Advances in Raman spectroscopy for characterising oral cancer and oral potentially malignant disorders [0.03%]
拉曼光谱在口腔癌及癌前病变诊断中研究进展
Katie Hanna,Anna-Lena Asiedu,Thomas Theurer et al.
Katie Hanna et al.
Oral cancer survival rates have seen little improvement over the past few decades. This is mainly due to late detection and a lack of reliable markers to predict disease progression in oral potentially malignant disorders (OPMDs). There is ...
Understanding the autophagic functions in cancer stem cell maintenance and therapy resistance [0.03%]
癌干细胞维持和治疗抵抗的自噬功能研究进展
Niharika,Minal Garg
Niharika
Complex tumour ecosystem comprising tumour cells and its associated tumour microenvironment (TME) constantly influence the tumoural behaviour and ultimately impact therapy failure, disease progression, recurrence and poor overall survival o...
Repulsive guidance molecules b (RGMb): molecular mechanism, function and role in diseases [0.03%]
repellent导向分子b（RGMb）：分子机制、功能及其在疾病中的作用
Jie Zhang,Yijing Jiang,Zijian Zhang et al.
Jie Zhang et al.
Repulsive guidance molecule b (RGMb), a glycosylphosphatidylinositol-anchored member of the RGM family, is initially identified as a co-receptor of bone morphogenetic protein (BMP) in the nervous system. The expression of RGMb is transcript...
Epigenetic tuning of tumour-associated macrophages (TAMs): a potential approach in hepatocellular carcinoma (HCC) immunotherapy [0.03%]
表观遗传调控肿瘤相关巨噬细胞(TAMs)在肝癌免疫治疗中的应用潜力
Israa M Helal,Monica A Kamal,Mostafa K Abd El-Aziz et al.
Israa M Helal et al.
Recent development in immunotherapy for cancer treatment has substantiated to be more effective than most of the other treatments. Immunity is the first line of defence of the body; nevertheless, cancerous cells can manipulate immunity comp...
ATXN3: a multifunctional protein involved in the polyglutamine disease spinocerebellar ataxia type 3 [0.03%]
亨廷顿蛋白同系物3：与多聚谷氨酰胺疾病共济失调第三型有关的多功能蛋白质
Esperanza Hernández-Carralero,Grégoire Quinet,Raimundo Freire
Esperanza Hernández-Carralero
ATXN3 is a ubiquitin hydrolase (or deubiquitinase, DUB), product of the ATXN3 gene, ubiquitously expressed in various cell types including peripheral and neuronal tissues and involved in several cellular pathways. Importantly, the expansion...
PARP enzymes and mono-ADP-ribosylation: advancing the connection from interferon-signalling to cancer biology [0.03%]
聚腺苷二磷酸核糖转移酶和单聚腺苷二磷酸核糖化反应：从干扰素信号转导到癌症生物学的连接研究进展
Barbara Morone,Giovanna Grimaldi
Barbara Morone
ADP-ribosyltransferases of the PARP family encompass a group of enzymes with variegated regulatory functions in cells, ranging from DNA damage repair to the control of cell-cycle progression and immune response. Over the years, this knowled...
Specific and shared biological functions of PARP2 - is PARP2 really a lil' brother of PARP1? [0.03%]
PARP2的特异及共通之生物学功能-PARP2真的是PARP1的小弟弟嗎？
Magdolna Szántó,José Yélamos,Péter Bai
Magdolna Szántó
PARP2, that belongs to the family of ADP-ribosyl transferase enzymes (ART), is a discovery of the millennium, as it was identified in 1999. Although PARP2 was described initially as a DNA repair factor, it is now evident that PARP2 partakes...
Decoding bioactive signals of the RNA secretome: the cell-free messenger RNA catalogue [0.03%]
解码RNA分泌组的生物活性信号：无细胞信使RNA文库
Rhys E De Sota,Stephen R Quake,John J Sninsky et al.
Rhys E De Sota et al.
Despite gene-expression profiling being one of the most common methods to evaluate molecular dysregulation in tissues, the utilization of cell-free messenger RNA (cf-mRNA) as a blood-based non-invasive biomarker analyte has been limited com...
The multifaceted functions of long non-coding RNA HOTAIR in neuropathologies and its potential as a prognostic marker and therapeutic biotarget [0.03%]
HOTAIR长非编码RNA在神经病理中的多面功能及其作为预后标志物和治疗生物靶点的潜力
Faraz Ahmad,Ravi Sudesh,Atheeq Toufeeq Ahmed et al.
Faraz Ahmad et al.
Long non-coding RNAs (lncRNAs) are progressively being perceived as prominent molecular agents controlling multiple aspects of neuronal (patho)physiology. Amongst these is the HOX transcript antisense intergenic RNA, often abbreviated as HO...
Baoqi Yang,Dan Ma,Xueqing Zhu et al.
Baoqi Yang et al.
Autoimmune diseases are pathological autoimmune reactions in the body caused by various factors, which can lead to tissue damage and organ dysfunction. They can be divided into organ-specific and systemic autoimmune diseases. These diseases...