Design, synthesis, and biological activity evaluation of Pyrimido[4,5-b]pyridine-based derivatives as SOS1 inhibitors [0.03%]
基于嘧啶并吡啶衍生物作为SOS1抑制剂的设计、合成及生物活性研究
Gangsheng Chen,Qin Ban,Zhengyang Wang et al.
Gangsheng Chen et al.
SOS1 represents a promising therapeutic target for pan-RAS inhibition. In this study, we designed and synthesized a series of pyrimido[4,5-b]pyridine derivatives using commercially available (R)-1-phenylethan-1-amine and pyrido[2,3-d]pyrimi...
Identification of non-hydroxamate histone deacetylase 8 inhibitors using deep learning-based screening of two-dimensional molecular images [0.03%]
基于深度学习的二维分子图像筛选非羟胺类组蛋白去乙酰酶8抑制剂识别方法
Yasunobu Yamashita,Juhyun Yun,Ayumu Asai et al.
Yasunobu Yamashita et al.
Histone deacetylase 8 (HDAC8) is a zinc-dependent enzyme that deacetylates proteins and is involved in cancer development, making its inhibition a potential anticancer strategy. Most reported HDAC8 inhibitors contain a hydroxamate zinc-bind...
Recent advances in dual-function fluorescent ligands targeting mitochondrial DNA G-Quadruplexes for Cancer Theranostics [0.03%]
靶向线粒体DNA G-四链体的双功能荧光配体在肿瘤诊疗中的最新进展
Ming-Hao Hu
Ming-Hao Hu
The identification of G-quadruplex (G4) structures in mitochondrial DNA (mtDNA) offers a promising avenue for targeted cancer therapy. Unlike nuclear DNA, mtDNA lacks histone protection and comprehensive repair mechanisms, making mitochondr...
Development of tacrine-based multitarget-directed ligands as dual AChE/EGFR inhibitors with neuroprotective activity [0.03%]
基于Tacrine的多靶点导向配体作为乙酰胆碱酯酶/表皮生长因子受体双重抑制剂的开发及其神经保护作用研究
Yuqing Wei,Ao Zhang,Weimin Qiu et al.
Yuqing Wei et al.
Alzheimer's disease (AD) is a multifaceted neurodegenerative disease for which current therapies primarily rely on cholinesterase inhibitors (ChEIs). Tacrine was the first and potent ChEI, which was soon withdrawn due to hepatic side effect...
Artificial intelligence-driven drug discovery: a new era in therapeutic innovation [0.03%]
人工智能驱动的药物发现：治疗创新的新时代
Qian Ya Swee,Shi Hui Law,Huang-Ju Tu et al.
Qian Ya Swee et al.
Artificial intelligence (AI) is a computer system that performs tasks that require learning, problem-solving and decision-making skills. It mimics humans' cognitive functions, which include pattern recognition. Vast amounts of data serve as...
New potential HIV-1 inhibitors, analogues to efavirenz, containing the isatin core [0.03%]
一类新的HIV-1抑制剂，含异丁酸内核的埃夫拉昔恩类似物
Gustavo P Machado,Pedro A G Costa,Debora I Leite et al.
Gustavo P Machado et al.
HIV/AIDS remains a major global health challenge, with millions of new infections reported annually. Among the available antiretroviral therapies, non-nucleoside reverse transcriptase inhibitors (NNRTIs) play a crucial role by targeting vir...
TPE-peptide@CaCO₃ targeting mitochondrial calcium overload and PDT synergistic tumor therapy [0.03%]
用于靶向线粒体钙超载和光动力治疗的TPE-肽@碳酸钙肿瘤协同疗法
Jinrong Chen,Peixuan Zhao,Jiaqi Li et al.
Jinrong Chen et al.
The high mortality rate of cancer necessitates the development of efficient treatments. Here, we developed acid-sensitive CaCO₃ (calcium carbonate) particles loaded with TPE (tetraphenylethylene)-peptide conjugates for mitochondrial target...
Compounds mimicking the Michaelis-Menten transition state of the phosphatidylinositol 4-kinase [0.03%]
模仿磷脂酰肌醇-4-激酶的迈克耳孙-mented过渡态的化合物
Hubert Hřebabecký,Martin Klima,Milan Dejmek et al.
Hubert Hřebabecký et al.
Phosphatidylinositol 4-kinases (PI4Ks) are crucial enzymes in lipid signaling responsible for generating phosphatidylinositol-4-phosphate (PI4P). Although the ATP-binding site of PI4Ks has been extensively studied, the structural characteri...
5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine-based thiosemicarbazones as anti-Trypanosoma cruzi agents [0.03%]
基于5,6,7,8-四氢咪唑并[1,2-α]吡嗪的噻二唑啉亚胺𬭩化合物作为抗克氏锥虫剂的研究
Marlene Saraiva de Araújo Neta,Maísa Cavalcanti Coelho,Felipe Neves Coutinho et al.
Marlene Saraiva de Araújo Neta et al.
Chagas disease, caused by Trypanosoma cruzi, remains a major neglected tropical disease for which current chemotherapies are limited by toxicity and variable efficacy. In the present work, a new series of 5,6,7,8-tetrahydroimidazo[1,2-a]pyr...
Recent developments in Haspin kinase inhibitors: Structure, synthesis and activities [0.03%]
Haspin激酶抑制剂的研究进展：结构、合成及活性
Killian Malosse,Elisabeth Pereira,Francis Giraud et al.
Killian Malosse et al.
Haspin is an atypical serine/threonine protein kinase involved in the regulation of mitosis progression. In the recent years, significant progress, especially in terms of selectivity, has been achieved in the discovery of Haspin inhibitors....