Clinical Rel mutations that increase basal (p)ppGpp promote conjugal transfer of staphylococcal resistance plasmids [0.03%]
临床Rel变体可增加基线(p)ppGpp并促进金黄色葡萄球菌耐药质粒的接合转移
Ashley T Deventer,Ava Sutherland,Daria Biernacka et al.
Ashley T Deventer et al.
Conjugative transfer of plasmids represents a major route through which antibiotic resistance genes are spread. In the case of the prevalent and deadly pathogen Staphylococcus aureus, more than 90% of clinical isolates carry at least one pl...
Sarah Marde Mehdiabad,John J Welch,Lucy A Weinert et al.
Sarah Marde Mehdiabad et al.
Bacterial pathogens can increase transmission opportunities by surviving in the external environment, but despite wide variation in this ability, the drivers of such differences remain poorly understood. Here, we comparatively analysed data...
K C King,C M Saad-Roy,D Coombs et al.
K C King et al.
Host-driven remodelling of the Staphylococcus aureus cell envelope: mechanisms, consequences and therapeutic implications [0.03%]
金黄色葡萄球菌细胞包膜的宿主驱动重塑：机制、后果和治疗意义
Elizabeth V K Ledger
Elizabeth V K Ledger
Staphylococcus aureus is a leading cause of life-threatening infections worldwide and remains difficult to treat despite the availability of antibiotics. The bacterial cell envelope is central to S. aureus pathogenesis as it forms the prima...
Urogenital infections select for reduced ability to grow in a low-iron environment and reduced blood survival for Staphylococcus aureus [0.03%]
尿生殖道感染会使得金黄色葡萄球菌在低铁环境中的生长能力减弱并且减少其进入血液的几率
Kate P Kearney,Elizabeth V K Ledger,Mario Recker et al.
Kate P Kearney et al.
Immunity through nutrient sequestration is one of the means by which a host can protect itself from infection. As a consequence, many micro-organisms have evolved strategies to overcome this, including the opportunistic pathogen Staphylococ...
Metagenomic insight into the diversity and biogeochemical functions of microbial communities in the maar tropical Lake Atexcac [0.03%]
墨西哥 Maar 热带Lake Atexcac 中微生物群落多样性和生物地球化学功能的元基因组学见解
Rodrigo Hernández-Velázquez,Justo Salvador Hernández-Avilés
Rodrigo Hernández-Velázquez
Warm monomictic maar lakes in tropical regions represent dynamic systems where thermal stratification generates strong vertical gradients in oxygen availability and redox conditions, shaping microbial community structure and function. Lake ...
Shaken batch cultures of Pseudomonas aeruginosa contain biofilm-like heterogeneity [0.03%]
振荡批培养中的铜绿假单胞菌含有类似生物被膜的异质性
B G Fritz,M H Christensen,L Heiland et al.
B G Fritz et al.
Two potential sources of differentially tolerant subpopulations of Pseudomonas aeruginosa in batch cultures are aggregation and growth rates. Here, we dissected these effects by treating batch cultures with tobramycin, colistin and a combin...
Metabolic reprogramming promotes Staphylococcus aureus serum resistance [0.03%]
代谢重组可促进金黄色葡萄球菌的血清抵抗性
Samuel J Fenn,Edward J A Douglas,Ruth C Massey
Samuel J Fenn
Staphylococcus aureus is a leading cause of bloodstream infections causing an estimated 300,000 deaths worldwide. Using a functional genomics approach, our group previously identified that adaptation of S. aureus to human serum is polygenic...
Experimental evolution reveals adaptive pathways to reduced antibiotic susceptibility in Pseudomonas aeruginosa biofilms [0.03%]
实验进化揭示了粘液型铜绿假单胞菌生物膜适应降低抗生素敏感性的途径
Fauve Vergauwe,Andrea Sass,Abhinav Madduri et al.
Fauve Vergauwe et al.
In the present study, we used an experimental evolution approach to investigate how reduced antibiotic susceptibility develops in biofilms formed by Pseudomonas aeruginosa when they are exposed to the clinically relevant antibiotics tobramy...
Defining the OrrA regulon and its role in development and antibiotic production in Streptomyces venezuelae NRRL B-65442 [0.03%]
界定OrrA调控子及其在施氏放线菌NRRL B-6544发育和抗生素产生中的作用
Kelly-Rose Tulley,Lucas Balis,Neil A Holmes et al.
Kelly-Rose Tulley et al.
Streptomyces bacteria have complex life cycles involving hyphal growth, sporulation and the production of diverse specialised metabolites, including antibiotics. In this study, we investigated the role of the highly conserved orphan respons...