Malaria Cytoskeletal Proteins Require Alveolin-Alveolin Interactions for Differential Localization: Recruitment and Organization of Alveolin Proteins [0.03%]
疟原虫骨架蛋白通过Alveolin- Alveolin相互作用进行不同定位：Alveolin 蛋白的募集和组织
Ana Karla Cepeda Diaz,Peter S Back,Sreelakshmi K Sreenivasamurthy et al.
Ana Karla Cepeda Diaz et al.
The alveolins are a family of intermediate filament-like proteins that form cytoskeletal structures in both free-living and parasitic members of the alveolate kingdom. Despite their important functions, the alveolins' biochemical properties...
Vam6/Vps39/TRAP1-domain proteins influence vacuolar morphology, iron acquisition and virulence in Cryptococcus neoformans [0.03%]
Vam6/Vps39/TRAP1结构域蛋白影响新生隐球菌中的液泡形态，铁摄取和致病性
Guanggan Hu,Erik Bakkeren,Mélissa Caza et al.
Guanggan Hu et al.
The pathogenic fungus Cryptococcus neoformans must overcome iron limitation to cause disease in mammalian hosts. Previously, we reported a screen for insertion mutants with poor growth on haem as the sole iron source. In this study, we char...
Hepatitis B virus envelope proteins can serve as therapeutic targets embedded in the host cell plasma membrane [0.03%]
乙型肝炎病毒包膜蛋白可以作为嵌入宿主细胞质膜中的治疗靶点
Lili Zhao,Fuwang Chen,Oliver Quitt et al.
Lili Zhao et al.
Hepatitis B virus (HBV) infection is a major health threat causing 880,000 deaths each year. Available therapies control viral replication but do not cure HBV, leaving patients at risk to develop hepatocellular carcinoma. Here, we show that...
Chlamydia and HPV induce centrosome amplification in the host cell through additive mechanisms [0.03%]
衣原体和HPV通过累加机制诱导宿主细胞中心粒扩增
Kevin Wang,Karissa J Muñoz,Ming Tan et al.
Kevin Wang et al.
Based on epidemiology studies, Chlamydia trachomatis has been proposed as a co-factor for human papillomavirus (HPV) in the development of cervical cancer. These two intracellular pathogens have been independently reported to induce the pro...
Entry of the Varicellovirus Canid herpesvirus 1 into Madin-Darby canine kidney epithelial cells is pH-independent and occurs via a macropinocytosis-like mechanism but without increase in fluid uptake [0.03%]
犬疱疹病毒1型进入Madin-Darby犬肾上皮细胞的过程不依赖pH，且通过类似巨胞饮的方式进行，但没有增加液体摄取量
Mohamed Eisa,Hamza Loucif,Julien van Grevenynghe et al.
Mohamed Eisa et al.
Canid herpesvirus 1 (CHV-1) is a Varicellovirus that causes self-limiting infections in adult dogs but morbidity and mortality in puppies. Using a multipronged approach, we discovered the CHV-1 entry pathway into Madin-Darby canine kidney (...
Dengue virus replication enhances labile zinc pools by modulation of ZIP8 [0.03%]
登革热病毒复制通过调节ZIP8增强不稳定的锌池
Aleksha Panwar,Jigme Wangchuk,Meenakshi Kar et al.
Aleksha Panwar et al.
Zinc-dependent viral proteins rely on intracellular zinc homeostasis for successful completion of infectious life-cycle. Here, we report that the intracellular labile zinc levels were elevated at early stages of dengue virus (DENV) infectio...
Egress of archaeal viruses [0.03%]
古菌病毒的释放过程
Diana P Baquero,Junfeng Liu,David Prangishvili
Diana P Baquero
Viruses of Archaea, arguably the most mysterious part of the virosphere due to their unique morphotypes and genome contents, exploit diverse mechanisms for releasing virus progeny from the host cell. These include virus release as a result ...
Blockade of endoplasmic reticulum stress-induced cell death by Ureaplasma parvum vacuolating factor [0.03%]
人型支原体胞葬作用因子通过抑制内质网应激介导的细胞凋亡发挥抗炎作用
Fumiko Nishiumi,Yasuhiro Kawai,Yukiko Nakura et al.
Fumiko Nishiumi et al.
Previously, we found that Ureaplasma parvum internalised into HeLa cells and cytosolic accumulation of galectin-3. U. parvum induced the host cellular membrane damage and survived there. Here, we conducted vesicular trafficking inhibitory s...
BSC2 induces multidrug resistance via contributing to the formation of biofilm in Saccharomyces cerevisiae [0.03%]
BSC2通过促进假丝酵母菌生物膜的形成诱导多药耐药性
Zhiwei Huang,Hongsheng Dai,Xiaoyu Zhang et al.
Zhiwei Huang et al.
Biofilm plays an important role in fungal multidrug resistance (MDR). Our previous studies showed that BSC2 is involved in resistance to amphotericin B (AMB) through antioxidation in Saccharomyces cerevisiae. In this study, the overexpressi...
Rickettsia conorii survival in THP-1 macrophages involves host lipid droplet alterations and active rickettsial protein production [0.03%]
科尔尼立克次体在THP-1巨噬细胞中的存活涉及宿主脂滴的改变和立克次体活性蛋白的产生
Paige E Allen,Robert C Noland,Juan J Martinez
Paige E Allen
Rickettsia conorii is a Gram-negative, cytosolic intracellular bacterium that has classically been investigated in terms of endothelial cell infection. However, R. conorii and other human pathogenic Rickettsia species have evolved mechanism...