J O Lannot,E L Rey,M D Gamarra et al.
J O Lannot et al.
Accurate prediction of structure of protein-carbohydrate complexes remains a significant challenge in structural glycobiology, largely due to the flexibility of glycans and the shallow, hydrophilic nature of their binding sites. To address ...
Efficient mucin O-glycan degradation by specific mucin degrading intestinal bacteria: towards understanding enzyme-glycan interactions [0.03%]
高效粘蛋白降解肠道细菌的O-糖链降解机制：迈向理解酶-糖基化多肽相互作用
Carol de Ram,Maryse D Berkhout,Marta Koziol et al.
Carol de Ram et al.
Intestinal mucin glycan-degrading bacteria are important for mucus turnover, stimulating mucus production, and producing beneficial metabolites. The mucin-degrading bacteria require various enzymes to break down mucin O-glycans. In this stu...
Functional inactivation of oligosaccharyltransferase A isoform suppresses tumor metastasis [0.03%]
寡糖转移酶A的功能失活可抑制肿瘤转移
Yang Shi,Yu Mizote,Akinobu Honda et al.
Yang Shi et al.
Oligosaccharyltransferase (OST), which is a multi-membrane protein complex that catalyzes asparagine-linked glycosylation (N-glycosylation) in the endoplasmic reticulum (ER), is a potential target to eradicate refractory cancer. Mammals exp...
Structural Analysis of Neutral Glycosphingolipids Bearing Human Blood Group-Like Sugar Units from the Mantle Skin of the Jumbo Flying Squid (Dosidicus gigas) [0.03%]
巨乌贼外套膜皮肤中携带人类血型类似糖单位的中性神经酰胺糖脂的结构分析
Saki Itonori,Yuri Akita,Taka Harahata et al.
Saki Itonori et al.
Glycosphingolipids (GSLs) from invertebrates often exhibit unique sugar chain structures distinct from those in vertebrates, reflecting evolutionary diversity in glycan biosynthesis. In this study, neutral GSLs were extracted and purified f...
High glucose enhances lung cancer cell aggressiveness: The impacts of GLUT1, UAP1, UGP2, and N-linked Glycosylation [0.03%]
高糖通过葡萄糖转运蛋白1(GLUT1)、尿苷二磷酸糖基转移酶2 UDP葡萄糖醛酸转移酶家族多肽2(UGP2)、N-连接聚糖重塑促进肺癌细胞恶性行为增强
Chatchai Phoomak,Charupong Saengboonmee,Marta Baro et al.
Chatchai Phoomak et al.
Lung cancer remains the leading cause of cancer-related deaths globally, underscoring the need for novel therapeutic strategies. The relationship between high glucose levels, N-linked glycosylation, and cancer progression has been observed ...
Dynamic tracking of GD3 to GD2 Gangliosides in T lymphoblasts via Nuclear Magnetic Resonance Spectroscopy [0.03%]
核磁共振技术在T淋巴母细胞中GD3和GD2神经节苷脂动态追踪中的应用研究
Roberta Salinas-Marín,Selena Rendón-García,Brenda I Velázquez-Dodge et al.
Roberta Salinas-Marín et al.
Gangliosides GD3 and GD2 are glycosphingolipids involved in key cellular processes and are overexpressed in various cancers, including T-cells leukemias. In this study, we investigated the temporal conversion of GD3 to GD2 in the human T ly...
Activity of α1,6-fucosyltransferase (FUT8) is reduced by depletion of oligosaccharyltransferase subunits [0.03%]
寡糖基转移酶亚单位的耗竭可降低α1,6-岩藻糖基转移酶(FUT8)的活性
Seita Tomida,Takahiro Yamasaki,Daisuke Kohda et al.
Seita Tomida et al.
Alpha-1,6-fucosyltransferase (FUT8) transfers fucose to the innermost GlcNAc residue of N-glycans, forming the core fucose structure. Core fucose critically regulates the functions of various glycoproteins and is associated with several dis...
Dysregulation of glycosaminoglycans during oocyte maturation in vitro: Implications for developmental potential [0.03%]
体外成熟卵母细胞糖胺聚糖的调控异常及其对发育潜能的影响
Darren J X Chow,Edward S X Moh,Laura N Watson et al.
Darren J X Chow et al.
A complex extracellular matrix (ECM) assembles around the mammalian oocyte during maturation and ovulation, comprising hyaluronan as well as proteoglycans. These proteoglycans are hypothesised to carry heparan and chondroitin sulfate side c...
Detection of Cardiac O-GlcNAcylation via Subcellular Fractionation and Dual Antibody Analysis in Pressure Overload Cardiac Hypertrophy [0.03%]
压力超负荷诱导的心肌肥大组织中O-GlcNAc酰化的亚细胞定位分析
Dolena Ledee,Wei Zhong Zhu,Aaron K Olson
Dolena Ledee
Protein O-GlcNAcylation is a dynamic post-translational modification with emerging roles in cardiac pathophysiology. The availability of different pan-specific antibodies to assess global O-GlcNAc levels, and variability in western blot res...