A G57 (BJ/94-like) H9N2 avian influenza virus exhibits enhanced replication and tissue dissemination in chickens compared with a G1-B virus [0.03%]
与G1-B病毒相比，G57（BJ/94样）H9N2禽流感病毒在鸡体内的复制和组织播散能力增强
Sushant Bhat,Jean-Remy Sadeyen,Jiayun Yang et al.
Sushant Bhat et al.
Avian influenza H9N2 viruses cause economic losses to the poultry industry and pose a public health risk. Two major H9N2 lineages dominate globally: the G1 lineage (genotype G1-B), prevalent in the Middle East, Africa and South Asia, and th...
Infectivity of recombinant Torque teno sus virus 1 in pigs coinfected with swine influenza virus [0.03%]
重组猪 torque teno 病毒 1 型与猪流感病毒 coinfection 感染猪的感染性研究
Md-Tariqul Islam,Angela Pillatzki,Brett Webb et al.
Md-Tariqul Islam et al.
Torque teno viruses (TTVs) are small non-enveloped DNA viruses that are ubiquitous among mammalian species. Although their pathogenic potential remains uncertain, TTVs can modulate host immunity and potentiate coinfecting pathogens or comor...
Jenna Schafers,Caroline J Warren,Jiayun Yang et al.
Jenna Schafers et al.
In late 2023, H5N1 high-pathogenicity avian influenza virus (HPAIV) started circulating in dairy cattle in the USA. High viral titres were detected in milk from infected cows, raising concerns about onward human infections. Although pasteur...
Copper(II) benzyloxychalcone analogues as new potential metallodrugs against SARS-CoV-2 replication [0.03%]
茋类苯基肉桂酮铜(II)衍生物抗SARS-CoV-2复制的体外研究
Igor Andrade Santos,Victoria Riquena Grosche,Laiane Dos Santos Oliveira et al.
Igor Andrade Santos et al.
Chalcones, a naturally occurring class of molecules found in various plants, serve as both precursors and final products in the biosynthesis of flavonoids. Renowned for their diverse therapeutic actions, chalcones demonstrate anti-inflammat...
The MNV-1 protease-polymerase precursor cleaves a novel site in the NS1-2 protein [0.03%]
MNV-1蛋白酶-聚合酶前体在NS1-2蛋白上切割新位点
Vernon K Ward,Geena M McKenzie-Goldsmith,Matt J Edwards et al.
Vernon K Ward et al.
Human noroviruses (HuNVs) are members of the Caliciviridae family and are a significant cause of gastroenteritis worldwide. Cell culture models are challenging for studying the intracellular replication of HuNV, with murine norovirus (MNV) ...
Co-release of tick-borne encephalitis virus RNA and structural proteins via virus-like particles and extracellular vesicles [0.03%]
通过病毒样颗粒和细胞外囊泡共同释放蜱传脑炎病毒RNA和结构蛋白
Ivana Křížová,Anna Klimešová,Alžběta Dostálková et al.
Ivana Křížová et al.
Tick-borne encephalitis virus (TBEV) is a medically important flavivirus that causes severe neurological diseases in humans. The assembly of flaviviruses is initiated by the interaction between capsid (C) proteins and viral genomic RNA, yet...
Double-edged sword: flavivirus NS1 enhances human plasmin-mediated fibrinolysis while being targeted for cleavage and inactivation [0.03%]
双刃剑：黄病毒NS1蛋白促进人纤溶酶介导的纤维蛋白溶解的同时被切割失活
Lucas Mendes-Monteiro,Pedro Henrique Carneiro,Jonas N Conde et al.
Lucas Mendes-Monteiro et al.
Dengue virus (DENV) is the most prevalent arbovirus in the world, being transmitted to humans through the bite of infected Aedes mosquitoes. Symptomatic individuals may develop a haemorrhagic fever leading to plasma leakage, hypovolaemic sh...
Apoorva Prabhu,Christian Rinke
Apoorva Prabhu
Members of the family Satyavativiridae are dsDNA viruses associated with the host Poseidoniales, a marine archaeal lineage. Genomes assigned to this group have been identified via long-read sequencing of brackish estuarine samples. These vi...
Broadly neutralizing monoclonal antibodies derived from mRNA LNP immunization exhibit potent neutralizing ability against JN.1, KP.3.1.1 and XEC new Omicron variants [0.03%]
由mRNA脂质纳米颗粒免疫产生的广泛中和单克隆抗体对新的Omicron变异株JN.1、KP.3.1.1 和XEC表现出强大的中和能力
Hsiao-Ling Chiang,Hsiu-Ting Lin,Wan-Yu Chen et al.
Hsiao-Ling Chiang et al.
Since the emergence of severe acute respiratory syndrome coronavirus 2 Omicron, dramatic changes in the receptor-binding domain have allowed for virus escape from many therapeutic antibodies. Development of antibodies effective against curr...
Synergistic antiviral effect of host Adipose Triglyceride Lipase-directed DABPU-DE with coronavirus RNA-dependent RNA polymerase-targeting remdesivir on feline infectious peritonitis virus [0.03%]
去脂 triglyceride lipase 介导的 DABPU-DE 与冠状病毒 RNA 依赖性 RNA 聚合酶靶向瑞德西韦联用对猫传染性腹膜炎病毒的协同抗病毒作用
Shaimaa Aboelmagd,Seok In Han,Ragab Farouk et al.
Shaimaa Aboelmagd et al.
Feline infectious peritonitis virus (FIPV) poses a significant threat to cats worldwide. Besides the limited development of antiviral drugs that mainly target virus proteins, concerns about resistance to mutant strains - similar to those se...