Identification of marine methylotrophic bacteria cultured from cold-water coral reefs [0.03%]
冷水中珊瑚礁培养的甲基营养菌的鉴定
Sigmund Jensen,Marc G Dumont,David G Bourne
Sigmund Jensen
Cold-water coral reefs host diverse microbial communities that play key roles in nutrient cycling and deep-sea productivity. Among them, methylotrophic bacteria metabolize and cycle one-carbon (C1) compounds such as methane, methanol, methy...
Miguel Cámara,George P C Salmond,Paul Williams
Miguel Cámara
Bacteria exhibit sophisticated forms of multicellularity by coordinating the activities of individual cells with respect to behaviours such as symbiosis, conjugation, competence, swarming, secondary metabolite production, biofilm formation,...
Altered distribution of chronicity-deficient Pseudomonas aeruginosa mutant guides optimization of synthetic chronic wound model [0.03%]
慢性缺陷型铜绿假单胞菌突变体分布的改变指导合成性慢性伤口模型的优化
Bethan Roberts,Claire S Laxton,Daniella L Spencer et al.
Bethan Roberts et al.
Pseudomonas aeruginosa is commonly isolated from chronic wounds where it forms biofilms that are recalcitrant to current treatments, greatly impacting the morbidity and mortality of infected patients. Since P. aeruginosa dictates wound seve...
Aspergillus fumigatus coinfection facilitates Pseudomonas aeruginosa chronicity within an ex-vivo pig lung model [0.03%]
烟曲霉感染促进铜绿假单胞菌在体外猪肺模型中慢性化的研究
Aaron Curtis,David A Fitzpatrick,Freya Harrison et al.
Aaron Curtis et al.
Pseudomonas aeruginosa and Aspergillus fumigatus represent the dominant bacterial and fungal pathogens in the lungs of adults with cystic fibrosis. Understanding how these species interact with each other and the host may provide insight in...
Microbe Profile: Vibrio pectenicida: the deadly marine bacteria with strains impacting sea stars and scallops [0.03%]
模式微生物：副溶血性弧菌pectenicida亚种及其对海洋生物的影响
Paradyse E Blackwood,Kayla C King,Amy M Chan et al.
Paradyse E Blackwood et al.
Vibrio pectenicida is a marine Gram-negative, facultatively anaerobic, rod-shaped bacterium that exists in coastal waters. First described in 1998, these bacteria are associated with deadly disease outbreaks including sea star wasting disea...
Future-ready antimicrobials: harnessing organic acids to override Ca2+-driven barrier failure during Salmonella infection [0.03%]
未来抗菌剂：利用有机酸在沙门氏菌感染期间克服Ca2+引起的屏障功能障碍
Igori Balta,Ioan Pet,Nicolae Corcionivoschi et al.
Igori Balta et al.
Organic acid mixtures are widely employed as feed additives to suppress enteric pathogens, yet their mechanisms of host protection at the intestinal epithelium remain unclear. Salmonella Typhimurium is a major cause of foodborne illness and...
Diverse unsaturated fatty acids bypass loss of FabH-catalysed initiation of fatty acid synthesis in Enterococcus faecalis [0.03%]
芽孢链球菌中脂肪酸合成起始步骤的旁路机制研究
Qi Zou,Huijuan Dong,John E Cronan
Qi Zou
The initiation reaction of fatty acid synthesis in Enterococcus faecalis is catalysed by the FabH 3-ketoacyl-acyl carrier protein (ACP) synthase III. Deletion of the fabH gene seriously impaired growth but failed to fully block de novo fatt...
Clinical isolates of Fusobacterium nucleatum display strain-specific virulence and modulation by indole derivatives [0.03%]
临床分离的福氏拟杆菌菌株特异性毒力及其通过吲哚衍生物进行调节
Colin Scano,Ankan Choudhury,Macarena G Rojo et al.
Colin Scano et al.
Pathogenic bacteria adapt to distinct disease environments, but whether these adaptations create therapeutic vulnerabilities remains unclear. Fusobacterium nucleatum has emerged as a key microbial player in colorectal cancer (CRC), yet its ...
Using auxotrophic donor strains to explore pQBR57 plasmid host range among environmental soil bacterial isolates [0.03%]
利用营养缺陷型供体菌株探索pQBR57质粒在环境土壤分离细菌间的宿主范围
Alejandro Marquiegui-Alvaro,Anastasia Kottara,Matthew J N Thomas et al.
Alejandro Marquiegui-Alvaro et al.
Plasmid host range (PHR) plays a key role in the spread of ecologically important genes, alongside applications in microbiome engineering and environmental biotechnology. PHR is a complex trait arising from the combination of plasmid, donor...
Methamphetamine promotes methicillin-resistant Staphylococcus aureus subcutaneous infection through innate immune dysregulation and altered expression of biofilm-associated genes [0.03%]
冰毒通过固有免疫失常和生物膜相关基因表达的改变促进耐甲氧西林金黄色葡萄球菌皮下感染
Renita Jewth,Yehia Elgammal,Hiu Ham Lee et al.
Renita Jewth et al.
Methamphetamine (METH) use is associated with an elevated risk of skin and soft tissue infections caused by methicillin-resistant Staphylococcus aureus (MRSA), yet its direct effects on MRSA pathogenesis remain poorly characterized. Using a...