Bogland plant Tormentil inhibits multidrug-resistant pathogen growth and potentiates antibiotics by disrupting iron homeostasis [0.03%]
抗多药耐药病原菌生长及通过破坏铁稳态来增强抗生素功效的沼泽植物Tormentill
Kavita Gadar,Maria Pigott,Cillian Jacques Gately et al.
Kavita Gadar et al.
The antibiotic resistance crisis has created an urgent need for the development of novel therapeutic strategies to tackle recalcitrant infections. In this study, we identified Tormentil [Potentilla erecta (L.) Raeusch.], a plant that has be...
Decoding the functional role of the calcium ATPase YloB in microbially induced calcite precipitation and sporulation in Solibacillus silvestris [0.03%]
溶杆菌素诱导文石沉淀和孢子形成的钙依赖性ATP酶YloB的功能作用机制研究
Michael Seidel,Julia Bauer,Carsten Geiß et al.
Michael Seidel et al.
Calcium homeostasis is essential for bacterial physiology, yet its regulation and role in specialized processes such as microbially induced calcite precipitation (MICP) and sporulation remain poorly understood. Here, we characterized the so...
Pseudomonas aeruginosa gene expression changes during established biofilm infection in a cystic fibrosis lung model [0.03%]
绿脓杆菌在囊性纤维化肺模型的成熟生物膜感染过程中基因表达变化
Niamh E Harrington,Freya Allen,Ramón Garcia Maset et al.
Niamh E Harrington et al.
The opportunistic pathogen Pseudomonas aeruginosa forms biofilm infections in the lungs of people with the genetic condition cystic fibrosis (CF) that can persist for decades. There are numerous P. aeruginosa lifestyle changes associated wi...
Antifungal activity of the antimicrobial peptide RP557 against priority fungal pathogens [0.03%]
抗微生物肽RP557对优先真菌病原体的抗真菌活性
Vanice Rodrigues Poester,Melissa Orzechowski Xavier,Jéssica Estefania Dávila Hidalgo et al.
Vanice Rodrigues Poester et al.
Background. Natural host defence molecules, part of innate immunity and the first line of defence, are evolutionarily conserved. Some pharmaceutical properties undesirable for clinical use led to the rational design of synthetic molecules w...
Alexis Vargas,Hunter J Kuhlemeier,Nicholas P Cianciotto
Alexis Vargas
Previously, it was demonstrated that a chitinase (ChiA) secreted by the Legionella pneumophila type II secretion system (T2SS) degrades mucin, thereby facilitating bacterial movement through a mucin layer. Here, we discovered that the addit...
Pathogens as commensals: microbial priming of the immune system and heterologous protection [0.03%]
病原体作为共生体：微生物对免疫系统的诱导与异源保护作用
Thomas Belcher,Emily J Stevens
Thomas Belcher
Exposure to microbes is essential to promote the development of the host's immune system. Commensal microbes (i.e. the microbiota) which are acquired early in life play a vital role in immune priming. Whilst many organisms within the microb...
Regulation of mixotrophy in Synechocystis by a rhomboid protease [0.03%]
Synechocystis中的类天冬氨酸内肽酶通过调节双养现象以促进固氮作用
Iskander M Ibrahim,Dale Harrison,Modesta Blunskyte-Hendley et al.
Iskander M Ibrahim et al.
The intramembrane 'rhomboid' protease family is almost ubiquitous across evolution, with its well-conserved transmembrane domains typified in crystal structures of bacterial representatives, such as the Escherichia coli GlpG. In contrast wi...
Differential endopeptidase requirements during adaptation to changing growth conditions in Vibrio cholerae [0.03%]
霍乱弧菌适应生长环境变化过程中外肽酶的调节作用
Kelly Rosch,Upasana Basu,Samantha Lei et al.
Kelly Rosch et al.
The bacterial cell wall is a covalently linked meshwork of peptidoglycan (PG) that helps maintain cell shape and prevents osmotic lysis. This structure must be flexible enough to accommodate transenvelope protein complexes, but strong enoug...
Corrigendum: Interpretation guidance for MHRA regulatory considerations for phage therapeutic products [0.03%]
关于MHRA噬菌体治疗产品监管考量解释说明的勘误表
Carmen Coxon,Elizabeth Bell,Evelien Adriaenssens et al.
Carmen Coxon et al.
Published Erratum
Microbiology (Reading, England). 2026 Feb;172(2):001670. DOI:10.1099/mic.0.001670 2026
Regulation of proteolysis of the sigma factor RpoS by the Gac-Rsm signal transduction system in Azotobacter vinelandii [0.03%]
Gac-Rsm信号转导系统对Azotobacter vinelandii中σ因子RpoS的蛋白酶体降解的调节作用
Juliana Berenice Rojo-Rodríguez,Soledad Moreno,Guadalupe Espin
Juliana Berenice Rojo-Rodríguez
In Azotobacter vinelandii, the sigma factor RpoS is maintained at low levels in exponentially growing cells due to degradation mediated by the chaperone-protease complex ClpXP, while high levels are observed in the stationary phase. This st...