Widespread DNA hypomethylation at gene enhancer regions in placentas associated with early-onset pre-eclampsia [0.03%]
与早期子痫前期相关的胎盘基因增强区DNA低甲基化现象广泛存在
John D Blair,Ryan K C Yuen,Brendan K Lim et al.
John D Blair et al.
Pre-eclampsia is a serious complication of pregnancy that can affect both maternal and fetal outcomes. Early-onset pre-eclampsia (EOPET) is a severe form of pre-eclampsia that is associated with altered physiological characteristics and gen...
Homeobox gene transforming growth factor β-induced factor-1 (TGIF-1) is a regulator of villous trophoblast differentiation and its expression is increased in human idiopathic fetal growth restriction [0.03%]
家盒基因转化生长因子β诱导因子-1（TGIF-1）可调节绒毛滋养细胞的分化并在人特发性胎儿生长受限中表达上调
Niroshani A Pathirage,Melanie Cocquebert,Yoel Sadovsky et al.
Niroshani A Pathirage et al.
Abnormal trophoblast function is associated with human fetal growth restriction (FGR). Targeted disruption of homeobox gene transforming growth β-induced factor (TGIF-1) results in placental dysfunction in the mouse. The role of human TGIF...
Stephen Publicover
Stephen Publicover
Chemokine CCL28 induces apoptosis of decidual stromal cells via binding CCR3/CCR10 in human spontaneous abortion [0.03%]
趋化因子CCL28在人自发流产中通过结合CCR3/CCR10诱导蜕膜间质细胞凋亡
Chan Sun,Yuan-Yuan Zhang,Chuan-Ling Tang et al.
Chan Sun et al.
Spontaneous abortion is the most common complication of pregnancy. Immune activation and the subsequent inflammation-induced tissue injury are often observed at the maternal-fetal interface as the final pathological assault in recurrent spo...
Picomolar gradients of progesterone select functional human sperm even in subfertile samples [0.03%]
皮摩尔浓度的孕酮梯度能甚至从生育力不足的样本中筛选出功能正常的人类精子
L V Gatica,H A Guidobaldi,M M Montesinos et al.
L V Gatica et al.
More than 1 million infertility treatments are practiced around the world per year, but only 30% of the couples succeed in taking a baby home. Reproductive technology depends in part on sperm quality, which influences not only fertilization...
Genetic association studies in female reproduction: from candidate-gene approaches to genome-wide mapping [0.03%]
女性生殖的遗传关联研究：从候选基因方法到全基因组映射
Han Zhao,Zi-Jiang Chen
Han Zhao
Many genetic association studies have been performed to investigate disorders of female reproduction, such as polycystic ovary syndrome, premature ovarian failure and endometriosis. These disorders typically manifest heterogeneously, and th...
New insights on the origin and relevance of aneuploidy in human spermatozoa [0.03%]
人类精子染色体非整倍体的发生和意义的新见解
C Templado,L Uroz,A Estop
C Templado
In humans, the most common chromosomal abnormality is aneuploidy. Because the majority of aneuploid conceptuses die during the early stages of embryonic development, an accurate estimate of the frequency of aneuploidy at conception can only...
G Chittoor,V S Farook,S Puppala et al.
G Chittoor et al.
Preterm birth (PTB) is a complex trait, but little is known regarding its major genetic determinants. The objective of this study is to localize genes that influence susceptibility to PTB in Mexican Americans (MAs), a minority population in...
Estrogen promotes the growth of decidual stromal cells in human early pregnancy [0.03%]
雌激素通过促进蜕膜细胞增殖促进早期妊娠生长
Jun Shao,Ming-Qing Li,Yu-Han Meng et al.
Jun Shao et al.
Interleukin-24 (IL-24) is a novel tumor suppressor gene, which has suppressor activity in a broad spectrum of human cancer cells. The present study aimed to elucidate the biological function of IL-24 and its receptors (IL-20R1, IL-20R2 and ...
Functional human sperm capacitation requires both bicarbonate-dependent PKA activation and down-regulation of Ser/Thr phosphatases by Src family kinases [0.03%]
人精子获能需要碳酸氢根依赖的蛋白激酶A活化以及Src家族激酶介导的丝氨酸/苏氨酸磷酸酶活性下降
M A Battistone,V G Da Ros,A M Salicioni et al.
M A Battistone et al.
In all mammalian species studied so far, sperm capacitation correlates with an increase in protein tyrosine (Tyr) phosphorylation mediated by a bicarbonate-dependent cAMP/protein kinase A (PKA) pathway. Recent studies in mice revealed, howe...