Critical role of hyaluronidase-2 during preimplantation embryo development [0.03%]
透明质酸酶-2在植入前胚胎发育中的critical作用
Waleed F A Marei,Mazdak Salavati,Ali A Fouladi-Nashta
Waleed F A Marei
Biological functions of hyaluronan (HA) depend on its molecular size. Small size HAs are known to regulate cell proliferation; however, the expression of HA synthases (HASs) and hyaluronidase-2 (HYAL2) and their role during early embryo dev...
Paul S Cooke,Thomas E Spencer,Frank F Bartol et al.
Paul S Cooke et al.
Development of uterine glands (adenogenesis) in mammals typically begins during the early post-natal period and involves budding of nascent glands from the luminal epithelium and extensive cell proliferation in these structures as they grow...
The association of maternal ACE A11860G with small for gestational age babies is modulated by the environment and by fetal sex: a multicentre prospective case-control study [0.03%]
母体ACE A11860G基因多态性与小胎龄儿的关系受环境和胎儿性别影响：一项多中心病例对照研究
Ang Zhou,Gustaaf A Dekker,Eugenie R Lumbers et al.
Ang Zhou et al.
We aimed to determine whether the ACE A11860G genotype is associated with small for gestational age babies (SGA) and to determine whether the association is affected by environmental factors and fetal sex. Overall, 3234 healthy nulliparous ...
Clinical Trial
Molecular human reproduction. 2013 Sep;19(9):618-27. DOI:10.1093/molehr/gat029 2013
Sperm parameters and epididymis function in transgenic rats overexpressing the Ca2+-binding protein regucalcin: a hidden role for Ca2+ in sperm maturation? [0.03%]
钙结合蛋白regucalcin过表达转基因大鼠的精子参数和附睾功能：钙在精子成熟中隐藏的作用？
S Correia,P F Oliveira,P M Guerreiro et al.
S Correia et al.
Sperm undergo maturation acquiring progressive motility and the ability to fertilize oocytes through exposure to the components of the epididymal fluid (EF). Although the establishment of a calcium (Ca(2+)) gradient along the epididymis has...
Maternal obesity, infertility and mitochondrial dysfunction: potential mechanisms emerging from mouse model systems [0.03%]
母体肥胖、不孕不育和线粒体功能障碍：来自小鼠模型系统的潜在机制
Natalia M Grindler,Kelle H Moley
Natalia M Grindler
Obesity is associated with ovulatory disorders, decreased rates of conception, infertility, early pregnancy loss and congenital abnormalities. Poor oocyte quality and reduced IVF success have also been reported in obese women. Recent attemp...
The dormant and the fully competent oocyte: comparing the transcriptome of human oocytes from primordial follicles and in metaphase II [0.03%]
人类卵巢原始卵泡中休眠和成熟的卵母细胞的转录组比较研究
Marie Louise Grøndahl,Rehannah Borup,Jonas Vikeså et al.
Marie Louise Grøndahl et al.
Oocytes become enclosed in primordial follicles during fetal life and remain dormant there until activation followed by growth and meiotic resumption. Current knowledge about the molecular pathways involved in oogenesis is incomplete. This ...
Comparative Study
Molecular human reproduction. 2013 Sep;19(9):600-17. DOI:10.1093/molehr/gat027 2013
Mode of oocyte maturation affects EGF-like peptide function and oocyte competence [0.03%]
卵母细胞成熟方式影响EGF样肽的功能及卵母细胞的能力
D Richani,L J Ritter,J G Thompson et al.
D Richani et al.
The function and impact of epidermal growth factor (EGF)-like peptide signalling during ovulation and in vivo oocyte maturation (IVV) has been recently characterized, however, little is currently known about the effect of oocyte in vitro ma...
Which follicles make the most anti-Mullerian hormone in humans? Evidence for an abrupt decline in AMH production at the time of follicle selection [0.03%]
人类中哪一类卵泡产生最多的抗穆勒管激素？关于在卵泡选择时AMH的生成量骤减的证据
J V Jeppesen,R A Anderson,T W Kelsey et al.
J V Jeppesen et al.
Anti-Müllerian hormone (AMH) is exclusively produced by granulosa cells (GC) of the developing pre-antral and antral follicles, and AMH is increasingly used to assess ovarian function. It is unclear which size follicles make the most AMH (...
The source and significance of DNA damage in human spermatozoa; a commentary on diagnostic strategies and straw man fallacies [0.03%]
人精子DNA损伤的来源及意义；有关诊断策略以及稻草人谬论的述评
R J Aitken,R Bronson,T B Smith et al.
R J Aitken et al.
This article considers the origins of DNA damage in human spermatozoa, the methods that are available to monitor this aspect of semen quality and the clinical significance of such measurements. DNA damage in spermatozoa appears to be largel...
Cytokine IL-6 secretion by trophoblasts regulated via sphingosine-1-phosphate receptor 2 involving Rho/Rho-kinase and Rac1 signaling pathways [0.03%]
鞘氨醇-1-磷酸受体2通过Rho/ ROCK和Rac1信号通路调控细胞滋养巨集球的白介素6分泌
Pankaj Goyal,Daniela Brünnert,Jens Ehrhardt et al.
Pankaj Goyal et al.
Various cytokines derived from placental cells are essential for normal placenta development and successful pregnancy. Interleukin-6 (IL-6) is a multifunctional cytokine produced by extravillous and cytotrophoblasts regulating the functions...