Is germline transmission of MAD2 gene deletion associated with human fetal loss? [0.03%]
MAD2基因缺失的生殖系传递与人类胎停育有关吗？
Somsubhra Nath,Mrinalini Moghe,Abhishek Chowdhury et al.
Somsubhra Nath et al.
The spindle assembly checkpoint (SAC) monitors proper attachment of spindles to the kinetochore during mitotic and meiotic cell divisions and thus prevents aneuploidy. Chromosomal aneuploidy has been found to be associated with pregnancy lo...
Metabolomic biomarkers in women with polycystic ovary syndrome: a pilot study [0.03%]
多囊卵巢综合征女性代谢组生物标志物的探索性研究
W Atiomo,C A Daykin
W Atiomo
The aim of this study was to investigate whether women with polycystic ovary syndrome (PCOS) had a unique metabolomic profile that was different from controls and to assess the feasibility of a definitive study. Twelve women with PCOS and 1...
Divergence of sperm and leukocyte age-dependent telomere dynamics: implications for male-driven evolution of telomere length in humans [0.03%]
精子和白细胞年龄依赖性端粒动力学的差异：对人类中由男性驱动的端粒长度进化的影响
Kenneth I Aston,Steven C Hunt,Ezra Susser et al.
Kenneth I Aston et al.
Telomere length (TL) dynamics in vivo are defined by TL and its age-dependent change, brought about by cell replication. Leukocyte TL (LTL), which reflects TL in hematopoietic stem cells (HSCs), becomes shorter with age. In contrast, sperm ...
Aberrant expression of corticotropin-releasing hormone in pre-eclampsia induces expression of FasL in maternal macrophages and extravillous trophoblast apoptosis [0.03%]
皮质醇释放激素在先兆子痫的异常表达可诱导母体巨噬细胞FasL和蜕膜血管侵袭性滋养层凋亡
G Petsas,U Jeschke,D U Richter et al.
G Petsas et al.
Corticotropin-releasing hormone (CRH) and its receptors are expressed in human placenta. Recently, the impaired function of this system has been associated with a number of complications of pregnancy, including pre-eclampsia. The aim of the...
Note of clarification of data in the meta-analysis of methylenetetrahydrofolate reductase C677T polymorphisms in polycystic ovary syndrome [0.03%]
多囊卵巢综合征甲基四氢叶酸还原酶C677T基因型Meta分析的澄清说明
Ying Chan,Futing Zi,Xiaoming Wu et al.
Ying Chan et al.
Negative association between androgen receptor gene CAG repeat polymorphism and polycystic ovary syndrome? A systematic review and meta-analysis [0.03%]
雄激素受体基因CAG多态性与多囊卵巢综合征负相关吗？系统评价和Meta分析
Rui Wang,Mark O Goodarzi,Ting Xiong et al.
Rui Wang et al.
A number of studies focusing on the association between the exon 1 CAG repeat polymorphism of the androgen receptor (AR) gene and polycystic ovary syndrome (PCOS) have revealed conflicting results. The current systematic review and meta-ana...
The pluripotency factor LIN28 in monkey and human testes: a marker for spermatogonial stem cells? [0.03%]
灵长动物和人类睾丸中的多能性因子LIN28：一种未分化生精干细胞的标志物？
N Aeckerle,K Eildermann,C Drummer et al.
N Aeckerle et al.
Mammalian spermatogenesis is maintained by spermatogonial stem cells (SSCs). However, since evidentiary assays and unequivocal markers are still missing in non-human primates (NHPs) and man, the identity of primate SSCs is unknown. In contr...
The M2 haplotype in the ANXA5 gene is an independent risk factor for idiopathic small-for-gestational age newborns [0.03%]
ANXA5基因的M2单体型是原发性宫内发育迟缓的独立危险因素
G Tiscia,D Colaizzo,G Favuzzi et al.
G Tiscia et al.
Hereditary thrombophilias can impair vascular placental functions and predispose to the birth of small-for-gestational age (SGA) babies. The placental anticoagulant protein annexin A5 (ANXA5) may contribute to this process. A functional hap...
Seminal plasma microRNAs: potential biomarkers for spermatogenesis status [0.03%]
精浆微小核糖核酸：潜在的生精状态生物标志物
Wei Wu,Zhibin Hu,Yufeng Qin et al.
Wei Wu et al.
MicroRNAs (miRNAs) are small non-coding RNAs (18-25 nt), playing important regulatory roles via interaction with cellular messenger RNAs. The altered expression of miRNAs in specific tissues has been associated with diseases such as cancer ...
Inhibition of IDO1 suppresses cyclooxygenase-2 and matrix metalloproteinase-9 expression and decreases proliferation, adhesion and invasion of endometrial stromal cells [0.03%]
IDO1抑制可下调子宫内膜基质细胞的COX-2及MMP-9表达并抑制其增殖、黏附和侵袭能力
Jie Mei,Li-Ping Jin,Ding Ding et al.
Jie Mei et al.
Indoleamine 2,3-dioxygenase-1 (IDO1) is an intracellular enzyme that catalyses essential amino acid tryptophan along the kynurenine pathway. The aim of this study was to determine the impact of IDO1 expression on the biological characterist...