The effects of transcranial direct current stimulation (tDCS) on subjective, autonomic and neuropsychological response in the 7.5% CO2 experimental model of anxiety [0.03%]
经颅直流电刺激(tDCS)对7.5%CO2实验模型焦虑的主观、自主和神经心理反应的影响
Joanna Astrid Miler,Daniel Meron,David S Baldwin et al.
Joanna Astrid Miler et al.
Background: Anxiety is characterized by hypervigilance, distractibility and selective processing of negative information. There is growing evidence that prefrontal function underlies biases in threat processing and attent...
Enhancement of memory network activity in schizophrenia patients by phosphodiesterase-4 (PDE4) inhibitor, roflumilast: A pilot study [0.03%]
一项小型研究：磷酸二酯酶-4（PDE4）抑制剂罗氟司特可增强精神分裂症患者的记忆网络活动
Klaudia Stanoch,Donni Ann Staley,Peter Hawkins et al.
Klaudia Stanoch et al.
Background: Cognitive impairments are prevalent in schizophrenia and are associated with functional outcomes, yet there are currently no approved treatments to address these deficits. Roflumilast, a phosphodiesterase 4 in...
Effects of ayahuasca on neuropsychological performance and social cognition: A systematic review [0.03%]
霍磨卡对神经心理表现和社会认知的影响：系统性综述
Caio César de Paula,Anna Beatriz Vicentini,Lorena Terene Lopes Guerra et al.
Caio César de Paula et al.
Background: Ayahuasca has aroused increasing interest due to its therapeutic effects. However, its effects on cognition are poorly understood. Hence, a systematic review evaluating the cognitive effects of ayahuasca was c...
Confronting mortality: A meta-analysis and systematic review of psychedelic experiences and death anxiety [0.03%]
直面死亡： psychedelics体验与死亡焦虑的元分析和系统综述
Alicia Cohorst,Petri J Kajonius
Alicia Cohorst
This meta-analysis and systematic review examined the effects of psychedelic substances on death anxiety, specifically evaluating whether psychedelic experiences are associated with statistically significant reductions in death anxiety. A s...
Precision dosing of clozapine: A physiologically based pharmacokinetic/pharmacodynamic model integrating genetic polymorphisms and clinical outcomes [0.03%]
基于生理的药代动力学/药效学模型指导氯氮平个体化用药
Archana Mishra,Anand Srinivasan,Rituparna Maiti et al.
Archana Mishra et al.
Background: The efficacy of clozapine in treatment-resistant schizophrenia is limited by significant pharmacokinetic variability due to genetic polymorphisms, drug interactions, and environmental factors, necessitating pe...
Methamphetamine conditioned place preference in adolescent mice: Interaction between sex and strain [0.03%]
青春期小鼠的冰毒条件位置偏爱：性别和品系之间的相互作用
Lewis Nunez Severino,Andre B Toussaint,Rachael M Langa et al.
Lewis Nunez Severino et al.
Background: Methamphetamine (METH) use is higher in adolescent women than adolescent men. While rodent studies support a sex difference in the reinforcing effects of METH, few have investigated sex differences in the unde...
A phase 2 uncontrolled, open-label study of intranasal BPL-003 (5-methoxy- N,N-dimethyltryptamine) in patients with treatment-resistant depression [0.03%]
一项有关鼻用BPL-003（5-甲氧基-N，N-二甲基色胺）治疗难治性抑郁症的2期开放标签无对照临床试验
Claire Roberts,Mathieu Seynaeve,Anna O Ermakova et al.
Claire Roberts et al.
Aims: To evaluate the safety and effect on clinical outcomes of depression of Beckley Psytech Ltd (BPL)-003, an intranasal formulation of 5-methoxy-N,N-dimethyltryptamine, in patients with moderate-to-severe major depress...
Prenatal THC exposure and binge-like alcohol drinking in early adolescence: From sex-specific drinking vulnerability to abnormal endocannabinoid-dopamine nexus in the nucleus accumbens [0.03%]
孕产期THC暴露及青少年早期饮酒：从性别特异的饮酒易感性到伏隔核内异常的内源大麻素-多巴胺相互作用
Valentina Castelli,Giuseppe Tringali,Martina Di Bartolomeo et al.
Valentina Castelli et al.
Background: Endocannabinoid (eCB) signalling is pivotal for brain programming, including the reward system neurodevelopment. Prenatal exposure to Δ9-tetrahydrocannabinol (THC), cannabis psychoactive component, can pertur...
Association of polygenic risk for cannabis use disorder with brain structure among youth with and without bipolar disorder [0.03%]
携带大麻使用障碍多基因风险的年轻人在患有双相情感障碍和未患双相情感障碍的群体中的脑结构特征研究
Alysha A Sultan,Clement C Zai,Kody G Kennedy et al.
Alysha A Sultan et al.
Background: Cannabis use disorder (CUD) is common in youth, with elevated rates among youth with bipolar disorder (BD). Cannabis use among youth is also associated with anomalous neurostructural phenotypes. While neurophy...
Mapping the acute effects of cannabis on multiple memory domains: A randomized, double-blind, placebo-controlled study [0.03%]
大麻对多个记忆领域急性影响的图谱研究：随机双盲对照试验
Carrie Cuttler,Ryan J McLaughlin
Carrie Cuttler
Background: One of the most robust acute effects of cannabis is impaired memory. Although memory is not a unitary construct, most cannabis research has focused on verbal memory. Less is known about its effects on more eco...