S Turner,G M Hartshorne
S Turner
Telomeres are chromosome ends that control functions related to cell division. Short telomeres are proposed to underlie infertility, female reproductive ageing and abnormal embryogenesis, but there is little direct evidence on telomere leng...
Marie-Chantal Grégoire,Julien Massonneau,Olivier Simard et al.
Marie-Chantal Grégoire et al.
At the sequence level, genetic diversity is provided by de novo transmittable mutations that may act as a substrate for natural selection. The gametogenesis process itself is considered more likely to induce endogenous mutations and a clear...
Maternal NLRP7 and C6orf221 variants are not a common risk factor for androgenetic moles, triploidy and recurrent miscarriage [0.03%]
母体NLRP7和C6orf221变异不是男性特发性葡萄胎、三倍体和复发性流产的常见危险因素
I Manokhina,C W Hanna,M D Stephenson et al.
I Manokhina et al.
Maternal effect genes control early events of embryogenesis. Maternal homozygous and compound mutations in two such genes, NLRP7 and c6orf221, have been detected in the majority of women experiencing recurrent biparental hydatidiform moles....
Epigenetics of gestational diabetes mellitus and offspring health: the time for action is in early stages of life [0.03%]
妊娠期糖尿病的表观遗传学与子代健康：行动的时间是在生命早期阶段
Harald Lehnen,Ulrich Zechner,Thomas Haaf
Harald Lehnen
The epidemic increase of type 2 diabetes and obesity in developed countries cannot be explained by overnutrition, physical inactivity and/or genetic factors alone. Epidemiologic evidence suggests that an adverse intrauterine environment, in...
DPY19L2 gene mutations are a major cause of globozoospermia: identification of three novel point mutations [0.03%]
DPY19L2基因突变是造成圆头精子症的主要原因：新发现三种该基因的点突变
Fuxi Zhu,Fei Gong,Ge Lin et al.
Fuxi Zhu et al.
Globozoospermia, characterized by round-headed spermatozoa without acrosomes, is a rare and severe teratozoospermia causing primary male infertility. Homozygous DPY19L2 deletions have been identified as the main cause of globozoospermia, bl...
Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium [0.03%]
姜黄素、芸皮苷和芹菜素通过减少炎症和收缩途径来降低感染诱导的妊娠并发症风险
Ratana Lim,Gillian Barker,Courtney A Wall et al.
Ratana Lim et al.
A tenet of contemporary obstetrics is that a significant proportion of preterm births involve bacterial infection. Bacterial endotoxin induces pro-inflammatory cytokines, prostaglandins and proteases via the pro-inflammatory pathway nuclear...
Leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5) as a putative human endometrial stem cell marker [0.03%]
白蛋白丰富的重复包含G-蛋白耦联受体5(Lgr5)作为人类子宫内膜干细胞标志物的鉴定
C Gil-Sanchis,I Cervelló,A Mas et al.
C Gil-Sanchis et al.
The endometrium is recognized for its remarkable regenerative and remodeling capacity. Every month this hormonally regulated organ undergoes cycles of growth (from 0.5-2 to 7 mm), regression and shedding of two-third of the tissue, leading ...
Conditional deletion of Tsc1 in the female reproductive tract impedes normal oviductal and uterine function by enhancing mTORC1 signaling in mice [0.03%]
Tsc1基因条件性敲除使小鼠输卵管和子宫功能受损并增强mTORC1信号通路
Takiko Daikoku,Mikihiro Yoshie,Huirong Xie et al.
Takiko Daikoku et al.
Heightened mammalian target of rapamycin complex 1 (mTORC1) activity by genetic deletion of its direct inhibitor, Tsc1, is associated with aberrant development and dysfunction of the female reproductive tract in mice. Here, we compared the ...
The activity and copy number of mitochondrial DNA in ovine oocytes throughout oogenesis in vivo and during oocyte maturation in vitro [0.03%]
绵羊卵母细胞体内发生及体外成熟过程中线粒体DNA活性及拷贝数的变化规律
Matthew Cotterill,Sarah E Harris,Esther Collado Fernandez et al.
Matthew Cotterill et al.
Mitochondria are responsible for the production of ATP, which drives cellular metabolic and biosynthetic processes. This is the first study to quantify the mtDNA copy number across all stages of oogenesis in a large monovulatory species, it...
Dagan Wells,Stephen G Hillier
Dagan Wells