R John Aitken,Brett Nixon
R John Aitken
Capacitation is a remarkable process whereby spermatozoa prepare themselves for engagement with the oocyte. Although the existence of this process has been appreciated as a biological phenomenon for more than half a century, its molecular u...
TGFβ1 and SGK1-sensitive store-operated Ca2+ entry and Orai1 expression in endometrial Ishikawa cells [0.03%]
TGFβ1和SGK1敏感的内膜ISHIKAWA细胞_STORE OPERATED钙 ENTRY及Orai1表达
S Schmidt,S Schneider,W Yang et al.
S Schmidt et al.
The serum-and-glucocorticoid-inducible-kinase-1 (SGK1) is ubiquitously expressed and under genomic control by cell stress, hormones and further mediators. A most powerful stimulator of SGK1 expression is transforming growth factor TGFβ1. S...
Expression and function of cyclooxygenase-2 is necessary for hamster blastocyst hatching [0.03%]
环氧合酶-2在 Syrian仓鼠囊胚孵化中的表达和功能研究
Shubhendu Sen Roy,Polani B Seshagiri
Shubhendu Sen Roy
Blastocyst hatching is critical for successful implantation leading to pregnancy. Its failure causes infertility. The phenomenon of blastocyst hatching in humans is poorly understood and the available information on this stems from studies ...
The role of glycans in immune evasion: the human fetoembryonic defence system hypothesis revisited [0.03%]
糖链的免疫逃逸作用：人类胎儿胚胎防御系统的假设再探
Gary F Clark
Gary F Clark
Emerging data suggest that mechanisms to evade the human immune system may be shared by the conceptus, tumour cells, persistent pathogens and viruses. It is therefore timely to revisit the human fetoembryonic defense system (Hu-FEDS) hypoth...
M Lebbe,T K Woodruff
M Lebbe
In women, ovary and adrenal gland produce androgens. Androgens are essential drivers of the primordial to antral follicle development, prior to serving as substrate for estrogen production in the later stages of folliculogenesis. Androgens ...
Impact of oxygen concentration on adult murine pre-antral follicle development in vitro and the corresponding metabolic profile [0.03%]
氧浓度对成年小鼠窦前卵泡体外发育的影响及其相应的代谢轮廓
Debra A Gook,D H Edgar,K Lewis et al.
Debra A Gook et al.
Oxygen concentration during in vitro culture has a significant effect on the physiology of embryos, altering metabolic profile and developmental outcome. Although atmospheric oxygen has been used routinely for the culture of ovarian follicl...
Human embryonic poly(A)-binding protein (EPAB) alternative splicing is differentially regulated in human oocytes and embryos [0.03%]
人类卵母细胞和胚胎中的人类胚胎多聚腺苷酸结合蛋白（EPAB）可变剪接的调节不同
Ozlem Guzeloglu-Kayisli,Maria D Lalioti,Elnur Babayev et al.
Ozlem Guzeloglu-Kayisli et al.
Oocyte maturation is associated with suppression of transcriptional activity. Consequently, gene expression during oocyte maturation, fertilization and early embryo development, until zygotic genome activation (ZGA) is primarily regulated b...
Uterine natural killer cells pace early development of mouse decidua basalis [0.03%]
子宫自然杀伤细胞调控小鼠基蜕膜的早期发育事件
A P Hofmann,S A Gerber,B A Croy
A P Hofmann
Pregnancy involves progressive relationship changes between conceptus-derived trophoblasts and maternal decidual vessels and leukocytes. Uterine natural killer (uNK) cells, the dominant leukocytes in early human and mouse decidua, have late...
G W Montgomery,K T Zondervan,D R Nyholt
G W Montgomery
Genetic factors contribute to risk of many common diseases affecting reproduction and fertility. In recent years, methods for genome-wide association studies (GWAS) have revolutionized gene discovery for common traits and diseases. Results ...
Activation of the aryl hydrocarbon receptor by a component of cigarette smoke reduces germ cell proliferation in the human fetal ovary [0.03%]
烟雾成分激活芳烃受体抑制人胎卵巢生殖细胞增殖
Richard A Anderson,Luke McIlwain,Shiona Coutts et al.
Richard A Anderson et al.
Fetal life is a critical time for female fertility, when germ cells complete proliferation, initiate meiosis and ultimately form the lifetime stock of primordial follicles. Female fertility may be reduced by in utero exposure to cigarette s...