Sex-dependent impairment of antibody responses to tick-borne encephalitis virus vaccination and infection in obese mice [0.03%]
肥胖小鼠对蜱传脑炎病毒疫苗和感染的抗体反应受损具有性别差异性
Michal Dvorak,Dominik Arbon,Jiri Salat et al.
Michal Dvorak et al.
Obesity is a growing global health concern with profound effects on immune function and vaccine efficacy. This study investigated the impact of obesity on immune responses to tick-borne encephalitis virus (TBEV) vaccination and infection us...
Immunogenicity of a trivalent haemorrhagic fever vaccine candidate against Sudan virus, Marburg virus and Lassa virus in an mpox vaccine [0.03%]
一种三价出血热疫苗候选疫苗针对苏丹病毒、马堡病毒和拉沙病毒的免疫原性研究及其在猴痘疫苗中的应用
Martina Pfranger,Nina Krause,Benedikt Asbach et al.
Martina Pfranger et al.
A multivalent vaccine targeting high-consequence infectious diseases in Sub-Saharan Africa (SSA), which are linked to high mortality, morbidity and overlapping clinical manifestations, would significantly improve health security and economi...
An Autographa californica multiple nucleopolyhedrovirus-encoded microRNA, AcMNPV-miR-5, downregulates the expression of viral gene ac66 [0.03%]
一种由甘蓝夜蛾多角体病毒编码的微小RNAs AcMNPV-miR-5通过抑制病毒基因ac66的表达来降低病毒复制晚期蛋白的翻译和产量
Tingkai Teng,Zhuowen Duan,Ang Li et al.
Tingkai Teng et al.
Four Autographa californica multiple nucleopolyhedrovirus (AcMNPV)-encoded microRNAs (miRNAs) have been characterized previously. Here, we report the fifth AcMNPV-encoded miRNA, AcMNPV-miR-5 (Ac-miR-5), which downregulates the viral gene ac...
Intrinsic features of rice stripe virus cap-snatching revealed by a minimal RNP-based in vitro transcription system [0.03%]
基于最小RNP的体外转录系统揭示了水稻条纹病毒劫持宿主5'帽的内在特征
Liangheng Tian,Wenzhong Lin,Shuangping Li et al.
Liangheng Tian et al.
Transcription of segmented negative-sense RNA viruses (sNSVs) like rice stripe virus (RSV) is initiated by cap-snatching, where the viral RNA-dependent RNA polymerase cleaves host mRNAs ~10-20 nucleotides downstream of the 5' cap to generat...
Corrigendum: The feline calicivirus capsid protein VP1 is a client of the molecular chaperone Hsp90 [0.03%]
关于分子伴侣Hsp90是杯状病毒衣壳蛋白VP1客户的校正文章
Carolina Pérez-Ibáñez,Yoatzin Peñaflor-Téllez,Carlos Emilio Miguel Rodríguez et al.
Carolina Pérez-Ibáñez et al.
Published Erratum
The Journal of general virology. 2025 Sep;106(9). DOI:10.1099/jgv.0.002158 2025
Pyruvate kinase M2 modulates Japanese encephalitis virus replication in neuronal cells [0.03%]
丙酮酸激酶M2调节日本脑炎病毒在神经元细胞中的复制
Vijay Singh Bohara,Atharva Deshmukh,Sachin Kumar
Vijay Singh Bohara
Japanese encephalitis is a neuroinflammatory condition caused by the Japanese encephalitis virus (JEV). Pyruvate kinase muscle isozyme M2 (PKM2) is a key modulator of glucose metabolism. The role of PKM2 in the autoimmune response and infla...
Temporal dynamics of koala retrovirus plasma RNA load in relation to faecal glucocorticoid metabolites and Chlamydia infection [0.03%]
考拉逆转录病毒血浆RNA负荷的动态变化与粪便皮质类固醇代谢物和沙眼衣原体感染的关系研究
Michaela D J Blyton,Tamara Keeley,Lewis McKillop et al.
Michaela D J Blyton et al.
Koala retrovirus (KoRV) is endemic throughout northern koala populations that are currently in steep decline. We have previously found a strong association between KoRV plasma RNA loads and the risk of secondary diseases, including chlamydi...
Susceptibility of different mouse strains to SARS-CoV-2 spike receptor-binding domain protein-induced lung inflammation: a comparative study [0.03%]
不同小鼠品系易感SARS-CoV-2刺突蛋白受体结合结构域诱导的肺部炎症：一项比较研究
Yujeong Ha,Young Hyun Lee,Hyo-Sung Jo et al.
Yujeong Ha et al.
Transgenic mice expressing human angiotensin-converting enzyme 2 (hACE2) are widely used in research on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) due to their susceptibility to viral infection. However, the extent to whic...
Comparative Study
The Journal of general virology. 2025 Sep;106(9). DOI:10.1099/jgv.0.002148 2025
Pigeons exhibit low susceptibility and poor transmission capacity for H5N1 clade 2.3.4.4b high pathogenicity avian influenza virus [0.03%]
pigeons对H5N1禽流感病毒2.3.4.4b分支低易感并呈现较差的传播能力
Cecilia Di Genova,Caroline J Warren,Simon Johnson et al.
Cecilia Di Genova et al.
The ongoing panzootic of H5N1 high pathogenicity avian influenza virus (HPAIV) has caused the deaths of over half a billion wild birds and poultry and has led to spillover events in both wild and domestic mammals, alongside sporadic human i...
PUM2 binds SARS-CoV-2 RNA and PUM1 mildly reduces viral RNA levels, but neither protein affects progeny virus production [0.03%]
PUM2结合SARS-CoV-2 RNA，而PUM1可轻度降低病毒RNA水平，但两种蛋白均不影响子代病毒的产生
Nhi Phan,Yelizaveta Zaytseva,Chia-Ching Lin et al.
Nhi Phan et al.
Pumilio proteins (PUM1 and PUM2) are essential post-transcriptional regulators of gene expression found across plants, animals and yeast. They bind Pumilio response elements (PREs) on messenger RNAs (mRNAs) to modulate mRNA stability and tr...