A set of genetic tools for use in Clostridioides difficile and related species [0.03%]
难辨梭菌及其他相关物种的基因工具集
Hannah Fisher,Laurence de Lussy Kubisa,Anirudh Jakhmola et al.
Hannah Fisher et al.
The Clostridia are a phylogenetically diverse group of anaerobic, spore-forming bacteria that include species of medical, veterinary and industrial importance. The last two decades have seen major advances in our understanding of Clostridia...
Hypoxia-induced production of the cyclolipodepsipeptide BE-43547 by Micromonospora sp. RV43 [0.03%]
缺氧诱导Micromonospora sp. RV43产生环脂肽类BE-43547
Marie Selch Tvilum,Camilla Bak Nielsen,Iben Steensgaard et al.
Marie Selch Tvilum et al.
The urgent need for new antibiotics emphasizes the importance of investigating the many biosynthetic gene clusters that remain silent under standard culture conditions and of assigning functions to the many natural products already discover...
Charles J Dorman
Charles J Dorman
DNA in most bacterial cells is maintained in an underwound state. The DNA double helix responds to underwinding by adopting a minimum energy conformation through the supercoiling of the duplex, the formation of local single-stranded bubbles...
David A Stevens
David A Stevens
Coccidioidomycosis has long been regarded as one of the most difficult mycoses to eradicate in patients with progressive infection. There are few published studies of inhibition of Coccidioides in vitro, comparing the results with various d...
Microbe Profile: Candidozyma auris: an emergent and resilient yeast and new antifungal strategies [0.03%]
模式微生物概况：耳道坎迪酵母：一种新兴且难以对付的真菌及新的抗真菌策略
Gordon Ramage,Leighann Sherry,Ryan Kean
Gordon Ramage
Candidozyma auris is an emerging opportunistic yeast that is important because of its multidrug resistance, persistence in healthcare environments and ability to cause outbreaks. Since its discovery in 2009 in Japan, it has rapidly spread w...
Divergent and overlapping roles of homospermidine and spermidine in Sinorhizobium meliloti physiology and symbiotic performance [0.03%]
类泛素多胺齐边孢菌素和腐胺在根瘤菌生理和共生性能中的发散与重叠作用研究
Víctor A Becerra-Rivera,Alejandra Arteaga Ide,Alma R Reyes-González et al.
Víctor A Becerra-Rivera et al.
Unlike most rhizobia, Sinorhizobium meliloti produces spermidine (Spd) in addition to putrescine (Put) and homospermidine (HSpd) as soluble intracellular polyamines. To investigate their roles, we analysed S. meliloti Rm8530 mutants lacking...
Synergistic interactions of ruthenium-based carbon monoxide-releasing molecules and antibiotics in their effects on Escherichia coli [0.03%]
类碳单ioxide释放分子与抗生素对大肠杆菌的协同作用研究
Salar Ali,Lauren K Wareham,Robert K Poole et al.
Salar Ali et al.
The emergence of antibiotic-resistant pathogenic bacteria poses a major and growing public health risk. Because antibiotics act on specific molecular targets, bacteria may evolve resistance mechanisms that alter or bypass these targets. Thi...
D-amino acid substitution and cyclization enhance the stability and antimicrobial activity of arginine-rich peptides [0.03%]
D-氨基酸替代和环化增强精氨酰丰富肽的稳定性和抗菌活性
Bruno Mendes,Valeria Castelletto,Ian W Hamley et al.
Bruno Mendes et al.
Cationic peptides, particularly those rich in arginine and/or lysine residues, are usually promising antimicrobial agents effective at low concentrations in laboratory settings. However, their applicability in pharmaceutics and biotechnolog...
Molecular surveillance of foodborne bacterial pathogens and resistome in food products from Hong Kong [0.03%]
香港食品中食源性细菌病原体和耐药基因组的分子监测研究
Qiao Hu,Lianwei Ye,Tao Zang et al.
Qiao Hu et al.
Foodborne infections pose an increasing public health challenge worldwide. The problem has been aggravated by the dissemination of antimicrobial resistance genes among zoonotic pathogens, which results in a sharp increase in antibiotic resi...
Microbial Primer: Ancientbiotics - making modern antimicrobials from historical infection remedies [0.03%]
古生物 primer：古代抗菌药——用历史上的感染疗法制造现代抗菌药物
Freya Harrison,Oluwatosin Q Orababa
Freya Harrison
The modern antibiotic era began in the early twentieth century, but humans have long used materials from the natural world to attempt to treat the symptoms of infection. In this primer, we will discuss the rationale for attempting to recons...