Characterizing microbiomes of African fermented foods in a global context [0.03%]
非洲发酵食品的微生物组特征及其在全球背景下的意义
John Leech,Yemisi D Obafemi,Samuel Breselge et al.
John Leech et al.
Fermentation plays a vital role globally, shaping traditional diets and enhancing food preservation, nutrition and flavour. With over 5,000 varieties of fermented foods globally, the microbiomes of many of these have yet to be explored, par...
Microbial Primer: Bacterial metallophores - their role for metal homeostasis and social interactions [0.03%]
微生物导读：细菌金属螯合物——它们在金属稳态及社会互动中的作用
Clémentine Laffont,Rolf Kümmerli
Clémentine Laffont
Metals are essential trace elements for almost all organisms including bacteria. Yet, metals are toxic at high concentrations, requiring fine-tuned regulatory mechanisms to steer metal homeostasis inside cells. In this primer, we explain ho...
Tracking the early spatio-temporal dynamics of phytoplasma multiplication within its leafhopper vector [0.03%]
追踪植原体在其飞虱媒介体内早期的空间和时间动态变化
Valeria Trivellone,Francesca Canuto,Giulia Lucetti et al.
Valeria Trivellone et al.
Transmission of phytoplasmas, recalcitrant, yet-to-be-cultivated bacteria, by insect vectors depends on acquisition and subsequent pathogen multiplication within the insect body. However, the influence of acquisition duration on early colon...
Atypical catabolite repression of Geobacillus kaustophilus iol operons in the presence of ribose [0.03%]
核糖存在时Geobacillus kaustophilus iol操纵子的非典型分解代谢阻遏作用
Ken-Ichi Yoshida,Kaho Fukui,Takuma Osawa et al.
Ken-Ichi Yoshida et al.
Geobacillus kaustophilus HTA426 is a thermophilic Gram-positive bacterium that encodes the myo-inositol-inducible iol operons, the products of which form the myo-inositol catabolic pathway. Strain PS8 is a mutant of HTA426 that is defective...
Identification of a core set of Campylobacter jejuni flagella modification genes and a reversible non-motile maf3 phenotype [0.03%]
鉴定一组核心的空肠弯曲菌鞭毛修饰基因及maf3非致病表型
Lickson Munjoma,Christopher D Bayliss
Lickson Munjoma
Assembly of flagella filaments in Campylobacter jejuni requires post-translational O-glycosylation of the flagellin proteins with pseudaminic acid, legionaminic acid and related derivatives. This species is unusual as the addition of pseuda...
Phages for One Health: regulatory and product life cycle considerations [0.03%]
噬菌体与人类健康：监管和产品生命周期考量
Liberty Duignan,Evelien M Adriaenssens,Rosanna C T Wright et al.
Liberty Duignan et al.
There is growing interest in bacteriophage (phage) technologies across the One Health spectrum. The UK Parliament's Science, Technology and Innovation Select Committee recently published the results of its inquiry into 'the antimicrobial po...
In vitro evaluation of the antimicrobial activity of chlorhexidine alone or in combination with ketoconazole or miconazole against clinical isolates of Malassezia pachydermatis and multidrug-resistant Staphylococcus pseudintermedius [0.03%]
氯己定单独使用或与酮康唑或咪康唑联合应用对临床分离的马尔尼菲青霉菌和多重耐药中间型金黄色葡萄球菌的体外抗微生物活性评估
Gianna Goldman,Domenico Santoro
Gianna Goldman
Background. Staphylococcus pseudintermedius (SP) and Malassezia pachydermatis (MP) are common causes of canine skin infections associated with increasing antimicrobial resistance. Topical products containing chlorhexidine and azoles have be...
Metabolic perturbation reduces antibiotic tolerance in Mycobacterium tuberculosis [0.03%]
代谢紊乱可降低结核分枝杆菌的抗生素耐受性
Chen-Yi Cheung,Imogen Samuels,Hannah R Klaus et al.
Chen-Yi Cheung et al.
Mycobacterium tuberculosis is tolerant to many antibiotics, leading to impaired antibiotic killing. Using CRISPR interference (CRISPRi) transcriptional knockdowns, we generated a panel of metabolically compromised strains to identify tolera...
The Omp85 family protein, TamA, exhibits characteristics of a suitable drug target against Pseudomonas aeruginosa [0.03%]
Om85家族蛋白TamA对铜绿假单胞菌具有合适的药物作用靶点特征
Rachael Duodu,David J Boocock,Lesley Hoyles et al.
Rachael Duodu et al.
The outer membrane (OM) of Gram-negative bacteria is crucial for cell stability and virulence and acts as a permeability barrier. The biogenesis, assembly and regulation of proteins in the OM are, therefore, attractive areas of study that c...
The accessory role of the outer membrane porin protein MspD in Mycobacterium smegmatis zinc homeostasis [0.03%]
MmpL3合成酶MspD外膜蛋白在烟曲霉锌稳态中的辅助作用
Elke Goethe,Martina Ackermann,Larissa Bulmann et al.
Elke Goethe et al.
Zinc is the second most abundant transition metal in living cells and is involved in numerous biological processes. Regulation of Mycobacterium smegmatis (MSMEG) zinc homeostasis and zinc-specific importers ZnuABC and ZnuABC2 in the mycobac...