ADP-ribosylation factor-like 3, a manchette-associated protein, is essential for mouse spermiogenesis [0.03%]
ADP核糖基化因子样物3是一种与小管蛋白相关联的蛋白质，对小鼠精子生成过程必不可少
Yujuan Qi,Min Jiang,Yan Yuan et al.
Yujuan Qi et al.
During spermiogenesis, the manchette is an important structure for sperm head and tail formation. However, the mechanisms responsible for this process are poorly understood. In a previous study, we established a comparative proteome profile...
Minerva Mata-Rocha,Edith Alvarado-Cuevas,Javier Hernández-Sánchez et al.
Minerva Mata-Rocha et al.
CatSper channels are essential for hyperactivity of sperm flagellum, progesterone-mediated chemotaxis and oocyte fertilization. Catsper genes are exclusively expressed in the testis during spermatogenesis, but the function and regulation of...
Implantation failure in mice with a disruption in Phospholipase C beta 1 gene: lack of embryonic attachment, aberrant steroid hormone signalling and defective endocannabinoid metabolism [0.03%]
磷脂酶Cβ1基因缺失小鼠的着床失败：胚胎缺乏附植、类固醇激素信号异常和内源大麻素代谢缺陷
Panayiotis Filis,Peter C Kind,Norah Spears
Panayiotis Filis
Phospholipase C beta 1 (PLCβ1) is a downstream effector of G-protein-coupled receptor signalling and holds central roles in reproductive physiology. Mice with a disruption in the Plcβ1 gene are infertile with pleiotropic reproductive defe...
ART and health: clinical outcomes and insights on molecular mechanisms from rodent studies [0.03%]
艺术与健康：来自小鼠研究的临床结果和分子机制见解
S K Feuer,L Camarano,P F Rinaudo
S K Feuer
Since the birth of the first IVF-conceived child in 1978, the use of assisted reproductive technologies (ART) has grown dramatically, contributing to the successful birth of 5 million individuals worldwide. However, there are several report...
The search for biomarkers of human embryo developmental potential in IVF: a comprehensive proteomic approach [0.03%]
一种全面的蛋白质组学方法寻找IVF中人类胚胎发育潜能的生物标志物
Julius Nyalwidhe,Tanya Burch,Silvina Bocca et al.
Julius Nyalwidhe et al.
The objective of these studies was to identify differentially expressed peptides/proteins in the culture media of embryos grown during in vitro fertilization (IVF) treatment to establish their value as biomarkers predictive of implantation ...
Investigation of the mechanisms by which the molecular chaperone HSPA2 regulates the expression of sperm surface receptors involved in human sperm-oocyte recognition [0.03%]
HSPA2分子伴侣调控人类精子卵透明带识别受体的机制研究
Kate A Redgrove,Amanda L Anderson,Eileen A McLaughlin et al.
Kate A Redgrove et al.
A unique characteristic of mammalian spermatozoa is that, upon ejaculation, they are unable to recognize and bind to an ovulated oocyte. These functional attributes are only realized following the cells' ascent of the female reproductive tr...
A P Sobinoff,J M Sutherland,E A Mclaughlin
A P Sobinoff
Female reproductive potential is dictated by the size of the primordial follicle pool and the correct regulation of oocyte maturation and activation--events essential for production of viable offspring. Although a substantial body of work u...
Effect of cyclic AMP and estrogen/progesterone on the transcription of DNA methyltransferases during the decidualization of human endometrial stromal cells [0.03%]
环AMP和雌/孕激素对人类子宫内膜间质细胞蜕膜化过程中DNA甲基转移酶转录的影响
Philip C Logan,Anna P Ponnampalam,Michael Steiner et al.
Philip C Logan et al.
Progesterone, estrogen and cyclic adenosine monophosphate (cAMP) together regulate the decidualization of human endometrial stromal cells in a time-dependent manner. The role of DNA methylation and the three active DNA methyltransferases (D...
Justin St John
Justin St John
CCN3 regulates proliferation and migration properties in Jeg3 trophoblast cells via ERK1/2, Akt and Notch signalling [0.03%]
CCN3通过ERK1/2、Akt和Notch信号调节Jeg3滋养细胞的增殖和迁移特性
Jessica Wagener,Wei Yang,Kathrin Kazuschke et al.
Jessica Wagener et al.
Previous studies showed that CCN3 is deregulated in early-onset pre-eclampsia (PE), a pregnancy disease associated with impaired trophoblast invasion, which leads to reduced fetal oxygen and nutrition support. Recently, we identified the gl...