Is enzyme immobilization a mature discipline? Some critical considerations to capitalize on the benefits of immobilization [0.03%]
酶固定化是一个成熟的学科吗？充分利用固定化优势的一些关键考虑因素
Juan M Bolivar,John M Woodley,Roberto Fernandez-Lafuente
Juan M Bolivar
Enzyme immobilization has been developing since the 1960s and although many industrial biocatalytic processes use the technology to improve enzyme performance, still today we are far from full exploitation of the field. One clear reason is ...
Correction: Post-synthetic modifications in porous organic polymers for biomedical and related applications [0.03%]
关于纠正：多孔有机聚合物在生物医学及相关应用中的亚胺还原问题
Ji Hyeon Kim,Dong Won Kang,Hongryeol Yun et al.
Ji Hyeon Kim et al.
Correction for 'Post-synthetic modifications in porous organic polymers for biomedical and related applications' by Ji Hyeon Kim et al., Chem. Soc. Rev., 2022, 51, 43-56, https://doi.org/10.1039/D1CS00804H.
Published Erratum
Chemical Society reviews. 2022 Aug 1;51(15):6864. DOI:10.1039/d2cs90059a 2022
C-H bond activation and sequential addition to two different coupling partners: a versatile approach to molecular complexity [0.03%]
活化C-H键并顺序加成到两个不同的偶联伙伴上：构造分子多样性的简易方法
Daniel S Brandes,Jonathan A Ellman
Daniel S Brandes
Sequential multicomponent C-H bond addition is a powerful approach for the rapid, modular generation of molecular complexity in a single reaction. In this approach, C-H bonds are typically added across π-bonds or π-bond isosteres, followe...
Artificial photosynthesis systems for solar energy conversion and storage: platforms and their realities [0.03%]
人工光合作用系统在太阳能转换和存储中的应用：平台及其现状
Zhenfu Wang,Yang Hu,Songping Zhang et al.
Zhenfu Wang et al.
In natural photosynthesis, photosynthetic organisms such as green plants realize efficient solar energy conversion and storage by integrating photosynthetic components on the thylakoid membrane of chloroplasts. Inspired by natural photosynt...
Xuancan Zhu,Wenwen Xie,Junye Wu et al.
Xuancan Zhu et al.
Significant progress has been made in direct air capture (DAC) in recent years. Evidence suggests that the large-scale deployment of DAC by adsorption would be technically feasible for gigatons of CO2 capture annually. However, great effort...
Discovery of CRBN as a target of thalidomide: a breakthrough for progress in the development of protein degraders [0.03%]
CRBN成为thalidomide的作用靶点的发现：促进蛋白降解剂研发进展的重要突破
Junichi Yamamoto,Takumi Ito,Yuki Yamaguchi et al.
Junichi Yamamoto et al.
Progress in strategies aimed at breaking down therapeutic target proteins has led to a paradigm shift in drug discovery. Thalidomide and its derivatives are the only protein degraders currently used in clinical practice. Our understanding o...
Farzad Seidi,Yajie Zhong,Huining Xiao et al.
Farzad Seidi et al.
Prodrugs are developed to increase the therapeutic properties of drugs and reduce their side effects. Polyprodrugs emerged as highly efficient prodrugs produced by the polymerization of one or several drug monomers. Polyprodrugs can be grad...
The importance of cellular degradation kinetics for understanding mechanisms in targeted protein degradation [0.03%]
细胞降解动力学在理解靶向蛋白质降解机制中的重要性
Kristin M Riching,Elizabeth A Caine,Marjeta Urh et al.
Kristin M Riching et al.
Targeted protein degradation has exploded over the past several years due to preclinical and early clinical therapeutic success of numerous compounds, and the emergence of new degradation modalities, which has broadened the definition of wh...
Guo-Qing Jin,Calvin V Chau,Jonathan F Arambula et al.
Guo-Qing Jin et al.
In recent years, lanthanide (Ln) porphyrinoids have received increasing attention as theranostics. Broadly speaking, the term 'theranostics' refers to agents designed to allow both disease diagnosis and therapeutic intervention. This Review...
Layered double hydroxide-based nanomaterials for biomedical applications [0.03%]
基于层状双氢氧化物的纳米材料的生物医学应用研究进展
Tingting Hu,Zi Gu,Gareth R Williams et al.
Tingting Hu et al.
Against the backdrop of increased public health awareness, inorganic nanomaterials have been widely explored as promising nanoagents for various kinds of biomedical applications. Layered double hydroxides (LDHs), with versatile physicochemi...