Simon G Patching
Simon G Patching
Solid-state NMR is unique for its ability to obtain three-dimensional structures and to measure atomic-resolution structural and dynamic information for membrane proteins in native lipid bilayers. An increasing number and complexity of inte...
Differential dynamics of the serotonin1A receptor in membrane bilayers of varying cholesterol content revealed by all atom molecular dynamics simulation [0.03%]
基于全原子分子动力学模拟的膜双层中胆固醇含量不同的5-羟色胺受体动力学差异研究
Swarna M Patra,Sudip Chakraborty,Ganesh Shahane et al.
Swarna M Patra et al.
The serotonin1A receptor belongs to the superfamily of G protein-coupled receptors (GPCRs) and is a potential drug target in neuropsychiatric disorders. The receptor has been shown to require membrane cholesterol for its organization, dynam...
A unique SNARE machinery for exocytosis of cytotoxic granules and platelets granules [0.03%]
一种独特的SNARE机制介导细胞毒颗粒和血小板颗粒的胞外分泌过程
Bor Luen Tang
Bor Luen Tang
Cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells target infected or transformed cells with perforin-containing cytotoxic granules through immune synapses, while platelets secrete several types of granules which contents are esse...
Emerging roles of system [Formula: see text] antiporter and its inhibition in CNS disorders [0.03%]
系统[Sr公式]反向转运蛋白及其抑制在中枢神经系统疾病中所起的作用不容忽视
Dhaval Patel,Prashant S Kharkar,Mukesh Nandave
Dhaval Patel
System [Formula: see text] is an antiporter belonging to the hetero(di)meric amino acid transporter family. It is located on astrocytes as well as on blood-brain barrier within the CNS. It plays a pivotal role in free radical neutralization...
Sonic hedgehog multimerization: a self-organizing event driven by post-translational modifications? [0.03%]
sonic hedgehog多聚化：一种由翻译后修饰驱动的自组织事件？
Mirella V Koleva,Stephen Rothery,Martin Spitaler et al.
Mirella V Koleva et al.
Sonic hedgehog (Shh) is a morphogen active during vertebrate development and tissue homeostasis in adulthood. Dysregulation of the Shh signalling pathway is known to incite carcinogenesis. Due to the highly lipophilic nature of this protein...
Samuel Furse,Anton I P M de Kroon
Samuel Furse
Since its discovery in the 19th century, phosphatidylcholine (PC) has been regarded primarily as a structural lipid. However, more recent evidence, much of it in the last five years, strongly suggests that PC has other roles. Here, we explo...
Regulation of the Ca(2+)-ATPase by cholesterol: a specific or non-specific effect? [0.03%]
胆固醇对Ca(2+)-ATP酶的调节作用：一种特定的作用还是非特异性效应？
Henriette Elisabeth Autzen,Iwona Siuda,Yonathan Sonntag et al.
Henriette Elisabeth Autzen et al.
Like other integral membrane proteins, the activity of the Sarco/Endoplasmic Reticulum Ca(2+)-ATPase (SERCA) is regulated by the membrane environment. Cholesterol is present in the endoplasmic reticulum membrane at low levels, and it has th...
Samuel Furse,Maarten R Egmond,J Antoinette Killian
Samuel Furse
Isolation of the lipid fraction from biological samples has been a crucial part of countless studies over the last century. This considerable research interest has led to the development of a number of methods for isolating a range of molec...
Tony Magee,Peter Henderson,Alison Baker et al.
Tony Magee et al.
The multidrug resistance pump ABCB1 is a substrate for the ubiquitin ligase NEDD4-1 [0.03%]
多药耐药泵ABCB1是泛素连接酶NEDD4-1的底物
Begum G Akkaya,Joseph K Zolnerciks,Tasha K Ritchie et al.
Begum G Akkaya et al.
The ATP Binding Cassette transporter ABCB1 can export the neurotoxic peptide β-amyloid from endothelial cells that line the blood-brain barrier (BBB). This has the potential to lower cerebral levels of β-amyloid, but ABCB1 expression in t...