Remodelling of P-bodies and the cytoskeleton by Orthohantavirus puumalaense (Puumala virus) [0.03%]
普乌马拉病毒对P体和细胞骨架的重塑作用
Hannah Sabeth Schwarzer-Sperber,Annette Petrich,Matthias Schade et al.
Hannah Sabeth Schwarzer-Sperber et al.
Orthohantaviruses are emerging zoonotic pathogens that can cause life-threatening diseases in humans. Their tripartite, negative-sense RNA genome is encapsidated by the viral nucleoprotein, but the subcellular localization and dynamics of t...
No longer uncertain: the validation of tenebrionid insects as hosts of Blattambidensovirus incertum1 isolates by phylogeny and infection studies [0.03%]
不再不确定：通过系统发育和感染研究验证隐翅虫隶属于incertum1的Blattambidensovirus宿主身份
Fang Shiang Lim,Joel González-Cabrera,Johannes A Jehle et al.
Fang Shiang Lim et al.
The mealworm (Tenebrio molitor) is one of the most commonly mass-reared insects for food and feed. Monitoring the health status of commercially reared mealworm populations is of great importance for the early detection of entomopathogens an...
Screening of FDA-approved drugs using a recombinant Cedar virus to improve treatment options for Nipah virus infection [0.03%]
利用重组雪松病毒筛选FDA批准的药物以改善尼帕病毒感染的治疗选项
Emily Clayton,Moushimi Amaya,Dung Nguyen et al.
Emily Clayton et al.
Nipah virus and Hendra virus are highly pathogenic henipaviruses for which there are no approved therapeutics for use in humans. Using recombinant Cedar virus expressing luciferase (rCedV-Luc) as a CL2 surrogate, we screened a library of 2,...
How a chance finding and high-throughput sequencing helped unmask the probable causal agent of Brazilian curly top, a plant disease that disappeared over 70 years ago [0.03%]
一次偶然的发现和高通量测序如何帮助揭开一种在70多年前消失的植物病害——巴西蜷曲顶病的致病原因
Juliana Osse de Souza,Tomas A Melgarejo,Monica Alves Macedo et al.
Juliana Osse de Souza et al.
Curly top disease (CTD) affects sugar beet, tomato and other crops, resulting in stunted plants with severely curled leaves and reduced yields. The disease occurs worldwide and is caused by geographically associated monopartite geminiviruse...
Feline morbillivirus elicits robust neutralizing antibodies in domestic cats without cross-neutralizing activities against canonical morbilliviruses [0.03%]
猫瘟病毒属家猫可引起强烈的中和抗体反应但不具有对典型猫瘟病毒的交叉中和作用
Kaede Tashiro,Kiyotaka Konishi,Eun-Sil Park et al.
Kaede Tashiro et al.
Feline morbillivirus (FeMV), first identified in 2012, is a member of the genus Morbillivirus. Like other morbilliviruses, FeMV utilizes signalling lymphocytic activation molecule (CD150 or SLAMF1) as a cellular receptor; however, it is gen...
Mutant knock-in mice display enhanced susceptibility to pure prion protein fibrils [0.03%]
敲入小鼠对纯朊蛋白纤维的易感性增加
Daniel J Walsh,Heidi Standke,Allison Kraus et al.
Daniel J Walsh et al.
Prion diseases manifest clinically in three different forms. Sporadic and infectious forms of prion disease are caused by the conversion of WT, cellular prion protein (PrPC) into its pathogenic conformer (PrPSc). In contrast, genetic forms ...
HCV infection induces ubiquitin-dependent degradation of LATS1, inactivating the Hippo pathway and upregulating transcription of the CYR61 and CTGF genes [0.03%]
丙型肝炎病毒感染通过泛素-蛋白酶体途径降解LATS1从而活化Hippo信号通路并上调CYR61和CTGF的转录水平
Maria Alethea Septianastiti,Chieko Matsui,Zihan Xu et al.
Maria Alethea Septianastiti et al.
Hepatitis C virus (HCV) is often associated with chronic liver diseases and significant alterations in host cellular signalling. However, the molecular mechanisms underlying HCV-related liver pathogenesis remain to be elucidated. The Hippo ...
Identification of an extremely large-scale genomic rearrangement in the Mpox virus while retaining replicative capacity [0.03%]
鉴定出一种极具规模的马痘病毒基因组重排并保留复制能力
Takayuki Ishige,Eiji Ido,Toshibumi Taniguchi et al.
Takayuki Ishige et al.
Understanding the genomic diversity of the Mpox (formerly known as 'monkeypox') virus (MPXV) is important for monitoring viral evolution and dissemination. We encountered three clinical cases in our hospital during the outbreak period of Mp...
Geographical and temporal trends of HIV-1 subtypes and drug resistance in China: a nationwide study over two decades (2003-2024) [0.03%]
中国HIV-1亚型和耐药的时空分布特征——二十年全国范围调查（2003-2024）
Bin Xie,Zhenggang Wang,Qixiang Song et al.
Bin Xie et al.
Objective. This study aims to characterize the 20-year trends in human immunodeficiency virus 1 (HIV-1) subtypes and circulating recombinant forms (CRFs) in China, as well as patterns of transmitted drug resistance (TDR) to antiretroviral t...
The replicative fitness and virulence of potato virus Y evolve differently in pepper lines with different levels of resistance and tolerance [0.03%]
Potato Y病毒在不同抗病和耐病辣椒品种中的复制适应性和致病性有所不同
Thibaud Jayet,Lucie Tamisier,Marion Szadkowski et al.
Thibaud Jayet et al.
Despite their great agronomic interest and widespread occurrence in germplasm resources, the quantitative resistance and tolerance of plants to their parasites have rarely been studied in terms of durability potential. Using experimental ev...