Reduced oxygen concentrations regulate the phenotype and function of human granulosa cells in vitro and cause a diminished steroidogenic but increased inflammatory cellular reaction [0.03%]
降低氧浓度调节人类颗粒细胞的表型和功能并且引起类固醇生成减少但是炎症反应增加的细胞反应
Maria Höfner,Katja Eubler,Carola Herrmann et al.
Maria Höfner et al.
Oxygen (O2) concentrations have recently been discussed as important regulators of ovarian cells. Human IVF-derived granulosa cells (human GCs) can be maintained in vitro and are a widely used cellular model for the human ovary. Typically, ...
Reply: The FSH OoToxicity (FOOT) hypothesis and the 2-Hit hypothesis-new hypotheses that are different from the hypotheses of Buratini et al [0.03%]
回复：FSH 毒性（FOOT）假说和两击假说-与Buratini等人的假设不同的新假说
Lori R Bernstein,Amelia C L Mackenzie,Duane C Kraemer et al.
Lori R Bernstein et al.
Evidence of FSH-ootoxicity from the mouse model: recognition of an important work and a note on the novelty of the hypothesis [0.03%]
来自小鼠模型的FSH-ootoxicity证据：对一项重要工作的认可及关于该假设新颖性的说明
Jose Buratini,Mariabeatrice Dal Canto,Mario Mignini Renzini et al.
Jose Buratini et al.
Endometrial stromal cell autophagy-dependent ferroptosis caused by iron overload in ovarian endometriosis is inhibited by the ATF4-xCT pathway [0.03%]
铁过载诱导的卵巢子宫内膜异位症合体细胞自噬依赖性铁死亡通过激活ATF4-xCT通路被抑制
Xiaoyu Dong,Le Xu,Shuang Wang et al.
Xiaoyu Dong et al.
Ferroptosis is an iron-dependent programmed cell death process characterized by the accumulation of lethal oxidative damage. Localized iron overload is a unique clinical phenomenon in ovarian endometriosis (EM). However, the role and mechan...
Human placental vascular and perivascular cell heterogeneity differs between first trimester and term, and in pregnancies affected by foetal growth restriction [0.03%]
人胎盘血管和周围血管细胞异质性在早孕期与足月期不同，并且在受胎儿生长受限影响的妊娠中也有所不同
Anna L Boss,Lawrence W Chamley,Anna E S Brooks et al.
Anna L Boss et al.
Growth-restricted placentae have a reduced vascular network, impairing exchange of nutrients and oxygen. However, little is known about the differentiation events and cell types that underpin normal/abnormal placental vascular formation and...
Aggregated chromosomes/chromatin transfer: a novel approach for mitochondrial replacement with minimal mitochondrial carryover: the implications of mouse experiments for human aggregated chromosome transfer [0.03%]
聚集型染色体/染色质移植：一种新型的线粒体置换方法，可使残留的线粒体最少化：小鼠实验对人类聚集染色体转移的意义
R Okamoto,W Xiao,H Fukasawa et al.
R Okamoto et al.
Nuclear transfer techniques, including spindle chromosome complex (SC) transfer and pronuclear transfer, have been employed to mitigate mitochondrial diseases. Nevertheless, the challenge of mitochondrial DNA (mtDNA) carryover remains unres...
GM-CSF improves endometrial receptivity in a thin endometrium rat model by upregulating HOXA10 [0.03%]
GM-CSF通过上调HOXA10改善薄型子宫内膜容受性的小鼠模型研究
Wei Wei,Na Wang,Yanwen Zhu et al.
Wei Wei et al.
Endometrial receptivity is a prerequisite for the success of assisted reproduction. Patients with a consistently thin endometrium frequently fail to conceive, owing to low endometrial receptivity, and there are currently very few therapeuti...
Advanced maternal age leads to changes within the insulin/IGF system and lipid metabolism in the reproductive tract and preimplantation embryo: insights from the rabbit model [0.03%]
高级产妇年龄会导致生殖道和植入前胚胎中的胰岛素/IGF系统和脂质代谢发生变化：兔模型的启示
Juliane Trohl,Maria Schindler,Maximilian Buske et al.
Juliane Trohl et al.
Reproductive potential in women declines with age. The impact of ageing on embryo-maternal interactions is still unclear. Rabbits were used as a reproductive model to investigate maternal age-related alterations in reproductive organs and e...
Human follicular fluid elicits select dose- and age-dependent effects on mouse oocytes and cumulus-oocyte complexes in a heterologous in vitro maturation assay [0.03%]
人卵泡液通过异种体外成熟体系对小鼠不同年龄阶段的GV期卵母细胞及丛集卵母细胞复合体具有剂量和年龄依赖性的效应
Shweta S Dipali,Chanakarn Suebthawinkul,Joanna E Burdette et al.
Shweta S Dipali et al.
Follicular fluid (FF) is a primary microenvironment of the oocyte within an antral follicle. Although several studies have defined the composition of human FF in normal physiology and determined how it is altered in disease states, the dire...