Computing membrane-AQP5-phosphatidylserine binding affinities with hybrid steered molecular dynamics approach [0.03%]
采用混合驱动分子动力学方法计算膜-AQP5-磷脂酰丝氨酸结合亲和力
Liao Y Chen
Liao Y Chen
In order to elucidate how phosphatidylserine (PS6) interacts with AQP5 in a cell membrane, we developed a hybrid steered molecular dynamics (hSMD) method that involved: (1) Simultaneously steering two centers of mass of two selected segment...
Molecular mechanism of action of chlorogenic acid on erythrocyte and lipid membranes [0.03%]
氯原酸作用于红细胞膜和脂质膜的分子机制研究
Dorota Bonarska-Kujawa,Sylwia Cyboran-Mikołajczyk,Halina Kleszczyńska
Dorota Bonarska-Kujawa
The high antioxidant capacity of chlorogenic acid (CGA) in respect to biological systems is commonly known, though the molecular mechanism underlying that activity is not known. The aim of the study was to determine that mechanism at the mo...
Cardioprotective role of G-Protein Coupled Estrogen Receptor 1 (GPER1) [0.03%]
G蛋白偶联雌激素受体1(GPER1)的心脏保护作用
Sivaramakrishna Koganti
Sivaramakrishna Koganti
G-Protein Coupled Estrogen Receptor 1 (GPER1), also known as G-Protein Coupled Receptor 30 (GPR30) and initially considered an orphan receptor, has become one of the most important pharmacological targets in cardiovascular research. Since t...
Protein "amyloid-like" networks at the phospholipid membrane formed by 4-hydroxy-2-nonenal-modified mitochondrial creatine kinase [0.03%]
丙二醛修饰的线粒体肌酸激酶在磷脂膜上形成“淀粉样”的蛋白网络
Ofelia Maniti,Liberty François-Moutal,Marie-France Lecompte et al.
Ofelia Maniti et al.
4-Hydroxy-2-nonenal (4-HNE) is a reactive aldehyde and a lipid peroxidation product formed in biological tissues under physiological and pathological conditions. Its concentration increases with oxidative stress and induces deleterious modi...
Probing residues in the pore-forming (M2) domain of the Cys-loop receptor homologue GLIC reveals some unusual features [0.03%]
探究Cys-Loop受体同源物GLIC的孔形成(M2)结构域中的残基揭示了一些不同寻常的特点
Mona A Alqazzaz,Sarah C R Lummis
Mona A Alqazzaz
Cys-loop receptors play important roles in signal transduction. The Gloeobacter ligand-gated ion channel (GLIC) pore binds similar compounds to Cys-loop receptor pores, but has the advantage of known structures in open and closed states. GL...
Discreet and distinct clustering of five model membrane proteins revealed by single molecule localization microscopy [0.03%]
单分子定位显微镜揭示的五种模型膜蛋白的离散且明确的聚集现象
Astrid Magenau,Dylan M Owen,Yui Yamamoto et al.
Astrid Magenau et al.
Compartmentalization is a functionally important property of the plasma membrane, yet the underlying principles that organize membrane proteins into distinct domains are not well understood. Using single molecule localization microscopy, we...
Purification and interaction analyses of two human lysosomal vitamin B12 transporters: LMBD1 and ABCD4 [0.03%]
人类溶酶体维生素B12转运蛋白LMBD1和ABCD4的纯化及相互作用分析
Justin C Deme,Mark A Hancock,Xiaobing Xia et al.
Justin C Deme et al.
Mutations in human LMBRD1 and ABCD4 prevent lysosomal export of vitamin B(12) to the cytoplasm, impairing the vitamin B(12)-dependent enzymes methionine synthase and methylmalonyl-CoA mutase. The gene products of LMBRD1 and ABCD4 are implic...
Cholesterol modulates the interaction of the islet amyloid polypeptide with membranes [0.03%]
胆固醇调节胰岛淀粉样多肽与膜的相互作用
Lucie Caillon,Luminita Duma,Olivier Lequin et al.
Lucie Caillon et al.
The deposition of insoluble amyloid fibrils resulting from the aggregation of the human islet amyloid polypeptide (hIAPP) within the islet of Langerhans is a pathological feature of type 2 diabetes mellitus (T2DM). Increasing evidence indic...
Pyruvate dehydrogenase complex (PDC) export from the mitochondrial matrix [0.03%]
丙酮酸脱氢酶复合物(PDC)从线粒体基质中的释放
Fanny Ng,Bor Luen Tang
Fanny Ng
Studies on mitochondria protein import had revealed in detail molecular mechanisms of how peptides and proteins could be selectively targeted and translocated across membrane bound organelles. The opposite process of mitochondrial export, w...
The arginine-facing amino acid residue of the rat aquaporin 1 constriction determines solute selectivity according to its size and lipophilicity [0.03%]
大鼠Aquaporin1收缩环的精氨酸相氨基酸残基根据溶质大小及亲脂性决定通透性的高低
Dawid Krenc,Jie Song,Abdulnasser Almasalmeh et al.
Dawid Krenc et al.
Aquaporins (AQP) are transmembrane channels for small, predominantly uncharged solutes. Their selectivity is partly determined by the aromatic/arginine constriction. Ammonia is similar in size and polarity to water, yet a subset of aquapori...