SUN5 interacts with nuclear membrane LaminB1 and cytoskeletal GTPase Septin12 mediating the sperm head-and-tail junction [0.03%]
太阳五通过介导精子头部-尾部连接与核膜层粘连蛋白B1和细胞骨架GTP酶Septin12相互作用
Yunfei Zhang,Gang Liu,Lihua Huang et al.
Yunfei Zhang et al.
Acephalic spermatozoa syndrome (ASS) is a severe teratospermia with decaudated, decapitated, and malformed sperm, resulting in male infertility. Nuclear envelope protein SUN5 localizes to the junction between the sperm head and tail. Mutati...
Single-cell proteomics reveals decreased abundance of proteostasis and meiosis proteins in advanced maternal age oocytes [0.03%]
单细胞蛋白质组学揭示卵母细胞中蛋白质稳态和减数分裂相关蛋白含量随着母亲年龄的增长而减少
Styliani Galatidou,Aleksandra A Petelski,Aïda Pujol et al.
Styliani Galatidou et al.
Advanced maternal age is associated with a decline in oocyte quality, which often leads to reproductive failure in humans. However, the mechanisms behind this age-related decline remain unclear. To gain insights into this phenomenon, we app...
Reina Komatsu,Hitomi Nakamura,Takayoshi Hosono et al.
Reina Komatsu et al.
Preterm birth is a serious pregnancy complication that affects neonatal mortality, morbidity, and long-term neurological prognosis. Predicting spontaneous preterm delivery (PTD) is important for its management. While excluding the risk of P...
Murine uterine gland branching is necessary for gland function in implantation [0.03%]
小鼠子宫腺分支是受精卵着床时发挥腺体功能的必要条件
Katrina Granger,Sarah Fitch,May Shen et al.
Katrina Granger et al.
Uterine glands are branched, tubular structures whose secretions are essential for pregnancy success. It is known that pre-implantation glandular expression of leukemia inhibitory factor (LIF) is crucial for embryo implantation; however, th...
Extracellular vesicles secreted by cumulus cells contain microRNAs that are potential regulatory factors of mouse oocyte developmental competence [0.03%]
放射冠细胞分泌的外泌体含有小RNA分子，这些分子可能是小鼠卵母细胞发育潜能的调控因子
Giulia Fiorentino,Valeria Merico,Mario Zanoni et al.
Giulia Fiorentino et al.
The role of cumulus cells (CCs) in the acquisition of oocyte developmental competence is not yet fully understood. In a previous study, we matured cumulus-denuded fully-grown mouse oocytes to metaphase II (MII) on a feeder layer of CCs (FL-...
In vivo effect of vaginal seminal plasma application on the human endometrial transcriptome: a randomized controlled trial [0.03%]
人乳头状瘤病毒阴性的中国女性接种HPV-16/18AS04型疫苗免疫原性：一项随机对照研究
Laura Catalini,Mark Burton,Dorte L Egeberg et al.
Laura Catalini et al.
Studies in humans and animals suggest that seminal plasma, the acellular seminal fluid component, stimulates the endometrium to promote immune tolerance and facilitate implantation. We designed a randomized, double-blinded, placebo-controll...
Randomized Controlled Trial
Molecular human reproduction. 2024 Mar 28;30(5):gaae017. DOI:10.1093/molehr/gaae017 2024
Paxillin regulates androgen receptor expression associated with granulosa cell focal adhesions [0.03%]
波形蛋白调节与颗粒细胞焦粘附相关的雄激素受体表达
Adelaide E Weidner,Anna Roy,Kenji Vann et al.
Adelaide E Weidner et al.
Paxillin is a ubiquitously expressed adaptor protein integral to focal adhesions, cell motility, and apoptosis. Paxillin has also recently been implicated as a mediator of nongenomic androgen receptor (AR) signaling in prostate cancer and o...
Methyl-CpG-binding protein 2 regulates CYP27A1-induced myometrial contraction during preterm labor [0.03%]
甲基胞嘧啶 CG 基序结合蛋白 2 在早产期间通过 CYP27A1 调节子宫平滑肌收缩
Ting Peng,Jiayan Cui,Ziyun Ni et al.
Ting Peng et al.
Persistent and intense uterine contraction is a risk factor for preterm labor. We previously found that methyl-CpG-binding protein 2 (MeCP2), as a target of infection-related microRNA miR-212-3p, may play an inhibitory role in regulating my...
Cellular senescence of granulosa cells in the pathogenesis of polycystic ovary syndrome [0.03%]
颗粒细胞衰老在多囊卵巢综合征发病机制中的作用
Tsurugi Tanaka,Yoko Urata,Miyuki Harada et al.
Tsurugi Tanaka et al.
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women of reproductive age, but its pathology has not been fully characterized and the optimal treatment strategy remains unclear. Cellular senescence is a per...
A new initiative for 2024: increasing peer review transparency at MHR [0.03%]
2024年新举措：在MHR增加同行评审透明度
Michele Boiani,Francesca E Duncan
Michele Boiani