Global gene analysis of oocytes from early stages in human folliculogenesis shows high expression of novel genes in reproduction [0.03%]
人类早期卵泡发生过程中卵母细胞的全球基因分析显示生殖新基因高表达
S Markholt,M L Grøndahl,E H Ernst et al.
S Markholt et al.
The pool of primordial follicles in humans is laid down during embryonic development and follicles can remain dormant for prolonged intervals, often decades, until individual follicles resume growth. The mechanisms that induce growth and ma...
A functional variant in ANGPT1 and the risk of pregnancies with hypertensive disorders and small-for-gestational-age infants [0.03%]
ANGPT1功能变异体与患有高血压疾病和宫内生长受限婴儿的妊娠风险关联性研究
Prabha H Andraweera,Gustaaf A Dekker,Steven D Thompson et al.
Prabha H Andraweera et al.
Pregnancies complicated by pre-eclampsia and small-for-gestational-age (SGA) infants demonstrate impaired placental vascular remodelling. Angiopoietin-1 (ANG-1) is an angiogenic growth factor which regulates vascular integrity and remodelli...
Multicenter Study
Molecular human reproduction. 2012 Jun;18(6):325-32. DOI:10.1093/molehr/gar081 2012
S J Silber
S J Silber
The aim of this review is to summarize the state-of-the-art of ovarian transplantation and cryopreservation. This field has progressed over the last half century from simple animal experiments to sophisticated application in humans. The ini...
Association of E-cadherin single nucleotide polymorphisms with the increased risk of endometriosis in Indian women [0.03%]
E-钙粘着蛋白单核苷酸多态性与印度女性子宫内膜异位症风险增加相关性研究
Suresh Govatati,Naveen Kumar Tangudu,Mamata Deenadayal et al.
Suresh Govatati et al.
The objective of the present study was to investigate the association between gene E-cadherin single nucleotide polymorphisms (SNPs) and risk of developing endometriosis in Indian women and to evaluate the role of E-cadherin expression in t...
Folic acid and safflower oil supplementation interacts and protects embryos from maternal diabetes-induced damage [0.03%]
叶酸和红花油补充相互作用保护胚胎免受母体糖尿病引起的损伤
R Higa,M Kurtz,M B Mazzucco et al.
R Higa et al.
Maternal diabetes increases the risk of embryo malformations. Folic acid and safflower oil supplementations have been shown to reduce embryo malformations in experimental models of diabetes. In this study we here tested whether folic acid a...
Embryo collection induces transient activation of XBP1 arm of the ER stress response while embryo vitrification does not [0.03%]
胚胎采集可诱导内质网压力反应中的XBP1臂的瞬时活化而玻璃化冷冻则不会
Tamara Abraham,Christopher L Pin,Andrew J Watson
Tamara Abraham
Embryo cryopreservation has become a standard procedure in the practice of assisted reproduction. While routinely performed in IVF labs, the effects of embryo vitrification on the molecular mechanisms governing preimplantation development r...
Phasic contractions of isolated human myometrium are associated with Rho-kinase (ROCK)-dependent phosphorylation of myosin phosphatase-targeting subunit (MYPT1) [0.03%]
分阶段收缩的分离人子宫平滑肌与Rho激酶（ROCK）依赖的肌球蛋白磷酸酶靶向亚基（MYPT1）磷酸化有关
Claire A Hudson,Kate J Heesom,Andrés López Bernal
Claire A Hudson
Force generation in smooth muscle is driven by phosphorylation of myosin light chains (MYL), which is regulated by the equilibrium between the activities of myosin light chain kinase (MYLK) and myosin phosphatase (MYLP). MYLK is activated b...
Changes in histone H4 acetylation during in vivo versus in vitro maturation of equine oocytes [0.03%]
马卵母细胞体外成熟和体内成熟过程中组蛋白H4乙酰化的变化规律研究
Federica Franciosi,Valentina Lodde,Ghylène Goudet et al.
Federica Franciosi et al.
Epigenetic modifications are established during gametogenesis and preimplantation embryonic development. Any disturbance of the normal natural environment during these critical phases could cause alterations of the epigenetic signature. His...
Gene expression is altered after bisphenol A exposure in human fetal oocytes in vitro [0.03%]
体外暴露双酚A后人类胎儿卵细胞基因表达的改变
M A Brieño-Enríquez,R Reig-Viader,L Cabero et al.
M A Brieño-Enríquez et al.
Bisphenol A (BPA) is a 'weak' endocrine disruptor. The effect of BPA on human reproduction is controversial but has been related to meiotic anomalies, recurrent spontaneous abortion, abnormal karyotypes, the diminishing of oocyte survival, ...
Regucalcin, a calcium-binding protein with a role in male reproduction? [0.03%]
一种在男性生殖中发挥作用的钙结合蛋白REGUCALCIN？
Sandra S Laurentino,Sara Correia,José Eduardo Cavaco et al.
Sandra S Laurentino et al.
Regucalcin (RGN) is a calcium (Ca(2+))-binding protein which plays an important role in the regulation of Ca(2+) homeostasis and has been shown to catalyse an important step in L-ascorbic acid biosynthesis. It is encoded by an X-linked gene...