Effects of interleukin-6 on extravillous trophoblast invasion in early human pregnancy [0.03%]
白细胞介素6对早期妊娠人绒毛外滋养细胞侵袭作用的影响
Hedele Champion,Barbara A Innes,Stephen C Robson et al.
Hedele Champion et al.
Invasion of uterine tissues by extravillous trophoblast cells (EVT) is essential for successful human pregnancy. EVT invasion is tightly regulated by a number of factors, including growth factors and cytokines, but the mechanisms that under...
Alteration in the processing of the ACRBP/sp32 protein and sperm head/acrosome malformations in proprotein convertase 4 (PCSK4) null mice [0.03%]
蛋白酶 PCSK4 基因敲除小鼠中 acrbp/sp32 蛋白修饰和精子头部/顶体畸形现象的研究
Steve Tardif,Benoit Guyonnet,Nathaly Cormier et al.
Steve Tardif et al.
Proprotein convertase 4 (PCSK4) is a member of a family of proprotein convertases that convert inactive precursor proteins into their mature and active forms. PCSK4 is expressed by testicular germ cells and localizes to the sperm acrosome, ...
Ovarian reserve status in young women is associated with altered gene expression in membrana granulosa cells [0.03%]
卵巢储备与年轻女性卵泡颗粒细胞基因表达有关联
Christine C Skiadas,Shenghua Duan,Mick Correll et al.
Christine C Skiadas et al.
Diminished ovarian reserve (DOR) is a challenging diagnosis of infertility, as there are currently no tests to predict who may become affected with this condition, or at what age. We designed the present study to compare the gene expression...
Nuclear factor-κB mediates placental growth factor induced pro-labour mediators in human placenta [0.03%]
核因子NF-κB介导人胎盘血管生成素诱导促 labour 中文消息介质
Martha Lappas
Martha Lappas
Prostaglandins, pro-inflammatory cytokines, extracellular matrix remodelling enzymes and nuclear factor-kappa B (NF-κB) are involved in the mechanisms of term and preterm parturition. Recent studies have reported an increase in angiogenesi...
Alterations in progesterone receptor membrane component 2 (PGRMC2) in the endometrium of macaques afflicted with advanced endometriosis [0.03%]
宫腔膜猴进行性子宫内膜异位症中孕酮受体膜组分2(PGRMC2)的改变
Christopher S Keator,Kuni Mah,Ov D Slayden
Christopher S Keator
The hormonally driven expression and cell-specific localization patterns of the progesterone receptor membrane components (PGRMC1 and PGRMC2) in the macaque endometrium during the menstrual cycle are unknown. Additionally, the expression an...
Modern methods of fertility preservation: a tribute to Roger Gosden [0.03%]
现代生育力保存方法：献给Roger Gosden教授
Stephen G Hillier
Stephen G Hillier
Depletion of bitter taste transduction leads to massive spermatid loss in transgenic mice [0.03%]
苦味传导的丧失导致转基因小鼠大量精子细胞丢失
Feng Li,Minliang Zhou
Feng Li
Bitter taste perception is an important sensory input warning against the ingestion of toxic and noxious substances. Bitter receptors, a family of ~30 highly divergent G-protein-coupled receptors, are exclusively expressed in taste receptor...
Apolipoprotein E polymorphisms and spontaneous pregnancy loss in patients with endometriosis [0.03%]
多态性与子宫内膜异位症患者的自然流产风险关系的研究
Madeline S Collazo,Tirtsa Porrata-Doria,Idhaliz Flores et al.
Madeline S Collazo et al.
Endometriosis affects >10% of women during their reproductive years, many of whom report high rates of spontaneous pregnancy loss (SPL). We examined whether gene polymorphisms in apolipoprotein E (APOE), which is involved in lipoprotein met...
Oxysterols exert proinflammatory effects in placental trophoblasts via TLR4-dependent, cholesterol-sensitive activation of NF-κB [0.03%]
角鲨烯醇通过依赖TLR4、胆固醇敏感的NF-κB活化在胎盘滋养细胞中发挥促炎症效应
Irving L M H Aye,Brendan J Waddell,Peter J Mark et al.
Irving L M H Aye et al.
Oxidized cholesterol metabolites (oxysterols) promote inflammation in a variety of cell types and are thought to be involved in a number of disease pathologies. Oxysterol concentrations are increased in pregnancy, together with systemic oxi...
Association study of CYP17 and HSD11B1 in polycystic ovary syndrome utilizing comprehensive gene coverage [0.03%]
针对多囊卵巢综合征进行的CYP17和HSD11B1综合基因范围关联研究
Angela K Chua,Ricardo Azziz,Mark O Goodarzi
Angela K Chua
Cytochrome P450-C17 enzyme (CYP17) is an important component of the androgen synthesis pathway, a pathway that is dysfunctional in polycystic ovary syndrome (PCOS). Variation in 11-beta hydroxysteroid dehydrogenase (HSD11B1) is associated w...