The fungivorous amoeba Protostelium aurantium targets redox homeostasis and cell wall integrity during intracellular killing of Candida parapsilosis [0.03%]
捕食真菌的变形虫Protostelium aurantium在Candida parapsilosis胞内致死过程中的氧化还原稳态及细胞壁完整性靶标研究
Silvia Radosa,Jakob L Sprague,Siu-Hin Lau et al.
Silvia Radosa et al.
Predatory interactions among microbes are major evolutionary driving forces for biodiversity. The fungivorous amoeba Protostelium aurantium has a wide fungal food spectrum including foremost pathogenic members of the genus Candida. Here we ...
Porphyromonas gingivalis induces penetration of lipopolysaccharide and peptidoglycan through the gingival epithelium via degradation of coxsackievirus and adenovirus receptor [0.03%]
牙龈卟啉单胞菌通过降解柯萨奇病毒和腺病毒受体诱导脂多糖和肽聚糖穿透牙龈上皮细胞
Hiroki Takeuchi,Shunsuke Yamaga,Naoko Sasaki et al.
Hiroki Takeuchi et al.
Porphyromonas gingivalis is a major pathogen of human periodontitis and dysregulates innate immunity at the gingival epithelial surface. We previously reported that the bacterium specifically degrades junctional adhesion molecule 1 (JAM1), ...
Che Julius Ngwa,Afia Farrukh,Gabriele Pradel
Che Julius Ngwa
Zinc finger proteins (ZFPs) are a large diverse family of proteins with one or more zinc finger domains in which zinc is important in stabilising the domain. ZFPs can interact with DNA, RNA, lipids or even other proteins and therefore contr...
Host manipulation by bacterial type III and type IV secretion system effector proteases [0.03%]
细菌III型和IV型分泌系统效应蛋白酶对宿主的操控作用
Flávia Viana,Shruthi Sachidanandan Peringathara,Arshad Rizvi et al.
Flávia Viana et al.
Proteases are powerful enzymes, which cleave peptide bonds, leading most of the time to irreversible fragmentation or degradation of their substrates. Therefore they control many critical cell fate decisions in eukaryotes. Bacterial pathoge...
Taiane N Souza,Alessandro F Valdez,Juliana Rizzo et al.
Taiane N Souza et al.
Lipid microdomains or lipid rafts are dynamic and tightly ordered regions of the plasma membrane. In mammalian cells, they are enriched in cholesterol, glycosphingolipids, Glycosylphosphatidylinositol-anchored and signalling-related protein...
Mucosal immune responses in the trachea after chronic infection with Mycoplasma gallisepticum in unvaccinated and vaccinated mature chickens [0.03%]
未接种和接种鸡感染鸡毒支原体后的气管黏膜免疫反应
Sathya N Kulappu Arachchige,Nadeeka K Wawegama,Mauricio J C Coppo et al.
Sathya N Kulappu Arachchige et al.
Tracheitis associated with the chronic respiratory disease in chickens caused by Mycoplasma gallisepticum is marked by infiltration of leukocytes into the mucosa. Although cytokines/chemokines are known to play a key role in the recruitment...
Feminising Wolbachia disrupt Armadillidium vulgare insulin-like signalling pathway [0.03%]
沃尔巴克体雌性化干扰臂尾仓鼠绝缘素信号通路
Benjamin Herran,Camille Houdelet,Maryline Raimond et al.
Benjamin Herran et al.
The endosymbiont Wolbachia feminises male isopods by making them refractory to the insulin-like masculinising hormone, which shunts the autocrine development of the androgenic glands. It was, therefore, proposed that Wolbachia silences the ...
Endocytosis of the CdtA subunit from the Haemophilus ducreyi cytolethal distending toxin [0.03%]
杜克雷嗜血杆菌细胞致死膨胀毒素CdtA亚基的内吞作用
G Robb Huhn rd,Naly Torres-Mangual,John Clore et al.
G Robb Huhn rd et al.
Many Gram-negative pathogens produce a cytolethal distending toxin (CDT) with two cell-binding subunits (CdtA + CdtC) and a catalytic CdtB subunit. After adhesion to the plasma membrane of a target cell, CDT moves by retrograde transport to...
Hepatitis E virus egress and beyond - the manifold roles of the viral ORF3 protein [0.03%]
hepatitis E病毒释放及更多：病毒ORF3蛋白的多重作用
Mirco Glitscher,Eberhard Hildt
Mirco Glitscher
Although the hepatitis E virus represents an uprising threat to the global community by representing the commonest cause of an acute viral hepatitis worldwide, its life cycle is grossly understudied. Albeit HEV is a non-enveloped virus, its...
Candidalysin delivery to the invasion pocket is critical for host epithelial damage induced by Candida albicans [0.03%]
candidalysin递送到入侵袋对于白念珠菌诱导的宿主上皮损伤至关重要
Selene Mogavero,Frank M Sauer,Sascha Brunke et al.
Selene Mogavero et al.
The human pathogenic fungus Candida albicans is a frequent cause of mucosal infections. Although the ability to transition from the yeast to the hypha morphology is essential for virulence, hypha formation and host cell invasion per se are ...