Bacterial cytological profiling for mode-of-action discovery of natural product-derived antibiotics: progress, challenges, and future directions [0.03%]
细菌细胞谱分析在天然产物抗生素作用机制发现中的进展、挑战与未来方向
Poochit Nonejuie,Thanadon Samernate,Filosofia F T A Prasasti et al.
Poochit Nonejuie et al.
Covering: 2013 up to 2026The rapid escalation of antimicrobial resistance has outpaced the discovery of natural product (NP)-derived antibiotics, underscoring the need for new strategies to identify and characterize antibacterial agents. NP...
The complexity cliff in natural product discovery: why full automation remains elusive and the case for collaborative intelligence [0.03%]
天然产物发现中的复杂性难题：完全自动化为何难以实现以及协同智能的重要性案例分析
Ran Lin,Chengzeng Zhou,Rongzhen Wu et al.
Ran Lin et al.
Covering: 1992 to 2025Natural products contribute to roughly half of FDA-approved small-molecule drugs, yet their discovery has remained surprisingly resistant to the automation that has reshaped synthetic medicinal chemistry. In this revie...
Hot off the Press [0.03%]
最新消息
Robert A Hill,Andrew Sutherland
Robert A Hill
A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as neocucurin A from Neocucurbitaria unguis-hominis.
Oxygen-independent enzymatic dearomatization of homocyclic aromatic compounds [0.03%]
无氧条件下杂环芳香烃化合物的去芳构化反应
Tingyi Zhan,Juliane Breiltgens,Lena Appel et al.
Tingyi Zhan et al.
Covering: 1995 up to the end of 2025Homocyclic aromatic compounds (HAC) represent the second most abundant class of natural and anthropogenic products. Their biodegradation is central to the global carbon cycle and the bioremediation of aro...
Muhammad Syamsu Rizaludin,Jeroen S Dickschat,Jos M Raaijmakers et al.
Muhammad Syamsu Rizaludin et al.
Covering: up to 2026Volatile organic compounds (VOCs) are key mediators of long-distance communication in biological systems. While their roles in plant-insect interactions are well established, emerging evidence highlights their importance...
From botanical origins to modern laboratories: 50 year journey in protoberberine alkaloid total synthesis [0.03%]
从植物来源到现代实验室：异异长春花碱全合成的五十年历程
Weijian Li,Shuman Guan,Mingwei Li et al.
Weijian Li et al.
Covering: up to 2025Protoberberine alkaloids (PBs) and tetrahydroprotoberberine alkaloids (THPBs) exhibit diverse pharmacological activities, driving significant interest in their efficient synthesis. This review systematically categorizes ...
Natural products for benign prostatic hyperplasia (BPH): structure-activity relationships and pathway mechanisms [0.03%]
前列腺增生（BPH）的天然药物：结构活性关系和途径机制
Tae-Young Gil,Ye-Seul Kim,Dong-Sung Lee et al.
Tae-Young Gil et al.
Covering: 2012-2025Benign prostatic hyperplasia (BPH) is a prevalent age-related disorder characterized by non-malignant prostate enlargement and lower urinary tract symptoms, arising from the interplay of androgen dysregulation, chronic in...
Opines: origins, roles, structures with a nomenclature proposal, and syntheses [0.03%]
Opinion类化合物的起源、功能、结构及命名学与合成研究进展
Leon Otten,Patrick Pale
Leon Otten
Covering: 1927 to 2026.Although discovered almost a century ago, opines represent an ever-growing family of natural products, derived from a variety of organisms, including bacteria, fungi, plants, and marine invertebrates. Opines exhibit a...
Ortho-alkyl phenylalkenoyl natural products: structural diversity, bioactivities and biosynthesis [0.03%]
间位连接的芳基烯酰天然产物：结构多样性、生物活性及生物合成路径分析
Qianfei Huang,Xuxiang Chen,Shuhong Ma et al.
Qianfei Huang et al.
Covering: up to 2026.Ortho-alkyl phenylalkenoyl-containing natural products, including cinnamoyl-containing nonribosomal peptides (CCNPs) and ortho-alkyl phenylalkenoic acids (APAs), are structurally and biologically diverse bacterial metab...
Radical-mediated cross-linking enzymes in RiPP biosynthesis [0.03%]
在环肽生物合成中的交联酶 radicals.mediated.cross linking enzymes 在 RiPP 生物合成中
Jabal Rahmat Haedar,Ying Shi,Mit A Bhatt et al.
Jabal Rahmat Haedar et al.
Covering: January 2020 to February 2026Ribosomally synthesized and post-translationally modified peptides (RiPPs) continue to be a rich source of chemically diverse and bioactive peptide natural products. In recent years, rapid progress has...