie Alvin Tan,Nancy G Brown,Kitti Wing Ki Chan et al.
Min Jie Alvin Tan et al.
The dengue virus (DENV) replication complex is made up of its non-structural (NS) proteins and yet-to-be identified host proteins, but the molecular interactions between these proteins are not fully elucidated. In this work, we sought to un...