Advances in multifunctional metal-organic framework (MOF)-based nanoplatforms for cancer starvation therapy [0.03%]
多功能金属有机框架(MOF)纳米平台在癌症饥饿疗法中的进展
Jinghan Cai,Yan Xu,Fei Liao
Jinghan Cai
Cancer remains a significant threat to human health today. Even though starvation therapy and other treatment methods have recently advanced to a new level of rapid development in tumour treatment, their limited therapeutic effectiveness an...
Thrombocytopenia in dengue infection: mechanisms and a potential application [0.03%]
登革感染中的血小板减少症：机制和潜在应用
Ahmad Suhail Khazali,Waqiyuddin Hilmi Hadrawi,Fatimah Ibrahim et al.
Ahmad Suhail Khazali et al.
Thrombocytopenia is a common symptom and one of the warning signs of dengue virus (DENV) infection. Platelet depletion is critical as it may lead to other severe dengue symptoms. Understanding the molecular events of this condition during d...
Epitranscriptomics and cervical cancer: the emerging role of m6A, m5C and m1A RNA modifications [0.03%]
表观转录组学与宫颈癌：m6A、m5C和m1A RNA修饰的作用机制及研究进展
Akshat D Modi,Hira Zahid,Ashlyn Chase Southerland et al.
Akshat D Modi et al.
Cervical cancer (CC), one of the most prevalent and detrimental gynaecologic cancers, evolves through genetic and epigenetic alterations resulting in the promotion of oncogenic activity and dysfunction of tumour-suppressing mechanisms. Desp...
ADP-ribose hydrolases: biological functions and potential therapeutic targets [0.03%]
烟酰胺腺嘌呤二核苷酸（还原型）水解酶的生物学功能及其作为潜在治疗靶点的可能性
Jingpeng Wang,Zhao-Qi Wang,Wen Zong
Jingpeng Wang
ADP-ribosylation (ADPRylation), which encompasses poly(ADP-ribosyl)ation and mono(ADP-ribosyl)ation, is an important post-translational modification catalysed by the poly(ADP-ribose) polymerase (PARP) enzyme superfamily. The process involve...
Mechanism and application of immune interventions in intracerebral haemorrhage [0.03%]
免疫干预在脑出血中的机制及应用研究进展
Xiaoxiao Xu,Yuanwei Li,Shiling Chen et al.
Xiaoxiao Xu et al.
Despite stroke being one of the major and increasing burdens to global health, therapeutic interventions in intracerebral haemorrhage (ICH) continue to be a challenge. Existing treatment methods, such as surgery and conservative treatment h...
Advances in Raman spectroscopy for characterising oral cancer and oral potentially malignant disorders [0.03%]
拉曼光谱在口腔癌及癌前病变诊断中研究进展
Katie Hanna,Anna-Lena Asiedu,Thomas Theurer et al.
Katie Hanna et al.
Oral cancer survival rates have seen little improvement over the past few decades. This is mainly due to late detection and a lack of reliable markers to predict disease progression in oral potentially malignant disorders (OPMDs). There is ...
Understanding the autophagic functions in cancer stem cell maintenance and therapy resistance [0.03%]
癌干细胞维持和治疗抵抗的自噬功能研究进展
Niharika,Minal Garg
Niharika
Complex tumour ecosystem comprising tumour cells and its associated tumour microenvironment (TME) constantly influence the tumoural behaviour and ultimately impact therapy failure, disease progression, recurrence and poor overall survival o...
Repulsive guidance molecules b (RGMb): molecular mechanism, function and role in diseases [0.03%]
repellent导向分子b（RGMb）：分子机制、功能及其在疾病中的作用
Jie Zhang,Yijing Jiang,Zijian Zhang et al.
Jie Zhang et al.
Repulsive guidance molecule b (RGMb), a glycosylphosphatidylinositol-anchored member of the RGM family, is initially identified as a co-receptor of bone morphogenetic protein (BMP) in the nervous system. The expression of RGMb is transcript...
Epigenetic tuning of tumour-associated macrophages (TAMs): a potential approach in hepatocellular carcinoma (HCC) immunotherapy [0.03%]
表观遗传调控肿瘤相关巨噬细胞(TAMs)在肝癌免疫治疗中的应用潜力
Israa M Helal,Monica A Kamal,Mostafa K Abd El-Aziz et al.
Israa M Helal et al.
Recent development in immunotherapy for cancer treatment has substantiated to be more effective than most of the other treatments. Immunity is the first line of defence of the body; nevertheless, cancerous cells can manipulate immunity comp...
ATXN3: a multifunctional protein involved in the polyglutamine disease spinocerebellar ataxia type 3 [0.03%]
亨廷顿蛋白同系物3：与多聚谷氨酰胺疾病共济失调第三型有关的多功能蛋白质
Esperanza Hernández-Carralero,Grégoire Quinet,Raimundo Freire
Esperanza Hernández-Carralero
ATXN3 is a ubiquitin hydrolase (or deubiquitinase, DUB), product of the ATXN3 gene, ubiquitously expressed in various cell types including peripheral and neuronal tissues and involved in several cellular pathways. Importantly, the expansion...