Species-specific differences in follicular antral sizes result from diffusion-based limitations on the thickness of the granulosa cell layer [0.03%]
卵泡腔大小的种属差异由颗粒细胞层厚度的扩散限制引起
M Bächler,D Menshykau,Ch De Geyter et al.
M Bächler et al.
The size of mature oocytes is similar across mammalian species, yet the size of ovarian follicles increases with species size, with some ovarian follicles reaching diameters>1000-fold the size of the enclosed oocyte. Here we show that the d...
Gain of 20q11.21 in human embryonic stem cells improves cell survival by increased expression of Bcl-xL [0.03%]
人类胚胎干细胞通过Bcl-xL表达增强获得20q11.21可提高细胞存活率
H T Nguyen,M Geens,A Mertzanidou et al.
H T Nguyen et al.
Gain of 20q11.21 is a chromosomal abnormality that is recurrently found in human pluripotent stem cells and cancers, strongly suggesting that this mutation confers a proliferative or survival advantage to these cells. In this work we studie...
Mesenchymal origin of multipotent human testis-derived stem cells in human testicular cell cultures [0.03%]
人类睾丸细胞培养中多能干细胞的间充质起源
J V Chikhovskaya,S K M van Daalen,C M Korver et al.
J V Chikhovskaya et al.
In contrast to mouse germ cell-derived pluripotent stem cells, the pluripotent state of human testis-derived embryonic stem cell (ESC)-like that spontaneously arise in primary testicular cell cultures remains controversial. Recent studies h...
Christopher L R Barratt
Christopher L R Barratt
MHR welcomes high-quality basic reproductive research around pregnancy [0.03%]
《生理学报告》欢迎高质量的生殖生物学相关原创研究论文投稿
J E Norman,S Tong
J E Norman
Morphological and cytogenetic assessment of cleavage and blastocyst stage embryos [0.03%]
分裂期和囊胚期胚胎的形态及细胞遗传学评估
E Fragouli,S Alfarawati,K Spath et al.
E Fragouli et al.
Morphological assessments are the main way in which fertility clinics select in vitro generated embryo(s) for transfer to the uterus. However, it is widely acknowledged that the microscopic appearance of an embryo is only weakly correlated ...
Pathogenic variants screening in five non-obstructive azoospermia-associated genes [0.03%]
五种无梗阻性无精子症相关基因致病突变的筛查研究
Chuncheng Lu,Miaofei Xu,Rong Wang et al.
Chuncheng Lu et al.
Non-obstructive azoospermia (NOA) is one of the most severe forms of male infertility and a recent, genome-wide association study (GWAS) has identified four risk loci associated with NOA. However, a large portion of the heritability of NOA ...
Chimeras of sperm PLCζ reveal disparate protein domain functions in the generation of intracellular Ca2+ oscillations in mammalian eggs at fertilization [0.03%]
嵌合型精子磷脂酶Cζ揭示了其不同蛋白结构域在哺乳动物卵子受精时诱导胞内Ca2+振荡中的不同功能
Maria Theodoridou,Michail Nomikos,Dimitris Parthimos et al.
Maria Theodoridou et al.
Phospholipase C-zeta (PLCζ) is a sperm-specific protein believed to cause Ca(2+) oscillations and egg activation during mammalian fertilization. PLCζ is very similar to the somatic PLCδ1 isoform but is far more potent in mobilizing Ca(2+...
Comparative expression of thioredoxin-1 in uterine leiomyomas and myometrium [0.03%]
子宫平滑肌瘤和肌瘤周围子宫肌层中硫氧还蛋白-1的表达比较
Ping Hou,Lu Zhao,Ye Li et al.
Ping Hou et al.
Uterine leiomyomas are benign tumors that develop from smooth muscle cells (SMCs). The reactive oxygen species (ROS) have been shown to be involved in the signaling pathways that stimulate proliferation of a variety of cell types. Thioredox...
Comparative Study
Molecular human reproduction. 2014 Feb;20(2):148-54. DOI:10.1093/molehr/gat069 2014
Stephen G Hillier
Stephen G Hillier
Through pioneering human IVF as a global infertility treatment, Robert Edwards and his clinical partner Patrick Steptoe launched the field of IVF endocrinology. Following repeated failures with oocytes collected in human menopausal gonadotr...