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Unlocking marine treasures: isolation and mining strategies of natural products from sponge-associated bacteria [0.03%] 海绵相关细菌次级代谢产物的挖掘策略研究进展
Jeong-A Kim,Si-Sun Choi,Jae Kyu Lim et al. Jeong-A Kim et al.
Covering: 2019 to early 2025Marine sponges form unique ecosystems through symbiosis with diverse microbial communities, producing natural products including bioactive compounds. This review comprehensively addresses the key steps in the dis...
Recent advances in the chemistry and biology of plant oxylipin hormones [0.03%] 植物氧脂素激素的化学及生物学最新研究进展
Yuho Nishizato,Taichi Okumura,Kotaro Matsumoto et al. Yuho Nishizato et al.
Jasmonates, including jasmonic acid (JA) and its derivatives, are lipid-based signaling molecules critical for plant growth, development, and defense. Among these, jasmonoyl-L-isoleucine (JA-Ile) has been identified as a bioactive plant hor...
Configurational assignments of type-I polyketide synthase (PKS)-derived natural products based on spectroscopic and chemical analysis: methodologies and case studies [0.03%] 基于光谱和化学分析的I型聚酮合酶（PKS）衍生天然产物构型测定：方法学与案例研究
Jinsheng Cui,Prima F Hillman,Geum Jin Kim et al. Jinsheng Cui et al.
Covering: 1992 to 2024Type-I polyketide synthase (PKS)-derived metabolites are structurally diverse bioactive natural products containing multiple stereogenic centres. This review focuses on the configurational analysis of type-I PKS-derive...
Unpacking policy developments in marine natural product research: a scientist's guide to DSI and BBNJ [0.03%] 解读海洋天然产物研究的政策发展：科学家的DSI和BBNJ指南
Federica Casolari,Amelia Westmoreland,Thomas Vanagt et al. Federica Casolari et al.
Covering: 2014 up to February 2025Since the Nagoya Protocol came into force in 2014, scientists working with genetic resources have integrated compliance with Access and Benefit-Sharing (ABS) legislation at international and national levels...
Synthetic biology strategies for cyanobacterial systems to heterologously produce cyanobacterial natural products [0.03%] 合成生物学策略在蓝细菌系统中异源生产蓝细菌天然产物
Manyun Chen,Dipesh Dhakal,Campbell W Eckhardt et al. Manyun Chen et al.
Covering: 2014 to 2024Cyanobacteria are prolific producers of bioactive natural products, including promising drug leads for FDA-approved cancer therapeutics. Advances in genome sequencing and computational tools have revealed a wealth of c...
Modulators of the ubiquitin-proteasome system from natural products: chemical structures and their potential for drug discovery [0.03%] 来源于天然产物的泛素-蛋白酶体系统调节剂：化学结构及药物发现潜力
Yuki Hitora,Sachiko Tsukamoto Yuki Hitora
Covering: up to 2024The ubiquitin-proteasome system (UPS) plays a key role in regulating intracellular protein degradation and maintaining cellular homeostasis. Within the UPS, target proteins are polyubiquitinated through sequential reacti...
The bisintercalator family of nonribosomal peptides: structural diversity and biosynthetic mechanism [0.03%] 双嵌入肽非核糖体多肽家族：结构多样性与生物合成机制
Xinjie Shi Xinjie Shi
Covering: up to February 2025Among the numerous bioactive microbial natural products, a subset of nonribosomal peptides derived from actinobacteria is characterized by their C2-symmetric macrocyclic scaffolds and referred to as bisintercala...
Hot off the Press [0.03%] 最新消息
Robert A Hill,Andrew Sutherland Robert A Hill
A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as melichuniione A from Melicope chunii.
Molecular insights fast-tracked: AI in biosynthetic pathway research [0.03%] 分子见解迅速揭晓：人工智能在生物合成途径研究中的应用
Lijuan Liao,Mengjun Xie,Xiaoshan Zheng et al. Lijuan Liao et al.
Covering: 2000 to 2025This review explores the potential of artificial intelligence (AI) in addressing challenges and accelerating molecular insights in biosynthetic pathway research, which is crucial for developing bioactive natural produc...