Where the rubber hits the road: the translational pulse of reproductive biology [0.03%]
落地开花：生殖生物学的成果转化之途
Christopher L R Barratt
Christopher L R Barratt
Feng Li
Feng Li
In mammals, the sense of taste helps in the evaluation and consumption of nutrients, and in avoiding toxic substances and indigestible materials. Distinct cell types expressing unique receptors detect each of the five basic tastes: salty, s...
Genetic dissection of the pre-eclampsia susceptibility locus on chromosome 2q22 reveals shared novel risk factors for cardiovascular disease [0.03%]
染色体2q22的子痫前期易感位点的基因组离散分析发现心血管疾病的共有新型危险因素
Matthew P Johnson,Shaun P Brennecke,Christine E East et al.
Matthew P Johnson et al.
Pre-eclampsia is an idiopathic pregnancy disorder promoting morbidity and mortality to both mother and child. Delivery of the fetus is the only means to resolve severe symptoms. Women with pre-eclamptic pregnancies demonstrate increased ris...
Genetic variation in TGFB1 gene and risk of idiopathic recurrent pregnancy loss [0.03%]
转化生长因子TGFB1基因多态性与反复自然流产关系的研究进展
K Magdoud,V Granados Herbepin,S Messaoudi et al.
K Magdoud et al.
Transforming growth factor β1 plays a significant role in pregnancy outcome. We investigated the association of TGFB1 exon 1 (rs1800471, rs1800470) and promoter region (rs1800469, rs1800468) polymorphisms with recurrent pregnancy loss (RPL...
UBE2B mRNA alterations are associated with severe oligozoospermia in infertile men [0.03%]
UBE2B mRNA改变与男性不育重度少精子症的关系
Alexander N Yatsenko,Andrew P Georgiadis,Lata J Murthy et al.
Alexander N Yatsenko et al.
Oligozoospermia (low sperm count) is a common semen deficiency. However, to date, few genetic defects have been identified to cause this condition. Moreover, even fewer molecular genetic diagnostic tests are available for patients with olig...
Gene expression analysis reveals an angiogenic profile in uterine leiomyoma pseudocapsule [0.03%]
基因表达分析揭示了子宫肌瘤假包膜的血管生成表型
S Di Tommaso,S Massari,A Malvasi et al.
S Di Tommaso et al.
The pseudocapsule (PC) of the uterine leiomyoma (UL) is an anatomic entity that surrounds the myoma separating it from the myometrium (UM). Although a number of microarray experiments have identified differences in gene expression profile i...
Thrombopoietin modulates the proliferation, migration and cytokine profile of decidual cell subsets during early gestation [0.03%]
血小板生成素在早孕期通过调节蜕膜细胞亚群的增殖、迁移和细胞因子谱型来参与妊娠调控
S E Segerer,F Martignoni,A Bogdan et al.
S E Segerer et al.
During early gestation, a considerable increase in different leukocyte subsets can be observed in the decidualized endometrium concomitantly to the invasion of cytotrophoblast cells (CTB). To date, it is still in question which factors indu...
Evolutionary conservation of the oocyte transcriptome among vertebrates and its implications for understanding human reproductive function [0.03%]
脊椎动物卵母细胞转录组的进化保守性及其对理解人类生殖功能的意义
Eve-Lyne Sylvestre,Claude Robert,Sophie Pennetier et al.
Eve-Lyne Sylvestre et al.
Cross-phylum and cross-species comparative transcriptomic analyses provide an evolutionary perspective on how specific tissues use genomic information. A significant mRNA subset present in the oocytes of most vertebrates is stabilized or st...
Matteo A Avella,Bo Xiong,Jurrien Dean
Matteo A Avella
Successful fertilization heralds the onset of development and requires both gamete recognition and a definitive block to polyspermy. Sperm initially bind and penetrate the extracellular zona pellucida (ZP) that surrounds ovulated eggs, but ...
Visfatin is expressed in human granulosa cells: regulation by metformin through AMPK/SIRT1 pathways and its role in steroidogenesis [0.03%]
人颗粒细胞中视 fatin 的表达：二甲双胍通过AMPK / SIRT1通路对其调节及其在类固醇生成中的作用
Maxime Reverchon,Marion Cornuau,Lucie Cloix et al.
Maxime Reverchon et al.
Visfatin is a cytokine hormone and an enzyme involved in metabolic (obesity, type II diabetes) and immune disorders. Some data suggest a role of visfatin in ovarian function. Here, we identified visfatin in human follicles and investigated ...