Biosynthesis of thiopeptide antibiotics and their pathway engineering [0.03%]
硫肽类抗生素的生物合成及其途径改造工程化研究进展
Qi Zhang,Wen Liu
Qi Zhang
Thiopeptide antibiotics, a growing class of highly modified polythiazolyl peptides, have long been known for their remarkable bioactivities and unusual modes of actions. Uncovering of the ribosomal origin of thiopeptides now sets the stage ...
2-Deoxystreptamine-containing aminoglycoside antibiotics: recent advances in the characterization and manipulation of their biosynthetic pathways [0.03%]
含2-脱氧链霉素类氨基糖苷抗生素：其生物合成途径表征及调控研究的新进展
Sung Ryeol Park,Je Won Park,Yeon Hee Ban et al.
Sung Ryeol Park et al.
The 2-deoxystreptamine-containing aminoglycosides, such as neomycin, kanamycin and gentamicin, are an important class of antibiotics. A detailed understanding of the complete biosynthetic pathway of aminoglycosides and their biosynthetic en...
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature [0.03%]
核糖体合成且翻译后修饰的肽类天然产物的研究概况和关于通用命名法的建议
Paul G Arnison,Mervyn J Bibb,Gabriele Bierbaum et al.
Paul G Arnison et al.
This review presents recommended nomenclature for the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs), a rapidly growing class of natural products. The current knowledge regarding the biosynthesis ...
Jorge A R Salvador,João F S Carvalho,Marco A C Neves et al.
Jorge A R Salvador et al.
Steroids, a widespread class of natural organic compounds occurring in animals, plants and fungi, have shown great therapeutic value for a broad array of pathologies. The present overview is focused on the anticancer activity of steroids, w...
Refaat B Hamed,J Ruben Gomez-Castellanos,Luc Henry et al.
Refaat B Hamed et al.
The β-lactam antibiotics and related β-lactamase inhibitors are amongst the most important small molecules in clinical use. Most, but not all, β-lactams including penicillins, cephalosporins, and clavulanic acid are produced via fermenta...
William Erb,Jieping Zhu
William Erb
The first members of the tiacumicin family of antibiotics, encompassing more than 40 compounds, were isolated in 1975. Structurally, the core aglycon is an 18-membered macrolactone having two conjugated diene units, one isolated double bond...
Christopher T Walsh,Timothy A Wencewicz
Christopher T Walsh
Riboflavin-based coenzymes, tightly bound to enzymes catalyzing substrate oxidations and reductions, enable an enormous range of chemical transformations in biosynthetic pathways. Flavoenzymes catalyze substrate oxidations involving amine a...
Ursane-type pentacyclic triterpenoids as useful platforms to discover anticancer drugs [0.03%]
乌桑烷型五环三萜作为抗癌药物发现的有用平台
Jorge A R Salvador,Vânia M Moreira,Bruno M F Gonçalves et al.
Jorge A R Salvador et al.
This review highlights the potential of natural and semisynthetic ursane-type triterpenoids as candidates for the design of multi-target bioactive compounds, with focus on their anticancer effects. A brief illustration of the biosynthesis, ...
The impact of the United Nations Convention on Biological Diversity on natural products research [0.03%]
《生物多样性公约》对天然产物研究的影响
Gordon M Cragg,Flora Katz,David J Newman et al.
Gordon M Cragg et al.
The discovery and development of novel, biologically active agents from natural sources, whether they be drugs, agrochemicals or other bioactive entities, involve a high level of interdisciplinary as well as international collaboration. Suc...
Natural stilbenoids: distribution in the plant kingdom and chemotaxonomic interest in Vitaceae [0.03%]
茋类化合物的植物化学分类学研究进展及展望
Céline Rivière,Alison D Pawlus,Jean-Michel Mérillon
Céline Rivière
Stilbenoids, a family of polyphenols known for the complexity of their structure and for their diverse biological activities, occur with a limited but heterogeneous distribution in the plant kingdom. The most prominent stilbene containing p...