The multidrug resistance pump ABCB1 is a substrate for the ubiquitin ligase NEDD4-1
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The ATP Binding Cassette transporter ABCB1 can export the neurotoxic peptide β-amyloid from endothelial cells that line the blood-brain barrier (BBB). This has the potential to lower cerebral levels of β-amyloid, but ABCB1 expression in the BBB appears to be... ...
