Optimization of lytic herpes simplex virus infection in human induced pluripotent stem cell-derived cortical neurones [0.03%]
人诱导多能干细胞来源的皮质神经元溶瘤性单纯疱疹病毒感染的优化
Daniel A Nash,Alex S Nicholson,Henry G Barrow et al.
Daniel A Nash et al.
Herpes simplex virus (HSV)-1 infection of cortical neurones is a leading cause of encephalitis. Whilst we have substantial knowledge about the molecular virology of HSV-1 lytic infection in cells of the periphery, like keratinocytes or fibr...
Attenuation mechanisms of the P7-P8 live-attenuated cyvirus cyprinidallo2 vaccine potentially involve apoptosis non-inhibition feature: insights into virus pathogenesis [0.03%]
P7-P8减毒活疫苗潜在的可能通过不抑制细胞凋亡的机制发挥作用：鱼类病毒致病性研究新见解
Hiroaki Saito,Yuki Midorikawa,Takumi Okamura et al.
Hiroaki Saito et al.
Cyvirus cyprinidallo2 (CyHV-2) is an alloherpesvirus and the causative agent of herpesviral haematopoietic necrosis in goldfish. Whole-genome sequence comparison of the developed live-attenuated vaccine P7-P8 with virulent CyHV-2 strains re...
Avian influenza in Ireland: a spatiotemporal, subtype and host-based analysis (1983-2024) [0.03%]
爱尔兰的禽流感：时空、亚型和宿主为基础的分析（1983-2024年）
Maeve Louise Farrell,Guy McGrath,Laura Garza Cuartero et al.
Maeve Louise Farrell et al.
Avian influenza virus (AIV) is a significant global concern, causing widespread mortality in wild birds, domestic poultry and, more recently, wild and domestic mammals. This study presents a retrospective analysis of AIV detections in the R...
Macrophage makeover extreme viral edition: mechanisms of immune subversion and therapeutic perspectives [0.03%]
巨噬细胞改造极端病毒版：免疫逃避机制及治疗对策透视
Zoé Fremont-Debaene,Suzanne Faure-Dupuy
Zoé Fremont-Debaene
Macrophages are versatile innate immune cells that play a crucial role in immune responses and tissue repair. However, their plasticity and central role in immunity also make them prime targets for viral manipulation. Viruses have evolved s...
ICTV Virus Taxonomy Profile: Nipumfusiviridae 2026 [0.03%]
国际病毒分类委员会(ICTV)病毒分类概要：Nipumfusiviridae 2026
Yimin Ni,Yongjie Wang
Yimin Ni
The family Nipumfusiviridae includes DNA viruses with hosts deduced to be marine ammonia-oxidizing archaea, specifically those in the archaeal family Nitrosopumilaceae. Virus genomes have been discovered through metagenomics of samples from...
Amino acid mutations K54E and S154P in the neuraminidase attenuate H3N2 canine influenza virus in mice [0.03%]
犬流感病毒神经氨酸酶上的氨基酸变异K54E和S154P可降低H3N2毒株的致病性
Xue Pan,Xiaona Shi,Luxiang Zhao et al.
Xue Pan et al.
Dogs are considered mixing vessels for influenza viruses, posing a pandemic potential via viral reassortment. Our previous studies indicated that the avian-origin H3N2 canine influenza virus (A/canine/Zhejiang/1/2010, abbreviated C1) is vir...
Isolation, characterization and genomic analysis of a novel lytic bacteriophage EcoPhCCP1, capable of infecting multiple strains of multidrug-resistant Escherichia coli recovered from urinary tract infections [0.03%]
一种新型的EcoPhCCP1噬菌体的分离、表征及基因组分析，该噬菌体能够感染多种多重耐药的大肠杆菌菌株（分离自泌尿道感染）
Boris Parra,Maximiliano Sandoval,Maximiliano Matus-Köhler et al.
Boris Parra et al.
There is an urgent need for alternative solutions to combat multidrug-resistant (MDR) E. coli infections. In recent years, there has been an increase in MDR strains causing urinary tract infections (UTIs), which has resulted in more challen...
Virulence of Marek's disease virus in Japan is linked to polymorphisms in the meq oncogene [0.03%]
家禽马立克氏病病毒的致病性与meq基因多态性的关系研究
Yoshinosuke Motai,Aoi Kurokawa,Jumpei Sato et al.
Yoshinosuke Motai et al.
Marek's disease virus (MDV) causes lymphomas and neurological disorders in chickens. Although vaccination largely controls outbreaks, highly virulent strains continue to emerge. The major MDV-encoded oncoprotein is Meq, functions as a trans...
Impact of a naturally occurring hepatitis B virus genotype D-specific core-promoter mutation on viral replication [0.03%]
一种天然存在的乙型肝炎病毒D基因型特异的核心启动子突变对病毒复制的影响
Masatake Kanai,Tadasu Shin-I,Tomoko Date et al.
Masatake Kanai et al.
Hepatitis B virus (HBV) infects human populations worldwide. HBV strains are classified into 10 genotypes, of which the HBV genotype D (HBV/D) infection is particularly prevalent in several countries. The HBV core promoter regulates viral r...
RNA interference screen against SARS-CoV-2 identifies proviral vesicular transport factors involved in release [0.03%]
针对SARS-CoV-2的RNA干扰筛选鉴定出参与释放作用的宿主促进病毒囊泡运输因子
Holly E M Kerr,Alison Daniels,Sarah L Fletcher et al.
Holly E M Kerr et al.
Identifying host factors of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is paramount to understanding the replication cycle and developing host-targeting antivirals. However, most host factor screens are significantly biass...