From gene discovery to synthetic biology: recent advances in the biosynthesis of oleanane-type pentacyclic triterpenoids [0.03%]
从基因发现到合成生物学：齐墩果烷型五环三萜生物合成的最新进展
Ismail Abdelsamad,Mohamed Abdulbagi,Jingya Wang et al.
Ismail Abdelsamad et al.
Covering: 2010 to January 2026Oleanane-type pentacyclic triterpenoids (OPTs) represent a prominent class of plant-derived natural products, widely recognized for their potent pharmacological properties, including anticancer, anti-inflammato...
Koh Sakano,Kairi Furui,Apakorn Kengkanna et al.
Koh Sakano et al.
Covering: up to 2026Natural products are an important source of medicines, yet their discovery can be a slow and laborious process. The recent development of chemical language models (CLMs), which process string-based molecular representati...
Recent advances in decoding biosynthetic pathways and synthetic biology approaches for plant alkaloids [0.03%]
植物生物碱的生物合成途径的解码及合成生物学研究最新进展
Lanyu Zhou,Haiyue Gong,Huan Zhao et al.
Lanyu Zhou et al.
Covering: 2018 to 2025Alkaloids represent a large and structurally diverse class of natural products predominantly found in plants and rarely in animals. Well-known compounds such as vinblastine, berberine, and scopolamine exhibit remarkabl...
Structural determination of natural products at speeds and scale of high-throughput screening [0.03%]
以高通量筛选的速度和规模确定天然产物的结构
Christopher C Thornburg,Rohitesh Kumar,Dongdong Wang et al.
Christopher C Thornburg et al.
Covering 2000 up to 2025.This review assesses analytical techniques available for routine structural elucidation of small molecules as part of high-throughput screening campaigns of natural product libraries. The emphasis is on the speed an...
Skeleton innovation versus structural diversification in terpenoid discovery: chemoinformatic insights from TeroKit [0.03%]
萜类发现中的骨架创新与结构多样化：来自TeroKit的化学信息学见解
Tao Zeng,Jiahao Li,Ruibo Wu
Tao Zeng
Covering: up to the end of 2025Terpenoids, as one of the largest classes of natural products, derive their vast structural diversity from a combination of complex cyclic skeletons and extensive post-modifications. Although new terpenoids co...
High-throughput assays for SAM-dependent methyltransferases: advances, challenges, and future perspectives [0.03%]
S-腺苷甲硫氨酸依赖的甲基转移酶的高通量筛选：进展、挑战与未来展望
Renia Fotiadou,Florian Heinz,Konstantin F G Weigmann et al.
Renia Fotiadou et al.
Covering: up to January 2026Methyltransferases (EC 2.1.1.-) represent one of the most functionally diverse enzyme families in biology. Found across all domains of life-including bacteria, archaea, eukaryotes, and viruses-these enzymes catal...
Advancing natural product R&D&I: guide for compliance with responsible research and innovation, ethics, Nagoya and Cartagena Protocols, and intellectual property protection [0.03%]
天然产物研究开发和创新的推进：遵守责任科研与创新、伦理规范、《名古屋协议》及《卡塔赫纳协议》和知识产权保护指南
Susana P Gaudêncio,Belma Kalamujić Stroil,Lucie Novoveska et al.
Susana P Gaudêncio et al.
Covering: January 2005 to July 2025The interplay between Responsible Research and Innovation, the Nagoya and Cartagena Protocols and other legislative frameworks, ethical practices, and intellectual property protection plays a pivotal role ...
β-Lactam antibiotics and β-lactamases: historical perspectives and a review of β-lactamase inhibitors derived from natural products [0.03%]
头孢菌素和头孢菌酶：历史回顾及天然产物来源的头孢菌酶抑制剂研究进展
Phanankosi Moyo,Ikhane O Albert,Neo Hlungwani et al.
Phanankosi Moyo et al.
Covering: up to the end of November 2025The history of β-lactam antibiotics and, subsequently, β-lactamase inhibitors highlight the indispensable role of natural products in modern medicine. The isolation and testing of β-lactam bearing ...
A comprehensive review of the structural diversity, biosynthesis and chemical synthesis of Lasiodiplodia spp. natural products [0.03%]
端壳囊孢菌种茋类茋类茋类茋化合物的结构多样性、生物合成和化学合成研究进展
Maria Michela Salvatore,Marco Masi,Marina DellaGreca et al.
Maria Michela Salvatore et al.
Covering: up to the end of 2025The genus Lasiodiplodia belongs to the Botryosphaeriaceae family. Over the past few decades, it has proven to be a great source of interesting natural products, including depsidones, jasmonates, preussomerins,...
Bichu Cheng
Bichu Cheng
Covering: 2011 to 2026Furans with different substitution patterns can be found in various bioactive natural products. Developing new chemical reactions and catalytic systems for the controlled and selective synthesis of polysubstituted fura...