Computational design and biophysical validation of macrocyclic peptides as inhibitors of SLIT2/ROBO1 interaction [0.03%]
计算设计及生物物理验证宏环肽作为SLIT2/ROBO1相互作用的抑制剂
Somaya A Abdel-Rahman,Maxence Delaunay,Tâp Ha-Duong et al.
Somaya A Abdel-Rahman et al.
The SLIT2/ROBO1 signaling axis regulates cellular migration and angiogenesis but also contributes to tumor progression and immune evasion in glioblastoma. Targeting this pathway with small molecules or antibodies remains challenging due to ...
Design, synthesis and evaluation of novel BRD4 and RIPK3 dual inhibitors as potential anti-inflammatory agents and antidotes for arsenicals [0.03%]
新型BRD4和RIPK3双重抑制剂的设计、合成及评价作为潜在的抗炎剂和砷类解毒剂
Omar Moukha-Chafiq,Marina Fosso Yatchang,Kaitlyn Houghtling et al.
Omar Moukha-Chafiq et al.
Arsenicals and other vesicant chemical weapons are highly reactive, toxic substances capable of causing severe and painful blistering and inflammation following topical exposure. These effects can also lead to a wide range of systemic organ...
Design, synthesis and biological evaluation of Chidamide derivatives against breast cancer [0.03%]
希美替尼衍生物的设计、合成及抗乳腺癌活性研究
Ying Zhou,Ziyan Lang,Haiyan Lin et al.
Ying Zhou et al.
In this study, we designed and synthesized a series of compounds derived from the histone deacetylase inhibitor (HDACi) Chidamide and the BET bromodomain inhibitor (+)-JQ-1. All target compounds were structurally characterized by 1H NMR, 13...
Optimizing clofibrate with eugenol contributes a novel hypolipidemic agent with minimal liver injury [0.03%]
肉桂醛优化克罗孚可降低脂质水平且几乎不损伤肝脏的新药剂研究
Xinyu Zhang,Xinyi Shi,Yumiao Song et al.
Xinyu Zhang et al.
It is well-established that clofibrate (CF)-induced hepatotoxicity involves oxidative stress and inflammatory responses. To address this issue, we employed a molecular hybridization strategy to optimize the CF structure, aiming to develop c...
Novel 2-aminopyrimidine carboxamide derivatives as potential anti-Alzheimer's disease agents: Design, synthesis, biological activity and computational simulation evaluation [0.03%]
新型2-氨基嘧啶羧酰胺衍生物作为潜在的抗阿尔茨海默病制剂：设计、合成、生物活性及计算模拟评价
Yi-Xuan Wang,Xue-Wei Zhou,Wen-Rong Du et al.
Yi-Xuan Wang et al.
In this study, a series of 2-amino-5-formamidopyrimidine derivatives were designed and synthesized. Their potential as cholinesterase inhibitors (ChEIs) for the treatment of Alzheimer's disease (AD) were evaluated by the Ellman method. Mean...
New benzyldiazepane derivatives able to reduce biofilm formation in Escherichia coli [0.03%]
新的苯基二氮卓烷衍生物能够减少大肠杆菌生物被膜的形成
Laura Braconi,Elena Perrin,Andrea Carlotta Conti et al.
Laura Braconi et al.
Antimicrobial resistance (AMR) represents a serious problem for human health and arises through several mechanisms. Bacteria can further enhance their intrinsic resistance by forming biofilms, defensive barriers that protect bacterial cells...
CYP1-bioactivated 2,4-diaryl-substituted pyridine analogues with remarkable activity in a breast cancer in vitro model [0.03%]
一种具有显著乳腺癌体外模型活性的二芳基取代吡啶类似物
Ketan Ruparelia,Dyan N Ankrett,Kenneth J M Beresford et al.
Ketan Ruparelia et al.
A series of 2,4-diaylpyridine analogues 8(1-9) was synthesised and evaluated for antiproliferative activity against a panel of human tumour and non-tumour breast cell lines that was characterised for CYP1 A1, A2 and B1 isoforms expression. ...
Imperfectly amphipathic design of α-helical antimicrobial peptides demonstrating potent antimicrobial activity with low toxicity [0.03%]
一种具有高效抗菌活性低毒性的两亲性不平衡型α-螺旋抗菌肽的设计
Zixuan Fan,Jieru Huang,Md Fahim Shahriar et al.
Zixuan Fan et al.
Antimicrobial peptides (AMPs) are regarded as the most promising candidates for next-generation antimicrobial agents, with amphipathicity serving as a critical factor in de novo design or systematic optimization. Previous studies rarely inv...
Design, synthesis and evaluation of NTM-006-derived analgesics with enhanced potency [0.03%]
具有增强效力的NTM-006衍生物镇痛剂的设计、合成及评估
Qinlan Mu,Hao Zhou,Quaowei Li et al.
Qinlan Mu et al.
Based on the structure of NTM-006, a selective adenosine A3 receptor (A3AR) agonist developed by Janssen Pharmaceutica NV, a series of novel analgesics was designed and synthesized. Their analgesic activity was evaluated using the acetic ac...
Design and synthesis of sorbicillinoid-derived bibenzyl and brominated analogues as anti-inflammatory agents [0.03%]
设计并合成具有抗炎活性的山梨酸衍生物bibenzyl和溴化类似物
Bei Zhang,Zhipeng Xu,Meng Zhang et al.
Bei Zhang et al.
Sorbicillinoids, a class of fungal metabolites, have shown promising anti-inflammatory activity. Considering the importance of the biphenyl pharmacophore in anti-inflammatory agents and the favorable role of halogenation in optimizing drug-...