The CD24hi smooth muscle subpopulation is the predominant fraction in uterine fibroids [0.03%]
CD24hi平滑肌亚群是子宫肌瘤的主要组分
Michael Drosch,Nicole Schmidt,Dominique Nadine Markowski et al.
Michael Drosch et al.
Uterine fibroids are the most common gynecological tumors affecting women in their reproductive age. Despite this high incidence the pathogenesis of fibroids is widely unsolved. Whereas formerly only imbalances in hormonal levels were consi...
Getting too sweet: galectin-1 dysregulation in gestational diabetes mellitus [0.03%]
妊娠糖尿病中半乳糖凝集素-1的失调
Sandra M Blois,Barbara Y Gueuvoghlanian-Silva,Irene Tirado-González et al.
Sandra M Blois et al.
Galectin-1 (gal-1) is a prototype carbohydrate-binding protein, whose dysregulation is associated with adverse pregnancy outcomes such as spontaneous abortion and pre-eclampsia. Furthermore, it is known that faulty gal-1 protein production ...
Activation of endocrine-related gene expression in placental choriocarcinoma cell lines following DNA methylation knock-down [0.03%]
DNA甲基化敲低后胎盘绒癌细胞系中内分泌相关基因表达的激活
K Hogg,W P Robinson,A G Beristain
K Hogg
Increasingly, placental DNA methylation is assessed as a factor in pregnancy-related complications, yet the transcriptional impact of such findings is not always clear. Using a proliferative in vitro placental model, the effect of DNA methy...
Statins prevent cervical remodeling, myometrial contractions and preterm labor through a mechanism that involves hemoxygenase-1 and complement inhibition [0.03%]
他汀类药物通过血红素氧合酶-1和补体抑制机制预防宫颈重塑，肌层收缩和早产
Juan M Gonzalez,Silvia M A Pedroni,Guillermina Girardi
Juan M Gonzalez
Preterm birth (PTB) is a major public health problem, with a global prevalence of 9.6% and over a million annual neonatal deaths. In a mouse model of preterm labor (PTL) induced by intravaginal administration of a subclinical dose of lipopo...
The human testis-specific proteome defined by transcriptomics and antibody-based profiling [0.03%]
基于转录组学和抗体的人类睾丸特异性蛋白质组定義
D Djureinovic,L Fagerberg,B Hallström et al.
D Djureinovic et al.
The testis' function is to produce haploid germ cells necessary for reproduction. Here we have combined a genome-wide transcriptomics analysis with immunohistochemistry-based protein profiling to characterize the molecular components of the...
Hypoxia inducible factor 2α/insulin-like growth factor receptor signal loop supports the proliferation and Oct-4 maintenance of mouse germline stem cells [0.03%]
缺氧诱导因子2α/胰岛素样生长因子受体信号环支持小鼠生殖细胞干细胞的增殖和Oct-4维持
Y-H Huang,M-H Lin,P-C Wang et al.
Y-H Huang et al.
Hypoxia inducible factor 2α (HIF-2α) is critical for primordial germ cell (PGC) survival as knockout of HIF-2α (HIF-2α(-/-)) decreases both expression of Oct-4 and PGC number in genital ridge. Hypoxia is known to stabilize HIF-2α prote...
A Van Langendonckt,L Romeu,J Ambroise et al.
A Van Langendonckt et al.
Cryobanking and transplantation of ovarian tissue is a promising approach to restore fertility in cancer patients. However, ischemic stress following avascular ovarian cortex grafting is known to induce stromal tissue fibrosis and alteratio...
SHCBP1L, a conserved protein in mammals, is predominantly expressed in male germ cells and maintains spindle stability during meiosis in testis [0.03%]
SHCBP1L是哺乳动物中保守的蛋白质，在雄性生殖细胞中高表达并维持其在睾丸减数分裂过程中纺锤体稳定性
Mingxi Liu,Xiaodan Shi,Ye Bi et al.
Mingxi Liu et al.
Male subfertility due to falling sperm counts has become an increasing problem over a short timescale (50-70 years). Recently, bioinformatics analysis of the human testis proteome has revealed the existence of human-testicular-predominantly...
Amphiregulin co-operates with bone morphogenetic protein 15 to increase bovine oocyte developmental competence: effects on gap junction-mediated metabolite supply [0.03%]
氨黑素增加牛卵母细胞发育潜能与骨形素15协同作用：对缝隙连接介导的代谢物供应的影响
Satoshi Sugimura,Lesley J Ritter,Melanie L Sutton-McDowall et al.
Satoshi Sugimura et al.
This study assessed the participation of amphiregulin (AREG) and bone morphogenetic protein 15 (BMP15) during maturation of bovine cumulus-oocyte complexes (COCs) on cumulus cell function and their impact on subsequent embryo development. A...