Oxalate-mediated detoxification and bioaccumulation of lead and cadmium in Escherichia coli K-12 MG1655 [0.03%]
草酸介导的大肠杆菌K-12 MG1655铅和镉的解毒及积累
Nnabueze Darlington Nnaji,Chukwudi U Anyanwu,Taghi Miri et al.
Nnabueze Darlington Nnaji et al.
Lead (Pb) and cadmium (Cd) remain among the most persistent and hazardous heavy-metal contaminants in industrial effluents, posing severe risks to ecosystems and human health due to their non-biodegradable nature and high toxicity. In respo...
Investigating the mobility and host range of mobile genetic elements harbouring antimicrobial resistance genes in enterococci [0.03%]
肠球菌中携带抗微生物药物耐药基因的可移动遗传元件的传播和宿主范围研究
Jee In Kim,Rahat Zaheer,Athanasios Zovoilis et al.
Jee In Kim et al.
In this study, the abundance and conjugation capacity of mobile genetic elements (MGEs) carrying resistance genes such as vanA, tet(M) and erm(B) were investigated to enhance our understanding of antimicrobial resistance (AMR) dissemination...
Commonly prescribed medicines antagonise anti-MRSA antibiotics and select for resistance [0.03%]
常用药物会对抗抗MRSA抗生素并选择耐药性
Zoha Sohail,Henry A Claireaux,Andrew M Edwards et al.
Zoha Sohail et al.
Many commonly prescribed non-antibiotic medicines have off-target antimicrobial activity, yet their impact on antibiotic efficacy remains poorly understood. In this study, we investigated eight widely used UK prescription medicines and iden...
Christopher Zhang,Brian K Hammer
Christopher Zhang
Disruption of efflux activity reduces biofilm formation through multiple pathways [0.03%]
外排活性被干扰后通过多条途径减少生物膜的形成
Emma R Holden,Leanne Sims,Katie Orchard et al.
Emma R Holden et al.
Free-swimming bacteria must undergo large-scale changes in gene expression to form structured, aggregated biofilm communities. These regulatory changes are susceptible to environmental stimuli such as exposure to antimicrobials, which can a...
Copper-driven mutualism of Candida albicans and Staphylococcus aureus interkingdom biofilms [0.03%]
铜驱动的白色念珠菌和金黄色葡萄球菌互惠种间生物膜互动
Iana Kalinina,Roberto Vazquez-Muñoz,Orlando Ross et al.
Iana Kalinina et al.
Although fungi and bacteria commonly co-exist within polymicrobial communities, the molecular mechanisms underlying their interactions are still not well understood. Here, we show that the fungus Candida albicans forms biofilms with the bac...
Israel Canela-Pérez,Odila Saucedo-Cárdenas,Rodolfo Gamaliel Avila-Bonilla et al.
Israel Canela-Pérez et al.
Discontinuity in eukaryotic genes has been one of the most fascinating discoveries in molecular biology, involving small nuclear RNAs (snRNAs) to remove the intervening non-coding sequences from precursor mRNA transcripts. They assemble wit...
Genetic and functional characterization of the natural transformation system in Streptococcus constellatus [0.03%]
链球菌属星座链球菌天然转化系统的基因组及功能特征分析
Andreas Solberg Sagen,Kazi Shefaul Mulk Shawrob,Gabriela Salvadori et al.
Andreas Solberg Sagen et al.
Streptococcus constellatus is an opportunistic pathogen frequently associated with abscess formation in various body sites. While the species has been shown to acquire exogenous DNA through natural transformation, functional analyses of its...
Nutrient utilization and degradative enzyme activity of the dragon fruit canker pathogen, Neoscytalidium dimidiatum [0.03%]
龙果腐烂病原菌Neoscytalidium dimidiatum的营养利用和降解酶活性
Rachel E Kalicharan,Romina Gazis,Jessie Fernandez
Rachel E Kalicharan
Dragon fruit canker (DFC), caused by Neoscytalidium dimidiatum, is a major disease affecting dragon fruit production. However, the pathogen's nutrient utilization strategies and enzymatic activities remain poorly characterized. Using calcof...
Clinical Rel mutations that increase basal (p)ppGpp promote conjugal transfer of staphylococcal resistance plasmids [0.03%]
临床Rel变体可增加基线(p)ppGpp并促进金黄色葡萄球菌耐药质粒的接合转移
Ashley T Deventer,Ava Sutherland,Daria Biernacka et al.
Ashley T Deventer et al.
Conjugative transfer of plasmids represents a major route through which antibiotic resistance genes are spread. In the case of the prevalent and deadly pathogen Staphylococcus aureus, more than 90% of clinical isolates carry at least one pl...