Microarray analysis of the primate luteal transcriptome during chorionic gonadotrophin administration simulating early pregnancy [0.03%]
用微阵列分析模拟早孕人胎盘催乳素对类固醇分泌和转录组的影响
C V Bishop,S Satterwhite,L Xu et al.
C V Bishop et al.
To explore chorionic gonadotrophin (CG)-regulated gene expression in the primate corpus luteum (CL), adult female rhesus macaques were treated in a model of simulated early pregnancy (SEP). Total RNA was isolated from individual CL after sp...
MicroRNA regulation via DNA methylation during the morula to blastocyst transition in mice [0.03%]
小鼠早期胚胎向胚囊过渡过程中DNA甲基化调控microRNA表达
Yee-Ming Lee,Huei-Wen Chen,Pawan Kumar Maurya et al.
Yee-Ming Lee et al.
Epigenetic regulation is responsible for transcriptional silencing of genes and parental imprinting. This study addresses the question whether microRNAs (miRNAs) could be affected by DNA methylation during morula-blastocyst transition. Mous...
Calcium signaling in mouse oocyte maturation: the roles of STIM1, ORAI1 and SOCE [0.03%]
小鼠卵母细胞成熟过程中STIM1、ORAI1和SOCE介导的钙信号作用机制研究
Carolina Gómez-Fernández,Aida M López-Guerrero,Eulalia Pozo-Guisado et al.
Carolina Gómez-Fernández et al.
Calcium handling is critical for the oocyte function, since the first steps of fertilization are dependent on the appropriate Ca(2+) mobilization to originate transient spikes of the cytosolic Ca(2+) concentration. It is well known that the...
Macrophages regulate expression of α1,2-fucosyltransferase genes in human endometrial epithelial cells [0.03%]
巨噬细胞调节人子宫内膜上皮细胞α1,2岩藻糖基转移酶基因的表达
Hitomi Nakamura,Melinda J Jasper,M Louise Hull et al.
Hitomi Nakamura et al.
The epithelial cell surface of the endometrium undergoes substantial biochemical changes to allow embryo attachment and implantation in early pregnancy. We hypothesized that tissue macrophages influence these events to promote uterine recep...
Association of the R67X and W303X non-sense polymorphisms in the protein Z-dependent protease inhibitor gene with idiopathic recurrent miscarriage [0.03%]
蛋白质Z依赖性蛋白酶抑制剂基因的R67X和W303X无义多态性与复发性自然流产的关系研究
F S AlShaikh,R R Finan,A W Almawi et al.
F S AlShaikh et al.
Protein Z-dependent protease inhibitor (ZPI) is a 72 kDa single-chain serpin which inhibits the activated coagulation factors X and XI. Two non-sense polymorphisms of ZPI, R67X and W303X, were recently identified, and were linked with a pro...
Gene expression profiling of placentae from women with early- and late-onset pre-eclampsia: down-regulation of the angiogenesis-related genes ACVRL1 and EGFL7 in early-onset disease [0.03%]
早发和晚发子痫前期胎盘基因表达谱的测定：早发子痫前期患者胎盘中与血管生成相关的重要基因ACVRL1和EGFL7表达下调
K Junus,M Centlow,A-K Wikström et al.
K Junus et al.
The underlying mechanisms behind the obstetric condition pre-eclampsia (PE) are still unclear. Manifestation of PE is heterogeneous and it has therefore been proposed to be a syndrome with different causes rather than one disease with a spe...
Human fallopian tube epithelium constitutively expresses integrin endometrial receptivity markers: no evidence for a tubal implantation window [0.03%]
人输卵管上皮细胞组成性表达整联蛋白子宫受容体型标记物：无子宫外植入窗口证据
J K Brown,J L V Shaw,H O D Critchley et al.
J K Brown et al.
Understanding of ectopic implantation within the Fallopian tube (FT) is limited. In the human uterus, the putative 'window of implantation' in the mid-luteal phase of the menstrual cycle is accompanied by increased endometrial epithelial ex...
Functional study of an aberrant splicing variant of the human luteinizing hormone (LH) receptor [0.03%]
人绒毛膜促性腺激素受体异常剪切变异体的功能研究
Bing Han,Zhi-quan Wang,Li-qiong Xue et al.
Bing Han et al.
The luteinizing hormone receptor (LHR) is a member of a subfamily of G protein-coupled receptors that is characterized by its alternative splicing. In a previous study, we identified a splice site mutation of intron 6 (IVS6-3C>A) in a patie...
A novel model of human implantation: 3D endometrium-like culture system to study attachment of human trophoblast (Jar) cell spheroids [0.03%]
人类着床的新模型：三维子宫内膜样培养体系研究人合胞体滋养层(Jar)细胞球的附着
Hai Wang,Federica Pilla,Sandra Anderson et al.
Hai Wang et al.
There is an urgent need to develop optimized experimental models to examine human implantation. These studies aimed to (i) establish a human endometrium-like three-dimensional (3D) culture system, and (ii) examine the attachment of trophobl...
MiR-199a attenuates endometrial stromal cell invasiveness through suppression of the IKKβ/NF-κB pathway and reduced interleukin-8 expression [0.03%]
微RNA-199a通过抑制IKKβ/ NF-κB通路和减少白细胞介素-8表达来减弱子宫内膜基质细胞的浸润能力
Lan Dai,Liying Gu,Wen Di
Lan Dai
MicroRNAs have recently been identified as regulators that modulate target gene expression and are suggested to be involved in the development and progression of endometriosis. This study was undertaken to analyze the expression level of mi...